| Literature DB >> 25092309 |
Jeanine Ward1, Chitra Kanchagar2, Isana Veksler-Lublinsky2, Rosalind C Lee2, Mitchell R McGill3, Hartmut Jaeschke3, Steven C Curry4, Victor R Ambros5.
Abstract
We have identified, by quantitative real-time PCR, hundreds of miRNAs that are dramatically elevated in the plasma or serum of acetaminophen (APAP) overdose patients. Most of these circulating microRNAs decrease toward normal levels during treatment with N-acetyl cysteine (NAC). We identified a set of 11 miRNAs whose profiles and dynamics in the circulation during NAC treatment can discriminate APAP hepatotoxicity from ischemic hepatitis. The elevation of certain miRNAs can precede the dramatic rise in the standard biomarker, alanine aminotransferase (ALT), and these miRNAs also respond more rapidly than ALT to successful treatment. Our results suggest that miRNAs can serve as sensitive diagnostic and prognostic clinical tools for severe liver injury and could be useful for monitoring drug-induced liver injury during drug discovery.Entities:
Keywords: hsa-miR-122-5p; hsa-miR-3646-3p; hsa-miR-412
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Year: 2014 PMID： 25092309 PMCID： PMC4143020 DOI： 10.1073/pnas.1412608111
Source DB: PubMed Journal: Proc Natl Acad Sci U S A ISSN： 0027-8424 Impact factor: 11.205