Literature DB >> 28633863

Targeted Deletion of an Entire Chromosome Using CRISPR/Cas9.

Fatwa Adikusuma1, Nicole Williams2, Frank Grutzner3, James Hughes2, Paul Thomas4.   

Abstract

CRISPR/Cas9 genome editing can facilitate efficient deletion of genomic region, but it has not been used to delete an entire chromosome. Here, Adikusuma et al. show proof-of-concept for efficient CRISPR-mediated selective chromosome deletion by removing the centromere or shredding the chromosome arm in mouse embryonic stem cells and zygotes.
Copyright © 2017 The American Society of Gene and Cell Therapy. Published by Elsevier Inc. All rights reserved.

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Year:  2017        PMID： 28633863      PMCID： PMC5542798          DOI： 10.1016/j.ymthe.2017.05.021

Source DB:  PubMed          Journal:  Mol Ther        ISSN： 1525-0016            Impact factor:   11.454


  10 in total

1.  The phenotype of 45,X/46,XY mosaicism: an analysis of 92 prenatally diagnosed cases.

Authors:  H J Chang; R D Clark; H Bachman
Journal:  Am J Hum Genet       Date:  1990-01       Impact factor: 11.025

2.  Applications of CRISPR technologies in research and beyond.

Authors:  Rodolphe Barrangou; Jennifer A Doudna
Journal:  Nat Biotechnol       Date:  2016-09-08       Impact factor: 54.908

3.  Genome engineering using the CRISPR-Cas9 system.

Authors:  F Ann Ran; Patrick D Hsu; Jason Wright; Vineeta Agarwala; David A Scott; Feng Zhang
Journal:  Nat Protoc       Date:  2013-10-24       Impact factor: 13.491

Review 4.  Cas9 as a versatile tool for engineering biology.

Authors:  Prashant Mali; Kevin M Esvelt; George M Church
Journal:  Nat Methods       Date:  2013-10       Impact factor: 28.547

5.  Mutagenesis. Smoking is associated with mosaic loss of chromosome Y.

Authors:  Jan P Dumanski; Chiara Rasi; Mikael Lönn; Hanna Davies; Martin Ingelsson; Vilmantas Giedraitis; Lars Lannfelt; Patrik K E Magnusson; Cecilia M Lindgren; Andrew P Morris; David Cesarini; Magnus Johannesson; Eva Tiensuu Janson; Lars Lind; Nancy L Pedersen; Erik Ingelsson; Lars A Forsberg
Journal:  Science       Date:  2014-12-04       Impact factor: 47.728

Review 6.  Functions of the centromere and kinetochore in chromosome segregation.

Authors:  Frederick G Westhorpe; Aaron F Straight
Journal:  Curr Opin Cell Biol       Date:  2013-03-13       Impact factor: 8.382

7.  Generating genetically modified mice using CRISPR/Cas-mediated genome engineering.

Authors:  Hui Yang; Haoyi Wang; Rudolf Jaenisch
Journal:  Nat Protoc       Date:  2014-07-24       Impact factor: 13.491

8.  Genotype, phenotype, and karyotype correlation in the XO mouse model of Turner Syndrome.

Authors:  Frank J Probst; Mitchell Lance Cooper; Sau Wai Cheung; Monica J Justice
Journal:  J Hered       Date:  2008-05-21       Impact factor: 2.645

9.  CCTop: An Intuitive, Flexible and Reliable CRISPR/Cas9 Target Prediction Tool.

Authors:  Manuel Stemmer; Thomas Thumberger; Maria Del Sol Keyer; Joachim Wittbrodt; Juan L Mateo
Journal:  PLoS One       Date:  2015-04-24       Impact factor: 3.240

10.  Multiplex genome engineering in human cells using all-in-one CRISPR/Cas9 vector system.

Authors:  Tetsushi Sakuma; Ayami Nishikawa; Satoshi Kume; Kazuaki Chayama; Takashi Yamamoto
Journal:  Sci Rep       Date:  2014-06-23       Impact factor: 4.379
  10 in total
  25 in total

1.  Generation of Sex-Reversed Female Clonal Mice via CRISPR-Cas9-Mediated Y Chromosome Deletion in Male Embryonic Stem Cells.

Authors:  Yiren Qin; Bokey Wong; Liangwen Zhong; Fuqiang Geng; Luis F Parada; Duancheng Wen
Journal:  CRISPR J       Date:  2021-02-09

2.  Rodent gene drives for conservation: opportunities and data needs.

Authors:  John Godwin; Megan Serr; S Kathleen Barnhill-Dilling; Dimitri V Blondel; Peter R Brown; Karl Campbell; Jason Delborne; Alun L Lloyd; Kevin P Oh; Thomas A A Prowse; Royden Saah; Paul Thomas
Journal:  Proc Biol Sci       Date:  2019-11-06       Impact factor: 5.349

Review 3.  Mosaic loss of human Y chromosome: what, how and why.

Authors:  Xihan Guo; Xueqin Dai; Tao Zhou; Han Wang; Juan Ni; Jinglun Xue; Xu Wang
Journal:  Hum Genet       Date:  2020-02-04       Impact factor: 4.132

4.  Generation of sex-reversed female clonal mice via CRISPR/Cas9-mediated Y chromosome deletion in male embryonic stem cells.

Authors:  Yiren Qin; Fuqiang Geng; Duancheng Wen
Journal:  Methods Cell Biol       Date:  2022-04-09       Impact factor: 1.829

Review 5.  DOCKopathies: A systematic review of the clinical pathologies associated with human DOCK pathogenic variants.

Authors:  Adrienne Samani; Katherine G English; Michael A Lopez; Camille L Birch; Donna M Brown; Gurpreet Kaur; Elizabeth A Worthey; Matthew S Alexander
Journal:  Hum Mutat       Date:  2022-05-20       Impact factor: 4.700

Review 6.  Neurodevelopmental copy-number variants: A roadmap to improving outcomes by uniting patient advocates, researchers, and clinicians for collective impact.

Authors: 
Journal:  Am J Hum Genet       Date:  2022-08-04       Impact factor: 11.043

Review 7.  Celebrating Mendel, McClintock, and Darlington: On end-to-end chromosome fusions and nested chromosome fusions.

Authors:  Martin A Lysak
Journal:  Plant Cell       Date:  2022-07-04       Impact factor: 12.085

Review 8.  CRISPR-based genome editing through the lens of DNA repair.

Authors:  Tarun S Nambiar; Lou Baudrier; Pierre Billon; Alberto Ciccia
Journal:  Mol Cell       Date:  2022-01-20       Impact factor: 17.970

Review 9.  The diverse consequences of aneuploidy.

Authors:  Narendra Kumar Chunduri; Zuzana Storchová
Journal:  Nat Cell Biol       Date:  2019-01-02       Impact factor: 28.824

10.  Efficient TALEN-mediated gene knockin at the bovine Y chromosome and generation of a sex-reversal bovine.

Authors:  Ming Wang; ZhaoLin Sun; Fangrong Ding; Haiping Wang; Ling Li; Xue Li; Xianjin Zheng; Ning Li; Yunping Dai; Changxin Wu
Journal:  Cell Mol Life Sci       Date:  2021-05-28       Impact factor: 9.261
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