Lyvia Biagi1,2, Arthur Hirata Bertachi1,2, Ignacio Conget3, Carmen Quirós3, Marga Giménez3, F Javier Ampudia-Blasco4, Paolo Rossetti5, Jorge Bondia6, Josep Vehí1. 1. 1 Institut d'Informàtica i Aplicacions, Universitat de Girona, Girona, Spain. 2. 2 Federal University of Technology-Paraná (UTFPR), Guarapuava, Brazil. 3. 3 Diabetes Unit, Endocrinology and Nutrition Department, Hospital Clínic i Universitari, Barcelona, Spain. 4. 4 Endocrinology and Nutrition Department, Hospital Clínico Universitario de València, Spain. 5. 5 Hospital Francesc de Borja de Gandia, València, Spain. 6. 6 Instituto Universitario de Automática e Informática Industrial, Universitat Politècnica de València, València, Spain.
Abstract
BACKGROUND: Closed-loop (CL) systems aims to outperform usual treatments in blood glucose control and continuous glucose monitors (CGM) are a key component in such systems. Meals represents one of the main disturbances in blood glucose control, and postprandial period (PP) is a challenging situation for both CL system and CGM accuracy. METHODS: We performed an extensive analysis of sensor's performance by numerical accuracy and precision during PP, as well as its influence in blood glucose control under CL therapy. RESULTS: During PP the mean absolute relative difference (MARD) for both sensors presented lower accuracy in the hypoglycemic range (19.4 ± 12.8%) than in other ranges (12.2 ± 8.6% in euglycemic range and 9.3 ± 9.3% in hyperglycemic range). The overall MARD was 12.1 ± 8.2%. We have also observed lower MARD for rates of change between 0 and 2 mg/dl. In CL therapy, the 10 trials with the best sensor spent less time in hypoglycemia (PG < 70 mg/dl) than the 10 trials with the worst sensors (2 ± 7 minutes vs 32 ± 38 minutes, respectively). CONCLUSIONS: In terms of accuracy, our results resemble to previously reported. Furthermore, our results showed that sensors with the lowest MARD spent less time in hypoglycemic range, indicating that the performance of CL algorithm to control PP was related to sensor accuracy.
BACKGROUND: Closed-loop (CL) systems aims to outperform usual treatments in blood glucose control and continuous glucose monitors (CGM) are a key component in such systems. Meals represents one of the main disturbances in blood glucose control, and postprandial period (PP) is a challenging situation for both CL system and CGM accuracy. METHODS: We performed an extensive analysis of sensor's performance by numerical accuracy and precision during PP, as well as its influence in blood glucose control under CL therapy. RESULTS: During PP the mean absolute relative difference (MARD) for both sensors presented lower accuracy in the hypoglycemic range (19.4 ± 12.8%) than in other ranges (12.2 ± 8.6% in euglycemic range and 9.3 ± 9.3% in hyperglycemic range). The overall MARD was 12.1 ± 8.2%. We have also observed lower MARD for rates of change between 0 and 2 mg/dl. In CL therapy, the 10 trials with the best sensor spent less time in hypoglycemia (PG < 70 mg/dl) than the 10 trials with the worst sensors (2 ± 7 minutes vs 32 ± 38 minutes, respectively). CONCLUSIONS: In terms of accuracy, our results resemble to previously reported. Furthermore, our results showed that sensors with the lowest MARD spent less time in hypoglycemic range, indicating that the performance of CL algorithm to control PP was related to sensor accuracy.
Authors: Arianne C Van Bon; Lisanne D Jonker; Rob Koebrugge; Robin Koops; Joost B L Hoekstra; J Hans DeVries Journal: J Diabetes Sci Technol Date: 2012-09-01
Authors: J Kropff; D Bruttomesso; W Doll; A Farret; S Galasso; Y M Luijf; J K Mader; J Place; F Boscari; T R Pieber; E Renard; J H DeVries Journal: Diabetes Obes Metab Date: 2014-09-10 Impact factor: 6.577