Jeroen Hoogland1, Judith A Boel1,2, Rob M A de Bie1, Ronald B Geskus3, Ben A Schmand2,4, John C Dalrymple-Alford5, Connie Marras6, Charles H Adler7, Jennifer G Goldman8, Alexander I Tröster9, David J Burn10, Irene Litvan11, Gert J Geurtsen4. 1. Department of Neurology, Academic Medical Center Amsterdam, Amsterdam, The Netherlands. 2. Department of Psychology, University of Amsterdam, Amsterdam, The Netherlands. 3. Department of Clinical Epidemiology, Biostatistics and Bioinformatics, Academic Medical Center Amsterdam, Amsterdam, The Netherlands. 4. Department of Medical Psychology, Academic Medical Center Amsterdam, Amsterdam, The Netherlands. 5. New Zealand Brain Research Institute, Brain Research New Zealand, Centre of Research Excellence, Christchurch, New Zealand. 6. Morton and Gloria Shulman Movement Disorders Centre and the Edmond J. Safra Program in Parkinson's Disease, Toronto Western Hospital, University of Toronto, Toronto, Ontario, Canada. 7. Arizona Parkinson's Disease Consortium, Mayo Clinic Arizona, Scottsdale, Arizona, USA, and Banner Sun Health Research Institute, Sun City, Arizona, USA. 8. Department of Neurological Sciences, Section of Parkinson Disease and Movement Disorders, Rush University Medical Center, Chicago, Illinois, USA. 9. Department of Clinical Neuropsychology and Center for Neuromodulation, Barrow Neurological Institute, Phoenix, Arizona, USA. 10. Institute of Neuroscience, Newcastle University, Newcastle upon Tyne, United Kingdom. 11. Department of Neurosciences University of California San Diego, Movement Disorder Center, San Diego, California, USA.
Abstract
BACKGROUND: The International Parkinson and Movement Disorder Society criteria for mild cognitive impairment in PD were recently formulated. OBJECTIVES: The aim of this international study was to evaluate the predictive validity of the comprehensive (level II) version of these criteria by assessment of their contribution to the hazard of PD dementia. METHODS: Individual patient data were selected from four separate studies on cognition in PD that provided information on demographics, motor examination, depression, neuropsychological examination suitable for application of level II criteria, and longitudinal follow-up for conversion to dementia. Survival analysis evaluated the predictive value of level II criteria for cognitive decline toward dementia as expressed by the relative hazard of dementia. RESULTS: A total of 467 patients were included. The analyses showed a clear contribution of impairment according to level II mild cognitive impairment criteria, age, and severity of PD motor symptoms to the hazard of dementia. There was a trend of increasing hazard of dementia with declining neuropsychological performance. CONCLUSIONS: This is the first large international study evaluating the predictive validity of level II mild cognitive impairment criteria for PD. The results showed a clear and unique contribution of classification according to level II criteria to the hazard of PD dementia. This finding supports their predictive validity and shows that they contribute important new information on the hazard of dementia, beyond known demographic and PD-specific factors of influence.
BACKGROUND: The International Parkinson and Movement Disorder Society criteria for mild cognitive impairment in PD were recently formulated. OBJECTIVES: The aim of this international study was to evaluate the predictive validity of the comprehensive (level II) version of these criteria by assessment of their contribution to the hazard of PD dementia. METHODS: Individual patient data were selected from four separate studies on cognition in PD that provided information on demographics, motor examination, depression, neuropsychological examination suitable for application of level II criteria, and longitudinal follow-up for conversion to dementia. Survival analysis evaluated the predictive value of level II criteria for cognitive decline toward dementia as expressed by the relative hazard of dementia. RESULTS: A total of 467 patients were included. The analyses showed a clear contribution of impairment according to level II mild cognitive impairment criteria, age, and severity of PD motor symptoms to the hazard of dementia. There was a trend of increasing hazard of dementia with declining neuropsychological performance. CONCLUSIONS: This is the first large international study evaluating the predictive validity of level II mild cognitive impairment criteria for PD. The results showed a clear and unique contribution of classification according to level II criteria to the hazard of PD dementia. This finding supports their predictive validity and shows that they contribute important new information on the hazard of dementia, beyond known demographic and PD-specific factors of influence.
Authors: Jeroen Hoogland; Lennard L van Wanrooij; Judith A Boel; Jennifer G Goldman; Glenn T Stebbins; John C Dalrymple-Alford; Connie Marras; Charles H Adler; Carme Junque; Kenn F Pedersen; Brit Mollenhauer; Cyrus P Zabetian; Paul J Eslinger; Simon J G Lewis; Ruey-Meei Wu; Martin Klein; Maria C Rodriguez-Oroz; Davide M Cammisuli; Paolo Barone; Roberta Biundo; Rob M A de Bie; Ben A Schmand; Alexander I Tröster; David J Burn; Irene Litvan; J Vincent Filoteo; Gert J Geurtsen; Daniel Weintraub Journal: Mov Disord Date: 2018-09-14 Impact factor: 10.338
Authors: J A Obeso; M Stamelou; C G Goetz; W Poewe; A E Lang; D Weintraub; D Burn; G M Halliday; E Bezard; S Przedborski; S Lehericy; D J Brooks; J C Rothwell; M Hallett; M R DeLong; C Marras; C M Tanner; G W Ross; J W Langston; C Klein; V Bonifati; J Jankovic; A M Lozano; G Deuschl; H Bergman; E Tolosa; M Rodriguez-Violante; S Fahn; R B Postuma; D Berg; K Marek; D G Standaert; D J Surmeier; C W Olanow; J H Kordower; P Calabresi; A H V Schapira; A J Stoessl Journal: Mov Disord Date: 2017-09 Impact factor: 10.338
Authors: Dag Aarsland; Lucia Batzu; Glenda M Halliday; Gert J Geurtsen; Clive Ballard; K Ray Chaudhuri; Daniel Weintraub Journal: Nat Rev Dis Primers Date: 2021-07-01 Impact factor: 52.329
Authors: Kyla-Louise Horne; Michael R MacAskill; Daniel J Myall; Leslie Livingston; Sophie Grenfell; Maddie J Pascoe; Bob Young; Reza Shoorangiz; Tracy R Melzer; Toni L Pitcher; Tim J Anderson; John C Dalrymple-Alford Journal: Mov Disord Clin Pract Date: 2021-02-18