| Literature DB >> 28887905 |
J A Obeso1,2,3, M Stamelou4,5, C G Goetz6, W Poewe7, A E Lang8,9, D Weintraub10,11, D Burn12, G M Halliday13,14, E Bezard15,16, S Przedborski17,18, S Lehericy19,20, D J Brooks21,22, J C Rothwell23, M Hallett24, M R DeLong25, C Marras26, C M Tanner27,28, G W Ross29, J W Langston30, C Klein31, V Bonifati32, J Jankovic33, A M Lozano34, G Deuschl35, H Bergman36,37,38, E Tolosa39,40, M Rodriguez-Violante41,42, S Fahn43, R B Postuma44, D Berg45, K Marek46, D G Standaert47, D J Surmeier48, C W Olanow49, J H Kordower50,51, P Calabresi52,53, A H V Schapira54, A J Stoessl55,56.
Abstract
This article reviews and summarizes 200 years of Parkinson's disease. It comprises a relevant history of Dr. James Parkinson's himself and what he described accurately and what he missed from today's perspective. Parkinson's disease today is understood as a multietiological condition with uncertain etiopathogenesis. Many advances have occurred regarding pathophysiology and symptomatic treatments, but critically important issues are still pending resolution. Among the latter, the need to modify disease progression is undoubtedly a priority. In sum, this multiple-author article, prepared to commemorate the bicentenary of the shaking palsy, provides a historical state-of-the-art account of what has been achieved, the current situation, and how to progress toward resolving Parkinson's disease.Entities:
Keywords: 200 years anniversary; Parkinson's disease; Shaking Palsy
Mesh：
Year: 2017 PMID： 28887905 PMCID： PMC5685546 DOI： 10.1002/mds.27115
Source DB: PubMed Journal: Mov Disord ISSN： 0885-3185 Impact factor: 10.338