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Literature DB >> 28592486

Exploring cancer metabolism using stable isotope-resolved metabolomics (SIRM).

Ronald C Bruntz^1,2, Andrew N Lane^3,2, Richard M Higashi^1,2, Teresa W-M Fan^4,2.

Abstract

Metabolic reprogramming is a hallmark of cancer. The changes in metabolism are adaptive to permit proliferation, survival, and eventually metastasis in a harsh environment. Stable isotope-resolved metabolomics (SIRM) is an approach that uses advanced approaches of NMR and mass spectrometry to analyze the fate of individual atoms from stable isotope-enriched precursors to products to deduce metabolic pathways and networks. The approach can be applied to a wide range of biological systems, including human subjects. This review focuses on the applications of SIRM to cancer metabolism and its use in understanding drug actions.

Entities: Disease Species

Keywords: cancer; isotopic tracer; mass spectrometry (MS); metabolism; metabolomics; nuclear magnetic resonance (NMR)

Mesh：

Substances：

Year: 2017 PMID： 28592486 PMCID： PMC5512057 DOI： 10.1074/jbc.R117.776054

Source DB: PubMed Journal: J Biol Chem ISSN： 0021-9258 Impact factor: 5.157

96 in total

1. On respiratory impairment in cancer cells.

Authors: O WARBURG
Journal: Science Date: 1956-08-10 Impact factor: 47.728

Review 2. Applications of NMR spectroscopy to systems biochemistry.

Authors: Teresa W-M Fan; Andrew N Lane
Journal: Prog Nucl Magn Reson Spectrosc Date: 2016-02-06 Impact factor: 9.795

Review 3. Progress and promise of FDG-PET imaging for cancer patient management and oncologic drug development.

Authors: Gary J Kelloff; John M Hoffman; Bruce Johnson; Howard I Scher; Barry A Siegel; Edward Y Cheng; Bruce D Cheson; Joyce O'shaughnessy; Kathryn Z Guyton; David A Mankoff; Lalitha Shankar; Steven M Larson; Caroline C Sigman; Richard L Schilsky; Daniel C Sullivan
Journal: Clin Cancer Res Date: 2005-04-15 Impact factor: 12.531

4. The use of stable isotope-labeled glycerol and oleic acid to differentiate the hepatic functions of DGAT1 and -2.

Authors: Jenson Qi; Wensheng Lang; John G Geisler; Ping Wang; Ioanna Petrounia; Selyna Mai; Charles Smith; Hossein Askari; Geoffrey T Struble; Robyn Williams; Sanjay Bhanot; Brett P Monia; Shariff Bayoumy; Eugene Grant; Gary W Caldwell; Matthew J Todd; Yin Liang; Micheal D Gaul; Keith T Demarest; Margery A Connelly
Journal: J Lipid Res Date: 2012-04-03 Impact factor: 5.922

5. The metabolic profile of tumors depends on both the responsible genetic lesion and tissue type.

Authors: Mariia O Yuneva; Teresa W M Fan; Thaddeus D Allen; Richard M Higashi; Dana V Ferraris; Takashi Tsukamoto; José M Matés; Francisco J Alonso; Chunmei Wang; Youngho Seo; Xin Chen; J Michael Bishop
Journal: Cell Metab Date: 2012-02-08 Impact factor: 27.287

6. Stable isotope-resolved metabolomic analysis of lithium effects on glial-neuronal metabolism and interactions.

Authors: Teresa W-M Fan; Peixiong Yuan; Andrew N Lane; Richard M Higashi; Yun Wang; Anahita B Hamidi; Rulun Zhou; Xavier Guitart; Guang Chen; Husseini K Manji; Rima Kaddurah-Daouk
Journal: Metabolomics Date: 2010-06-01 Impact factor: 4.290

7. MYC/PGC-1α Balance Determines the Metabolic Phenotype and Plasticity of Pancreatic Cancer Stem Cells.

Authors: Patricia Sancho; Emma Burgos-Ramos; Alejandra Tavera; Tony Bou Kheir; Petra Jagust; Matthieu Schoenhals; David Barneda; Katherine Sellers; Ramon Campos-Olivas; Osvaldo Graña; Catarina R Viera; Mariia Yuneva; Bruno Sainz; Christopher Heeschen
Journal: Cell Metab Date: 2015-09-10 Impact factor: 27.287

8. Proteomic analysis of pRb loss highlights a signature of decreased mitochondrial oxidative phosphorylation.

Authors: Brandon N Nicolay; Paul S Danielian; Filippos Kottakis; John D Lapek; Ioannis Sanidas; Wayne O Miles; Mantre Dehnad; Katrin Tschöp; Jessica J Gierut; Amity L Manning; Robert Morris; Kevin Haigis; Nabeel Bardeesy; Jacqueline A Lees; Wilhelm Haas; Nicholas J Dyson
Journal: Genes Dev Date: 2015-08-27 Impact factor: 11.361

9. Inhibition of acetyl-CoA carboxylase suppresses fatty acid synthesis and tumor growth of non-small-cell lung cancer in preclinical models.

Authors: Robert U Svensson; Seth J Parker; Lillian J Eichner; Matthew J Kolar; Martina Wallace; Sonja N Brun; Portia S Lombardo; Jeanine L Van Nostrand; Amanda Hutchins; Lilliana Vera; Laurie Gerken; Jeremy Greenwood; Sathesh Bhat; Geraldine Harriman; William F Westlin; H James Harwood; Alan Saghatelian; Rosana Kapeller; Christian M Metallo; Reuben J Shaw
Journal: Nat Med Date: 2016-09-19 Impact factor: 53.440

10. Glutamine synthetase activity fuels nucleotide biosynthesis and supports growth of glutamine-restricted glioblastoma.

Authors: Saverio Tardito; Anaïs Oudin; Shafiq U Ahmed; Fred Fack; Olivier Keunen; Liang Zheng; Hrvoje Miletic; Per Øystein Sakariassen; Adam Weinstock; Allon Wagner; Susan L Lindsay; Andreas K Hock; Susan C Barnett; Eytan Ruppin; Svein Harald Mørkve; Morten Lund-Johansen; Anthony J Chalmers; Rolf Bjerkvig; Simone P Niclou; Eyal Gottlieb
Journal: Nat Cell Biol Date: 2015-11-23 Impact factor: 28.824

39 in total

Review 1. Probing carbohydrate metabolism using hyperpolarized ¹³ C-labeled molecules.

Authors: Jaspal Singh; Eul Hyun Suh; Gaurav Sharma; Chalermchai Khemtong; A Dean Sherry; Zoltan Kovacs
Journal: NMR Biomed Date: 2018-11-26 Impact factor: 4.044

2. A unique model for SDH-deficient GIST: an endocrine-related cancer.

Authors: James F Powers; Brent Cochran; James D Baleja; Hadley D Sikes; Xue Zhang; Inna Lomakin; Troy Langford; Kassi Taylor Stein; Arthur S Tischler
Journal: Endocr Relat Cancer Date: 2018-07-02 Impact factor: 5.678

Review 3. Targeting Metabolic Cross Talk between Cancer Cells and Cancer-Associated Fibroblasts.

Authors: Jin G Jung; Anne Le
Journal: Adv Exp Med Biol Date: 2018 Impact factor: 2.622

4. A review of metabolism-associated biomarkers in lung cancer diagnosis and treatment.

Authors: Sanaya Bamji-Stocke; Victor van Berkel; Donald M Miller; Hermann B Frieboes
Journal: Metabolomics Date: 2018-06-01 Impact factor: 4.290

5. Stable Isotope-Resolved Metabolomics by NMR.

Authors: Penghui Lin; Andrew N Lane; Teresa W-M Fan
Journal: Methods Mol Biol Date: 2019

6. Tracer-Based Cancer Metabolomic Analysis.

Authors: Jianzhou Liu; Jing Huang; Gary Guishan Xiao
Journal: Adv Exp Med Biol Date: 2021 Impact factor: 2.622

7. Applications of Chromatography-Ultra High-Resolution MS for Stable Isotope-Resolved Metabolomics (SIRM) Reconstruction of Metabolic Networks.

Authors: Qiushi Sun; Teresa W-M Fan; Andrew N Lane; Richard M Higashi
Journal: Trends Analyt Chem Date: 2019-10-01 Impact factor: 12.296

Exploring cancer metabolism using stable isotope-resolved metabolomics (SIRM).

1. On respiratory impairment in cancer cells.

Review 2. Applications of NMR spectroscopy to systems biochemistry.

Review 3. Progress and promise of FDG-PET imaging for cancer patient management and oncologic drug development.

4. The use of stable isotope-labeled glycerol and oleic acid to differentiate the hepatic functions of DGAT1 and -2.

5. The metabolic profile of tumors depends on both the responsible genetic lesion and tissue type.

6. Stable isotope-resolved metabolomic analysis of lithium effects on glial-neuronal metabolism and interactions.

7. MYC/PGC-1α Balance Determines the Metabolic Phenotype and Plasticity of Pancreatic Cancer Stem Cells.

8. Proteomic analysis of pRb loss highlights a signature of decreased mitochondrial oxidative phosphorylation.

9. Inhibition of acetyl-CoA carboxylase suppresses fatty acid synthesis and tumor growth of non-small-cell lung cancer in preclinical models.

10. Glutamine synthetase activity fuels nucleotide biosynthesis and supports growth of glutamine-restricted glioblastoma.

Review 1. Probing carbohydrate metabolism using hyperpolarized ¹³ C-labeled molecules.

2. A unique model for SDH-deficient GIST: an endocrine-related cancer.

Review 3. Targeting Metabolic Cross Talk between Cancer Cells and Cancer-Associated Fibroblasts.

4. A review of metabolism-associated biomarkers in lung cancer diagnosis and treatment.

5. Stable Isotope-Resolved Metabolomics by NMR.

6. Tracer-Based Cancer Metabolomic Analysis.

7. Applications of Chromatography-Ultra High-Resolution MS for Stable Isotope-Resolved Metabolomics (SIRM) Reconstruction of Metabolic Networks.

Review 8. Novel methods in adrenal research: a metabolomics approach.

9. Targeting Metabolic Cross Talk Between Cancer Cells and Cancer-Associated Fibroblasts.

10. DNAJA1 Dysregulates Metabolism Promoting an Antiapoptotic Phenotype in Pancreatic Ductal Adenocarcinoma.

Review 2. Applications of NMR spectroscopy to systems biochemistry.

Review 3. Progress and promise of FDG-PET imaging for cancer patient management and oncologic drug development.

Review 1. Probing carbohydrate metabolism using hyperpolarized 13 C-labeled molecules.

Review 3. Targeting Metabolic Cross Talk between Cancer Cells and Cancer-Associated Fibroblasts.

Review 8. Novel methods in adrenal research: a metabolomics approach.

Review 1. Probing carbohydrate metabolism using hyperpolarized ¹³ C-labeled molecules.