Literature DB >> 28582513

Evidence of Ebola Virus Replication and High Concentration in Semen of a Patient During Recovery.

Kayla G Barnes1,2, Jason Kindrachuk3, Aaron E Lin1,2, Shirlee Wohl1,2, James Qu2, Samantha D Tostenson4, William R Dorman4, Michele Busby2, Katherine J Siddle1,2, Cynthia Y Luo1,2, Christian B Matranga1,2, Richard T Davey5, Pardis C Sabeti1,2, Daniel S Chertow3,5.   

Abstract

In one patient over time, we found that concentration of Ebola virus RNA in semen during recovery is remarkably higher than blood at peak illness. Virus in semen is replication-competent with no change in viral genome over time. Presence of sense RNA suggests replication in cells present in semen. Published by Oxford University Press for the Infectious Diseases Society of America 2017. This work is written by (a) US Government employee(s) and is in the public domain in the US.

Entities:  

Keywords:  Ebola; persistence; replication; semen; sexual transmission

Mesh：

Substances：

Year:  2017        PMID： 28582513      PMCID： PMC5850519          DOI： 10.1093/cid/cix518

Source DB:  PubMed          Journal:  Clin Infect Dis        ISSN： 1058-4838            Impact factor:   9.079


  13 in total

1.  Strand-specific real-time RT-PCR for distinguishing influenza vRNA, cRNA, and mRNA.

Authors:  Eiryo Kawakami; Tokiko Watanabe; Ken Fujii; Hideo Goto; Shinji Watanabe; Takeshi Noda; Yoshihiro Kawaoka
Journal:  J Virol Methods       Date:  2010-12-24       Impact factor: 2.014

Review 2.  The evolution of Ebola virus: Insights from the 2013-2016 epidemic.

Authors:  Edward C Holmes; Gytis Dudas; Andrew Rambaut; Kristian G Andersen
Journal:  Nature       Date:  2016-10-13       Impact factor: 49.962

3.  Molecular Evidence of Sexual Transmission of Ebola Virus.

Authors:  Suzanne E Mate; Jeffrey R Kugelman; Tolbert G Nyenswah; Jason T Ladner; Michael R Wiley; Thierry Cordier-Lassalle; Athalia Christie; Gary P Schroth; Stephen M Gross; Gloria J Davies-Wayne; Shivam A Shinde; Ratnesh Murugan; Sonpon B Sieh; Moses Badio; Lawrence Fakoli; Fahn Taweh; Emmie de Wit; Neeltje van Doremalen; Vincent J Munster; James Pettitt; Karla Prieto; Ben W Humrighouse; Ute Ströher; Joseph W DiClaro; Lisa E Hensley; Randal J Schoepp; David Safronetz; Joseph Fair; Jens H Kuhn; David J Blackley; A Scott Laney; Desmond E Williams; Terrence Lo; Alex Gasasira; Stuart T Nichol; Pierre Formenty; Francis N Kateh; Kevin M De Cock; Fatorma Bolay; Mariano Sanchez-Lockhart; Gustavo Palacios
Journal:  N Engl J Med       Date:  2015-10-14       Impact factor: 91.245

Review 4.  Tissue and cellular tropism, pathology and pathogenesis of Ebola and Marburg viruses.

Authors:  Roosecelis Brasil Martines; Dianna L Ng; Patricia W Greer; Pierre E Rollin; Sherif R Zaki
Journal:  J Pathol       Date:  2015-01       Impact factor: 7.996

5.  Severe Meningoencephalitis in a Case of Ebola Virus Disease: A Case Report.

Authors:  Daniel S Chertow; Avindra Nath; Anthony F Suffredini; Robert L Danner; Daniel S Reich; Rachel J Bishop; Richard W Childs; Andrew E Arai; Tara N Palmore; H Clifford Lane; Anthony S Fauci; Richard T Davey
Journal:  Ann Intern Med       Date:  2016-04-05       Impact factor: 25.391

6.  Ebola RNA Persistence in Semen of Ebola Virus Disease Survivors - Final Report.

Authors:  Gibrilla F Deen; Nathalie Broutet; Wenbo Xu; Barbara Knust; Foday R Sesay; Suzanna L R McDonald; Elizabeth Ervin; Jaclyn E Marrinan; Philippe Gaillard; Ndema Habib; Hongtu Liu; William Liu; Anna E Thorson; Francis Yamba; Thomas A Massaquoi; Faustin James; Archchun Ariyarajah; Christine Ross; Kyle Bernstein; Antoine Coursier; John Klena; Marylin Carino; Alie H Wurie; Yong Zhang; Marion S Dumbuya; Neetu Abad; Baimba Idriss; Teodora Wi; Sarah D Bennett; Tina Davies; Faiqa K Ebrahim; Elissa Meites; Dhamari Naidoo; Samuel J Smith; Patricia Ongpin; Tasneem Malik; Anshu Banerjee; Bobbie R Erickson; Yongjian Liu; Yang Liu; Ke Xu; Aaron Brault; Kara N Durski; Jörn Winter; Tara Sealy; Stuart T Nichol; Margaret Lamunu; James Bangura; Sihem Landoulsi; Amara Jambai; Oliver Morgan; Guizhen Wu; Mifang Liang; Qiudong Su; Yu Lan; Yanzhe Hao; Pierre Formenty; Ute Ströher; Foday Sahr
Journal:  N Engl J Med       Date:  2015-10-14       Impact factor: 91.245

7.  Enhanced methods for unbiased deep sequencing of Lassa and Ebola RNA viruses from clinical and biological samples.

Authors:  Christian B Matranga; Kristian G Andersen; Sarah Winnicki; Michele Busby; Adrianne D Gladden; Ryan Tewhey; Matthew Stremlau; Aaron Berlin; Stephen K Gire; Eleina England; Lina M Moses; Tarjei S Mikkelsen; Ikponmwonsa Odia; Philomena E Ehiane; Onikepe Folarin; Augustine Goba; S Humarr Kahn; Donald S Grant; Anna Honko; Lisa Hensley; Christian Happi; Robert F Garry; Christine M Malboeuf; Bruce W Birren; Andreas Gnirke; Joshua Z Levin; Pardis C Sabeti
Journal:  Genome Biol       Date:  2014       Impact factor: 13.583

8.  Persistence and clearance of Ebola virus RNA from seminal fluid of Ebola virus disease survivors: a longitudinal analysis and modelling study.

Authors:  Daouda Sissoko; Sophie Duraffour; Romy Kerber; Jacques Seraphin Kolie; Abdoul Habib Beavogui; Alseny-Modet Camara; Géraldine Colin; Toni Rieger; Lisa Oestereich; Bernadett Pályi; Stephanie Wurr; Jeremie Guedj; Thi Huyen Tram Nguyen; Rosalind M Eggo; Conall H Watson; W John Edmunds; Joseph Akoi Bore; Fara Raymond Koundouno; Mar Cabeza-Cabrerizo; Lisa L Carter; Liana Eleni Kafetzopoulou; Eeva Kuisma; Janine Michel; Livia Victoria Patrono; Natasha Y Rickett; Katrin Singethan; Martin Rudolf; Angelika Lander; Elisa Pallasch; Sabrina Bockholt; Estefanía Rodríguez; Antonino Di Caro; Roman Wölfel; Martin Gabriel; Céline Gurry; Pierre Formenty; Sakoba Keïta; Denis Malvy; Miles W Carroll; Xavier Anglaret; Stephan Günther
Journal:  Lancet Glob Health       Date:  2017-01       Impact factor: 26.763

9.  Late Ebola virus relapse causing meningoencephalitis: a case report.

Authors:  Michael Jacobs; Alison Rodger; David J Bell; Sanjay Bhagani; Ian Cropley; Ana Filipe; Robert J Gifford; Susan Hopkins; Joseph Hughes; Farrah Jabeen; Ingolfur Johannessen; Drosos Karageorgopoulos; Angie Lackenby; Rebecca Lester; Rebecca S N Liu; Alisdair MacConnachie; Tabitha Mahungu; Daniel Martin; Neal Marshall; Stephen Mepham; Richard Orton; Massimo Palmarini; Monika Patel; Colin Perry; S Erica Peters; Duncan Porter; David Ritchie; Neil D Ritchie; R Andrew Seaton; Vattipally B Sreenu; Kate Templeton; Simon Warren; Gavin S Wilkie; Maria Zambon; Robin Gopal; Emma C Thomson
Journal:  Lancet       Date:  2016-05-18       Impact factor: 79.321

10.  Resurgence of Ebola Virus Disease in Guinea Linked to a Survivor With Virus Persistence in Seminal Fluid for More Than 500 Days.

Authors:  Boubacar Diallo; Daouda Sissoko; Nicholas J Loman; Hadja Aïssatou Bah; Hawa Bah; Mary Claire Worrell; Lya Saidou Conde; Ramata Sacko; Samuel Mesfin; Angelo Loua; Jacques Katomba Kalonda; Ngozi A Erondu; Benjamin A Dahl; Susann Handrick; Ian Goodfellow; Luke W Meredith; Matthew Cotten; Umaru Jah; Raoul Emeric Guetiya Wadoum; Pierre Rollin; N'Faly Magassouba; Denis Malvy; Xavier Anglaret; Miles W Carroll; Raymond Bruce Aylward; Mamoudou Harouna Djingarey; Abdoulaye Diarra; Pierre Formenty; Sakoba Keïta; Stephan Günther; Andrew Rambaut; Sophie Duraffour
Journal:  Clin Infect Dis       Date:  2016-09-01       Impact factor: 9.079
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  10 in total

1.  Longitudinal Human Antibody Repertoire against Complete Viral Proteome from Ebola Virus Survivor Reveals Protective Sites for Vaccine Design.

Authors:  Surender Khurana; Supriya Ravichandran; Megan Hahn; Elizabeth M Coyle; Spencer W Stonier; Samantha E Zak; Jason Kindrachuk; Richard T Davey; John M Dye; Daniel S Chertow
Journal:  Cell Host Microbe       Date:  2020-02-12       Impact factor: 21.023

Review 2.  COVID-19 false dichotomies and a comprehensive review of the evidence regarding public health, COVID-19 symptomatology, SARS-CoV-2 transmission, mask wearing, and reinfection.

Authors:  Kevin Escandón; Angela L Rasmussen; Isaac I Bogoch; Eleanor J Murray; Karina Escandón; Saskia V Popescu; Jason Kindrachuk
Journal:  BMC Infect Dis       Date:  2021-07-27       Impact factor: 3.090

3.  Tolcapone Potently Inhibits Seminal Amyloid Fibrils Formation and Blocks Entry of Ebola Pseudoviruses.

Authors:  Mengjie Qiu; Zhaofeng Li; Yuliu Chen; Jiayin Guo; Wei Xu; Tao Qi; Yurong Qiu; Jianxin Pang; Lin Li; Shuwen Liu; Suiyi Tan
Journal:  Front Microbiol       Date:  2020-04-30       Impact factor: 5.640

Review 4.  Persistence and Sexual Transmission of Filoviruses.

Authors:  Brayden G Schindell; Andrew L Webb; Jason Kindrachuk
Journal:  Viruses       Date:  2018-12-02       Impact factor: 5.048

5.  A 40-Month Follow-Up of Ebola Virus Disease Survivors in Guinea (PostEbogui) Reveals Long-Term Detection of Ebola Viral Ribonucleic Acid in Semen and Breast Milk.

Authors:  Alpha Kabinet Keita; Nicole Vidal; Abdoulaye Toure; Mamadou Saliou Kalifa Diallo; N'fally Magassouba; Sylvain Baize; Mathieu Mateo; Herve Raoul; Stephane Mely; Fabien Subtil; Cécé Kpamou; Lamine Koivogui; Falaye Traore; Mamadou Saliou Sow; Ahidjo Ayouba; Jean Francois Etard; Eric Delaporte; Martine Peeters
Journal:  Open Forum Infect Dis       Date:  2019-11-08       Impact factor: 3.835

Review 6.  Implications of RNA Viruses in the Male Reproductive Tract: An Outlook on SARS-CoV-2.

Authors:  Mohammad Ishraq Zafar; Jiangyu Yu; Honggang Li
Journal:  Front Microbiol       Date:  2021-12-24       Impact factor: 5.640

7.  Active Ebola Virus Replication and Heterogeneous Evolutionary Rates in EVD Survivors.

Authors:  Shannon L M Whitmer; Jason T Ladner; Michael R Wiley; Ketan Patel; Gytis Dudas; Andrew Rambaut; Foday Sahr; Karla Prieto; Samuel S Shepard; Ellie Carmody; Barbara Knust; Dhamari Naidoo; Gibrilla Deen; Pierre Formenty; Stuart T Nichol; Gustavo Palacios; Ute Ströher
Journal:  Cell Rep       Date:  2018-01-30       Impact factor: 9.423

8.  Herd Immunity to Ebolaviruses Is Not a Realistic Target for Current Vaccination Strategies.

Authors:  Stuart G Masterson; Leslie Lobel; Miles W Carroll; Mark N Wass; Martin Michaelis
Journal:  Front Immunol       Date:  2018-05-09       Impact factor: 7.561

Review 9.  Advances in Designing and Developing Vaccines, Drugs, and Therapies to Counter Ebola Virus.

Authors:  Kuldeep Dhama; Kumaragurubaran Karthik; Rekha Khandia; Sandip Chakraborty; Ashok Munjal; Shyma K Latheef; Deepak Kumar; Muthannan Andavar Ramakrishnan; Yashpal Singh Malik; Rajendra Singh; Satya Veer Singh Malik; Raj Kumar Singh; Wanpen Chaicumpa
Journal:  Front Immunol       Date:  2018-08-10       Impact factor: 7.561

10.  Modeling Challenges of Ebola Virus-Host Dynamics during Infection and Treatment.

Authors:  Daniel S Chertow; Louis Shekhtman; Yoav Lurie; Richard T Davey; Theo Heller; Harel Dahari
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