| Literature DB >> 28582036 |
Kenta Nakamura1, John H Keating2, Elazer Reuven Edelman3.
Abstract
Contemporary endovascular stents are the product of an iterative design and development process that leverages evolving concepts in vascular biology and engineering. This article reviews how insights into vascular pathophysiology, materials science, and design mechanics drive stent design and explain modes of stent failure. Current knowledge of pathologic processes is providing a more complete picture of the factors mediating stent failure. Further evolution of endovascular stents includes bioresorbable platforms tailored to treat plaques acutely and to then disappear after lesion pacification. Ongoing refinement of stent technology will continue to require insights from pathology to understand adverse events, refine clinical protocols, and drive innovation.Entities:
Keywords: Atherosclerosis; Bare metal stent; Coronary artery disease; Drug-eluting stent; In-stent restenosis; In-stent thrombosis; Neoatherosclerosis; Pathology
Mesh:
Year: 2016 PMID: 28582036 PMCID: PMC6588793 DOI: 10.1016/j.iccl.2016.02.006
Source DB: PubMed Journal: Interv Cardiol Clin ISSN: 2211-7458