C Xhaard1, A Dumas1, V Souchard1, Y Ren1, F Borson-Chazot2, G Sassolas3, C Schvartz4, M Colonna5, B Lacour6, A S Wonoroff7, M Velten8, E Clero1, S Maillard1, E Marrer9, L Bailly10, E Mariné Barjoan10, M Schlumberger11, J Orgiazzi12, E Adjadj13, C Rubino1, A Bouville14, V Drozdovitch14, F de Vathaire15. 1. Centre d'épidémiologie et de santé des populations (Cesp), U1018, epidemiology radiation group, Institut national de la santé et de la recherche médicale (Inserm), 94800 Villejuif, France; Gustave-Roussy, 94800 Villejuif, France; Université Paris-Saclay, 94800 Villejuif, France. 2. Fédération d'endocrinologie, hospices civils de Lyon, groupement hospitalier Lyon-Est, 69677 Bron, France; Rhône-Alpes thyroid cancer registry, cancer research center of Lyon (UMR Inserm 1052, CNRS 5286), RTH Laennec faculty of medicine, university of Lyon, 69008 Lyon, France. 3. Rhône-Alpes thyroid cancer registry, cancer research center of Lyon (UMR Inserm 1052, CNRS 5286), RTH Laennec faculty of medicine, university of Lyon, 69008 Lyon, France. 4. Thyroid cancer registry of Champagne-Ardennes, institut Jean-Godinot, 51100 Reims, France. 5. Cancer registry of Isère, 38240 Meylan, France. 6. French national registry of childhood solid tumours, CHU de Nancy, 54505 Vandœuvre, France; Inserm UMRS1018, CESP, 94800 Villejuif, France. 7. Cancer registry of doubs, EA 3181, university hospital Besançon, 25030 Besançon, France. 8. Cancer Registry of Bas-Rhin, EA 3430, faculty of medicine, university of Strasbourg, 67085 Strasbourg, France. 9. Cancer registry of Haut-Rhin, Mulhouse hospital, 68051 Mulhouse, France. 10. Public health department, university hospital Nice, 06202 Nice, France. 11. Gustave-Roussy, 94800 Villejuif, France. 12. Department of endocrinology, Hospices civils de Lyon, 69310 Lyon, France. 13. Centre d'épidémiologie et de santé des populations (Cesp), U1018, epidemiology radiation group, Institut national de la santé et de la recherche médicale (Inserm), 94800 Villejuif, France; Université Paris-Saclay, 94800 Villejuif, France. 14. Radiation epidemiology branch, division of cancer epidemiology and genetics, national cancer institute, Bethesda, USA. 15. Centre d'épidémiologie et de santé des populations (Cesp), U1018, epidemiology radiation group, Institut national de la santé et de la recherche médicale (Inserm), 94800 Villejuif, France; Gustave-Roussy, 94800 Villejuif, France; Université Paris-Saclay, 94800 Villejuif, France. Electronic address: florent.devathaire@gustaveroussy.fr.
Abstract
BACKGROUND: In retrospective case-control studies performed following nuclear tests or nuclear accidents, individual thyroid radiation dose reconstructions are based on fallout and meteorological data from the residential area, demographic characteristics, and lifestyle as well as dietary information. Collecting the latter is a controversial step, as dietary declarations may be affected by the subjects' beliefs about their risk behavior. This report analyses the potential for such bias in a case-control study performed in eastern France. METHODS: The study included 765 cases of differentiated thyroid carcinoma matched with 831 controls. Risk perceptions and beliefs of cases and controls were compared using Chi2 tests and differences in dietary reports were analyzed using a two-way ANOVA. RESULTS: In general, atmospheric pollution and living near a nuclear power plant were the two major risks that may influence thyroid cancer occurrence cited by cases and controls. When focusing in particular on the consequences of the Chernobyl accident, cases were more likely to think that the consequences were responsible for thyroid cancer occurrence than controls. Vegetable consumption during the two months after the Chernobyl accident was correlated with the status of subjects, but not to their beliefs. Conversely, consumption of fresh dairy products was not correlated with the status or beliefs of subjects. CONCLUSION: We found no evidence of systematic bias in dietary reports according to the status or beliefs held by subjects about the link between thyroid cancer occurrence and Chernobyl fallout. As such, these dietary reports may be used in further studies involving individual dosimetric reconstructions.
BACKGROUND: In retrospective case-control studies performed following nuclear tests or nuclear accidents, individual thyroid radiation dose reconstructions are based on fallout and meteorological data from the residential area, demographic characteristics, and lifestyle as well as dietary information. Collecting the latter is a controversial step, as dietary declarations may be affected by the subjects' beliefs about their risk behavior. This report analyses the potential for such bias in a case-control study performed in eastern France. METHODS: The study included 765 cases of differentiated thyroid carcinoma matched with 831 controls. Risk perceptions and beliefs of cases and controls were compared using Chi2 tests and differences in dietary reports were analyzed using a two-way ANOVA. RESULTS: In general, atmospheric pollution and living near a nuclear power plant were the two major risks that may influence thyroid cancer occurrence cited by cases and controls. When focusing in particular on the consequences of the Chernobyl accident, cases were more likely to think that the consequences were responsible for thyroid cancer occurrence than controls. Vegetable consumption during the two months after the Chernobyl accident was correlated with the status of subjects, but not to their beliefs. Conversely, consumption of fresh dairy products was not correlated with the status or beliefs of subjects. CONCLUSION: We found no evidence of systematic bias in dietary reports according to the status or beliefs held by subjects about the link between thyroid cancer occurrence and Chernobyl fallout. As such, these dietary reports may be used in further studies involving individual dosimetric reconstructions.
Authors: Jacques Ferlay; Hai-Rim Shin; Freddie Bray; David Forman; Colin Mathers; Donald Maxwell Parkin Journal: Int J Cancer Date: 2010-12-15 Impact factor: 7.396
Authors: E Ron; J H Lubin; R E Shore; K Mabuchi; B Modan; L M Pottern; A B Schneider; M A Tucker; J D Boice Journal: Radiat Res Date: 1995-03 Impact factor: 2.841
Authors: Constance Xhaard; Carole Rubino; Vincent Souchard; Stéphane Maillard; Yan Ren; Françoise Borson-Chazot; Geneviève Sassolas; Claire Schvartz; Marc Colonna; Brigitte Lacour; Anne Sophie Woronoff; Michel Velten; Emilie Marrer; Laurent Bailly; Eugènia Mariné Barjoan; Martin Schlumberger; Vladimir Drozdovitch; Andre Bouville; Jacques Orgiazzi; Elisabeth Adjadj; Florent de Vathaire Journal: Cancer Epidemiol Date: 2018-01-08 Impact factor: 2.890