Constance Xhaard1, Carole Rubino1, Vincent Souchard1, Stéphane Maillard1, Yan Ren1, Françoise Borson-Chazot2, Geneviève Sassolas3, Claire Schvartz4, Marc Colonna5, Brigitte Lacour6, Anne Sophie Woronoff7, Michel Velten8, Emilie Marrer9, Laurent Bailly10, Eugènia Mariné Barjoan10, Martin Schlumberger11, Vladimir Drozdovitch12, Andre Bouville12, Jacques Orgiazzi2, Elisabeth Adjadj1, Florent de Vathaire13. 1. Inserm, Center for Research in Epidemiology and Population Health (CESP), U1018, Radiation Epidemiology Group, Villejuif, F-94805, France; Gustave Roussy, Villejuif, F-94805, France; University of Paris-Sud, Villejuif, F-94800, France. 2. Lyon University Hospital, Lyon, France. 3. Thyroid Cancer Registry of Rhone-Alpes, Lyon, France. 4. Thyroid Cancer Registry of Champagne-Ardennes, France. 5. Cancer Registry of Isère, France. 6. French National Childhood Solid Cancer Registry, CHU Nancy, France. 7. Doubs Cancer Registry, CHU Besançon, France. 8. Cancer Registry of Bas-Rhin, Strasbourg, France. 9. Cancer Registry of Haut-Rhin, Mulhouse, France. 10. Public Health Department, University Hospital Nice, France. 11. Gustave Roussy, Villejuif, F-94805, France. 12. US National Cancer Institute, Bethesda, USA. 13. Inserm, Center for Research in Epidemiology and Population Health (CESP), U1018, Radiation Epidemiology Group, Villejuif, F-94805, France; Gustave Roussy, Villejuif, F-94805, France; University of Paris-Sud, Villejuif, F-94800, France. Electronic address: florent.devathaire@gustaveroussy.fr.
Abstract
BACKGROUND: The Chernobyl nuclear power plant accident occurred in Ukraine on April 26th 1986. In France, the radioactive fallout and thyroid radiation doses were much lower than in highly contaminated areas. However, a number of risk projections have suggested that a small excess in differentiated thyroid cancer (DTC) might occur in eastern France due to this low-level fallout. In order to investigate this potential impact, a case-control study on DTC risk factors was started in 2005, focusing on cases who were less than 15 years old at the time of the Chernobyl accident. Here, we aim to evaluate the relationship between some specific reports of potentially contaminated food between April and June 1986 - in particular fresh dairy products and leafy vegetables - and DTC risk. METHODS: After excluding subjects who were not born before the Chernobyl accident, the study included 747 cases of DTC matched with 815 controls. Odds ratios were calculated using conditional logistic regression models and were reported for all participants, for women only, for papillary cancer only, and excluding microcarcinomas. RESULTS: The DTC risk was slightly higher for participants who had consumed locally produced leafy vegetables. However, this association was not stronger in the more contaminated areas than in the others. Conversely, the reported consumption of fresh dairy products was not statistically associated with DTC risk. CONCLUSION: Because the increase in DTC risk associated with a higher consumption of locally produced vegetables was not more important in the most contaminated areas, our study lacked power to provide evidence for a strong association between consumption of potentially contaminated food and DTC risk.
BACKGROUND: The Chernobyl nuclear power plant accident occurred in Ukraine on April 26th 1986. In France, the radioactive fallout and thyroid radiation doses were much lower than in highly contaminated areas. However, a number of risk projections have suggested that a small excess in differentiated thyroid cancer (DTC) might occur in eastern France due to this low-level fallout. In order to investigate this potential impact, a case-control study on DTC risk factors was started in 2005, focusing on cases who were less than 15 years old at the time of the Chernobyl accident. Here, we aim to evaluate the relationship between some specific reports of potentially contaminated food between April and June 1986 - in particular fresh dairy products and leafy vegetables - and DTC risk. METHODS: After excluding subjects who were not born before the Chernobyl accident, the study included 747 cases of DTC matched with 815 controls. Odds ratios were calculated using conditional logistic regression models and were reported for all participants, for women only, for papillary cancer only, and excluding microcarcinomas. RESULTS: The DTC risk was slightly higher for participants who had consumed locally produced leafy vegetables. However, this association was not stronger in the more contaminated areas than in the others. Conversely, the reported consumption of fresh dairy products was not statistically associated with DTC risk. CONCLUSION: Because the increase in DTC risk associated with a higher consumption of locally produced vegetables was not more important in the most contaminated areas, our study lacked power to provide evidence for a strong association between consumption of potentially contaminated food and DTC risk.
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