Stefan Michiels1,2,3, Everardo D Saad4, Marc Buyse5,6. 1. Gustave Roussy, Service de Biostatistique et d'Epidémiologie, Villejuif, 94805, France. Stefan.MICHIELS@gustaveroussy.fr. 2. Université Paris-Saclay, Université Paris-Sud, UVSQ, CESP, INSERM U1018, Villejuif, 94805, France. Stefan.MICHIELS@gustaveroussy.fr. 3. Gustave Roussy, Ligue Nationale Contre le Cancer Meta-Analysis Platform, Villejuif, 94805, France. Stefan.MICHIELS@gustaveroussy.fr. 4. International Drug Development Institute (IDDI), Louvain-la-Neuve, Belgium. 5. Interuniversity Institute for Biostatistics and statistical Bioinformatics (I-BioStat), Hasselt University, Hasselt, Belgium. 6. International Drug Development Institute (IDDI), San Francisco, CA, USA.