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Literature DB >> 28573367

3D Microfabricated Scaffolds and Microfluidic Devices for Ocular Surface Replacement: a Review.

Elisabetta Prina¹, Pritesh Mistry¹, Laura E Sidney², Jing Yang¹, Ricky D Wildman³, Marina Bertolin⁴, Claudia Breda⁴, Barbara Ferrari⁴, Vanessa Barbaro⁴, Andrew Hopkinson², Harminder S Dua², Stefano Ferrari⁵, Felicity R A J Rose¹.

Abstract

In recent years, there has been increased research interest in generating corneal substitutes, either for use in the clinic or as in vitro corneal models. The advancement of 3D microfabrication technologies has allowed the reconstruction of the native microarchitecture that controls epithelial cell adhesion, migration and differentiation. In addition, such technology has allowed the inclusion of a dynamic fluid flow that better mimics the physiology of the native cornea. We review the latest innovative products in development in this field, from 3D microfabricated hydrogels to microfluidic devices.

Keywords: 3D model; Cornea; Microfabrication; Microfluidics; Topography

Mesh：

Substances：
Hydrogels

Year: 2017 PMID： 28573367 DOI： 10.1007/s12015-017-9740-6

Source DB: PubMed Journal: Stem Cell Rev Rep ISSN： 2629-3277 Impact factor: 5.739

104 in total

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Authors: Isobel Massie; Hannah J Levis; Julie T Daniels
Journal: Exp Eye Res Date: 2014-08-07 Impact factor: 3.467