Literature DB >> 28553942

Digital-to-biological converter for on-demand production of biologics.

Kent S Boles1, Krishna Kannan1, John Gill1, Martina Felderman1, Heather Gouvis1, Bolyn Hubby1, Kurt I Kamrud1, J Craig Venter1, Daniel G Gibson1.   

Abstract

Manufacturing processes for biological molecules in the research laboratory have failed to keep pace with the rapid advances in automization and parellelization. We report the development of a digital-to-biological converter for fully automated, versatile and demand-based production of functional biologics starting from DNA sequence information. Specifically, DNA templates, RNA molecules, proteins and viral particles were produced in an automated fashion from digitally transmitted DNA sequences without human intervention.

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Year:  2017        PMID： 28553942     DOI： 10.1038/nbt.3859

Source DB:  PubMed          Journal:  Nat Biotechnol        ISSN： 1087-0156            Impact factor:   54.908


  17 in total

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7.  Design and synthesis of a minimal bacterial genome.

Authors:  Clyde A Hutchison; Ray-Yuan Chuang; Vladimir N Noskov; Nacyra Assad-Garcia; Thomas J Deerinck; Mark H Ellisman; John Gill; Krishna Kannan; Bogumil J Karas; Li Ma; James F Pelletier; Zhi-Qing Qi; R Alexander Richter; Elizabeth A Strychalski; Lijie Sun; Yo Suzuki; Billyana Tsvetanova; Kim S Wise; Hamilton O Smith; John I Glass; Chuck Merryman; Daniel G Gibson; J Craig Venter
Journal:  Science       Date:  2016-03-25       Impact factor: 47.728

8.  Synthesis of many different types of organic small molecules using one automated process.

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10.  JCat: a novel tool to adapt codon usage of a target gene to its potential expression host.

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Journal:  Nucleic Acids Res       Date:  2005-07-01       Impact factor: 16.971
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  9 in total

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Journal:  J Ind Microbiol Biotechnol       Date:  2018-06-18       Impact factor: 3.346

Review 2.  Synthetic chromosomes, genomes, viruses, and cells.

Authors:  J Craig Venter; John I Glass; Clyde A Hutchison; Sanjay Vashee
Journal:  Cell       Date:  2022-07-21       Impact factor: 66.850

3.  A framework to efficiently describe and share reproducible DNA materials and construction protocols.

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Journal:  Nat Commun       Date:  2022-05-24       Impact factor: 17.694

4.  Evolutionary tinkering vs. rational engineering in the times of synthetic biology.

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5.  On-demand biomanufacturing of protective conjugate vaccines.

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Review 6.  Bacterial cell-free expression technology to in vitro systems engineering and optimization.

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Journal:  Synth Syst Biotechnol       Date:  2017-08-07

Review 7.  A review of computational tools for design and reconstruction of metabolic pathways.

Authors:  Lin Wang; Satyakam Dash; Chiam Yu Ng; Costas D Maranas
Journal:  Synth Syst Biotechnol       Date:  2017-11-15

8.  On-demand manufacturing of clinical-quality biopharmaceuticals.

Authors:  Laura E Crowell; Amos E Lu; Kerry R Love; Alan Stockdale; Steven M Timmick; Di Wu; Yu Annie Wang; William Doherty; Alexandra Bonnyman; Nicholas Vecchiarello; Chaz Goodwine; Lisa Bradbury; Joseph R Brady; John J Clark; Noelle A Colant; Aleksandar Cvetkovic; Neil C Dalvie; Diana Liu; Yanjun Liu; Craig A Mascarenhas; Catherine B Matthews; Nicholas J Mozdzierz; Kartik A Shah; Shiaw-Lin Wu; William S Hancock; Richard D Braatz; Steven M Cramer; J Christopher Love
Journal:  Nat Biotechnol       Date:  2018-10-01       Impact factor: 54.908

Review 9.  Biotechnology Applications of Cell-Free Expression Systems.

Authors:  August Brookwell; Javin P Oza; Filippo Caschera
Journal:  Life (Basel)       Date:  2021-12-08
  9 in total

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