Literature DB >> 28551725

Colorectal cancer molecular profiling: from IHC to NGS in search of optimal algorithm.

Larissa V Furtado1, Wade S Samowitz2.   

Abstract

Advances in defining the mutational landscape of colorectal cancer (CRC) over the past decades have revolutionized the molecular understanding and clinical testing algorithms for this disease. Mutation testing is standard of care for the work-up of CRCs. This review focuses on the current indications and strategies for molecular testing in CRC and discusses the potential changes in CRC testing approach associated with the emerging clinical application of genomic-based technologies.

Entities:  

Keywords:  Biomarker; Colorectal cancer; IHC; Lynch syndrome; Next-generation sequencing; Personalized medicine

Mesh：

Substances：

Year:  2017        PMID： 28551725     DOI： 10.1007/s00428-017-2153-8

Source DB:  PubMed          Journal:  Virchows Arch        ISSN： 0945-6317            Impact factor:   4.064


  66 in total

1.  NCCN increases the emphasis on genetic/familial high-risk assessment in colorectal cancer.

Authors:  Heather Hampel
Journal:  J Natl Compr Canc Netw       Date:  2014-05       Impact factor: 11.908

Review 2.  Evaluation of colorectal cancers for Lynch syndrome: practical molecular diagnostics for surgical pathologists.

Authors:  Wade S Samowitz
Journal:  Mod Pathol       Date:  2015-01       Impact factor: 7.842

3.  BRAFV600E immunohistochemistry facilitates universal screening of colorectal cancers for Lynch syndrome.

Authors:  Christopher W Toon; Michael D Walsh; Angela Chou; David Capper; Adele Clarkson; Loretta Sioson; Stephen Clarke; Scott Mead; Rhiannon J Walters; Mark Clendenning; Christophe Rosty; Joanne P Young; Aung Ko Win; John L Hopper; Ashley Crook; Andreas von Deimling; Mark A Jenkins; Daniel D Buchanan; Anthony J Gill
Journal:  Am J Surg Pathol       Date:  2013-10       Impact factor: 6.394

4.  Detection of Mismatch Repair Deficiency and Microsatellite Instability in Colorectal Adenocarcinoma by Targeted Next-Generation Sequencing.

Authors:  Jonathan A Nowak; Matthew B Yurgelun; Jacqueline L Bruce; Vanesa Rojas-Rudilla; Dimity L Hall; Priyanka Shivdasani; Elizabeth P Garcia; Agoston T Agoston; Amitabh Srivastava; Shuji Ogino; Frank C Kuo; Neal I Lindeman; Fei Dong
Journal:  J Mol Diagn       Date:  2016-11-15       Impact factor: 5.568

Review 5.  The epidermal growth factor receptor pathway: a model for targeted therapy.

Authors:  Maurizio Scaltriti; José Baselga
Journal:  Clin Cancer Res       Date:  2006-09-15       Impact factor: 12.531

6.  Mutation analysis of the BRAF, ARAF and RAF-1 genes in human colorectal adenocarcinomas.

Authors:  Karin Fransén; Maria Klintenäs; Anna Osterström; Jan Dimberg; Hans-Jürg Monstein; Peter Söderkvist
Journal:  Carcinogenesis       Date:  2003-12-19       Impact factor: 4.944

7.  Prognostic role of KRAS and BRAF in stage II and III resected colon cancer: results of the translational study on the PETACC-3, EORTC 40993, SAKK 60-00 trial.

Authors:  Arnaud D Roth; Sabine Tejpar; Mauro Delorenzi; Pu Yan; Roberto Fiocca; Dirk Klingbiel; Daniel Dietrich; Bart Biesmans; György Bodoky; Carlo Barone; Enrique Aranda; Bernard Nordlinger; Laura Cisar; Roberto Labianca; David Cunningham; Eric Van Cutsem; Fred Bosman
Journal:  J Clin Oncol       Date:  2009-12-14       Impact factor: 44.544

Review 8.  Chemotherapy of MMR-deficient colorectal cancer.

Authors:  N Devaud; S Gallinger
Journal:  Fam Cancer       Date:  2013-06       Impact factor: 2.375

9.  Immunohistochemistry versus microsatellite instability testing for screening colorectal cancer patients at risk for hereditary nonpolyposis colorectal cancer syndrome. Part I. The utility of immunohistochemistry.

Authors:  Jinru Shia
Journal:  J Mol Diagn       Date:  2008-06-13       Impact factor: 5.568

10.  Applicability of next generation sequencing technology in microsatellite instability testing.

Authors:  Chun Gan; Clare Love; Victoria Beshay; Finlay Macrae; Stephen Fox; Paul Waring; Graham Taylor
Journal:  Genes (Basel)       Date:  2015-02-12       Impact factor: 4.096
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  2 in total

1.  Patterns of germline and somatic mutations in 16 genes associated with mismatch repair function or containing tandem repeat sequences.

Authors:  Shih-Ching Chang; Yuan-Tzu Lan; Pei-Ching Lin; Shung-Haur Yang; Chien-Hsing Lin; Wen-Yi Liang; Wei-Shone Chen; Jeng-Kai Jiang; Jen-Kou Lin
Journal:  Cancer Med       Date:  2019-11-25       Impact factor: 4.452

2.  Molecular characteristics of colorectal cancer in a Middle Eastern population in a single institution.

Authors:  Tony Ibrahim; Claude Saer-Ghorra; Vivane Trak-Smayra; Samah Nadiri; Charbel Yazbeck; Maria Baz; Joseph G Kattan
Journal:  Ann Saudi Med       Date:  2018 Jul-Aug       Impact factor: 1.526
  2 in total

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