Literature DB >> 23539382

Chemotherapy of MMR-deficient colorectal cancer.

N Devaud1, S Gallinger.   

Abstract

Colorectal cancer (CRC) continues to rank as the third most common cancer in Western society and the second leading cause of cancer death in North America. There are at least three distinct, and relatively discreet, molecular pathways associated with this disease: chromosomal instability (CIN), microsatellite instability (MSI) and the cytosine polyguanine island methylator phenotype. Defects in the DNA mismatch repair system (MMR) account for the MSI phenotype and genotype of about 15 % of CRC. Although high frequency MSI tumors have better stage independent prognosis compared to those with CIN, MMR deficient CRC appears to be resistant to fluorouracil based treatment, but sensitive to other therapeutic regimens. This review summarises current literature on differential chemosensitivity of MMR-deficient CRC.

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Year:  2013        PMID： 23539382     DOI： 10.1007/s10689-013-9633-z

Source DB:  PubMed          Journal:  Fam Cancer        ISSN： 1389-9600            Impact factor:   2.375


  52 in total

1.  Differential induction of c-Jun NH2-terminal kinase and c-Abl kinase in DNA mismatch repair-proficient and -deficient cells exposed to cisplatin.

Authors:  A Nehmé; R Baskaran; S Aebi; D Fink; S Nebel; B Cenni; J Y Wang; S B Howell; R D Christen
Journal:  Cancer Res       Date:  1997-08-01       Impact factor: 12.701

2.  Cancer statistics, 1999.

Authors:  S H Landis; T Murray; S Bolden; P A Wingo
Journal:  CA Cancer J Clin       Date:  1999 Jan-Feb       Impact factor: 508.702

3.  The role of the DNA mismatch repair system in the cytotoxicity of the topoisomerase inhibitors camptothecin and etoposide to human colorectal cancer cells.

Authors:  S Jacob; M Aguado; D Fallik; F Praz
Journal:  Cancer Res       Date:  2001-09-01       Impact factor: 12.701

4.  Somatic frameshift mutations in the BAX gene in colon cancers of the microsatellite mutator phenotype.

Authors:  N Rampino; H Yamamoto; Y Ionov; Y Li; H Sawai; J C Reed; M Perucho
Journal:  Science       Date:  1997-02-14       Impact factor: 47.728

Review 5.  Metabolism and mechanism of action of 5-fluorouracil.

Authors:  W B Parker; Y C Cheng
Journal:  Pharmacol Ther       Date:  1990       Impact factor: 12.310

6.  Response to 5-fluorouracil of orthotopically xenografted human colon cancers with a microsatellite instability: influence of P53 status.

Authors:  M Pocard; R Bras-Gonçalves; R Hamelin; J Northover; M F Poupon
Journal:  Anticancer Res       Date:  2000 Jan-Feb       Impact factor: 2.480

7.  Molecular characterization of MSI-H colorectal cancer by MLHI promoter methylation, immunohistochemistry, and mismatch repair germline mutation screening.

Authors:  Jenny N Poynter; Kimberly D Siegmund; Daniel J Weisenberger; Tiffany I Long; Stephen N Thibodeau; Noralane Lindor; Joanne Young; Mark A Jenkins; John L Hopper; John A Baron; Dan Buchanan; Graham Casey; A Joan Levine; Loïc Le Marchand; Steven Gallinger; Bharati Bapat; John D Potter; Polly A Newcomb; Robert W Haile; Peter W Laird
Journal:  Cancer Epidemiol Biomarkers Prev       Date:  2008-11       Impact factor: 4.254

8.  Impact of p53 expression and microsatellite instability on stage III colon cancer disease-free survival in patients treated by 5-fluorouracil and leucovorin with or without oxaliplatin.

Authors:  A Zaanan; P Cuilliere-Dartigues; A Guilloux; Y Parc; C Louvet; A de Gramont; E Tiret; S Dumont; B Gayet; P Validire; J-F Fléjou; A Duval; F Praz
Journal:  Ann Oncol       Date:  2009-10-15       Impact factor: 32.976

9.  Morphology of sporadic colorectal cancer with DNA replication errors.

Authors:  J R Jass; K A Do; L A Simms; H Iino; C Wynter; S P Pillay; J Searle; G Radford-Smith; J Young; B Leggett
Journal:  Gut       Date:  1998-05       Impact factor: 23.059

10.  Methotrexate induces oxidative DNA damage and is selectively lethal to tumour cells with defects in the DNA mismatch repair gene MSH2.

Authors:  Sarah A Martin; Afshan McCarthy; Louise J Barber; Darren J Burgess; Suzanne Parry; Christopher J Lord; Alan Ashworth
Journal:  EMBO Mol Med       Date:  2009-09       Impact factor: 12.137
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  28 in total

1.  [Expression of secreted frizzled-related protein 4 in DNA mismatch repair-deficient and mismatch repair-proficient colorectal cancers].

Authors:  Kexu Chen; Hanlin Liang; Jiewen Peng; Yanfang Zheng
Journal:  Nan Fang Yi Ke Da Xue Xue Bao       Date:  2018-11-30

Review 2.  Biomarkers for immune therapy in colorectal cancer: mismatch-repair deficiency and others.

Authors:  Manojkumar Bupathi; Christina Wu
Journal:  J Gastrointest Oncol       Date:  2016-10

3.  The Long-term Impact of Roux-en-Y Gastric Bypass on Colorectal Polyp Formation and Relation to Weight Loss Outcomes.

Authors:  Hisham Hussan; Alyssa Drosdak; Melissa Le Roux; Kishan Patel; Kyle Porter; Steven K Clinton; Brian Focht; Sabrena Noria
Journal:  Obes Surg       Date:  2020-02       Impact factor: 4.129

4.  Association between mismatch repair gene and irinotecan-based chemotherapy in metastatic colon cancer.

Authors:  Junli Ma; Yan Zhang; Hong Shen; Linda Kapesa; Wenqiang Liu; Mengsi Zeng; Shan Zeng
Journal:  Tumour Biol       Date:  2015-07-05

5.  CD274, LAG3, and IDO1 expressions in tumor-infiltrating immune cells as prognostic biomarker for patients with MSI-high colon cancer.

Authors:  Soo Jung Lee; Sun-Young Jun; In Hee Lee; Byung Woog Kang; Su Yeon Park; Hye Jin Kim; Jun Seok Park; Gyu-Seog Choi; Ghilsuk Yoon; Jong Gwang Kim
Journal:  J Cancer Res Clin Oncol       Date:  2018-03-08       Impact factor: 4.553

6.  The prognostic significance of polymorphisms in hMLH1/hMSH2 for colorectal cancer.

Authors:  Yibaina Wang; Guangxiao Li; Fulan Hu; Haoran Bi; Zhiwei Wu; Xiaojuan Zhao; Ye Li; Shuying Li; Dandan Li; Binbin Cui; Xinshu Dong; Yashuang Zhao
Journal:  Med Oncol       Date:  2014-05-04       Impact factor: 3.064

Review 7.  Colorectal cancer molecular profiling: from IHC to NGS in search of optimal algorithm.

Authors:  Larissa V Furtado; Wade S Samowitz
Journal:  Virchows Arch       Date:  2017-05-27       Impact factor: 4.064

Review 8.  Clinical significance of microsatellite instability in colorectal cancer.

Authors:  Matthias Kloor; Laura Staffa; Aysel Ahadova; Magnus von Knebel Doeberitz
Journal:  Langenbecks Arch Surg       Date:  2013-09-19       Impact factor: 3.445

Review 9.  Genetic and epigenetic biomarkers for diagnosis, prognosis and treatment of colorectal cancer.

Authors:  Fabio Coppedè; Angela Lopomo; Roberto Spisni; Lucia Migliore
Journal:  World J Gastroenterol       Date:  2014-01-28       Impact factor: 5.742

10.  A Novel Chemotherapeutic Agent to Treat Tumors with DNA Mismatch Repair Deficiencies.

Authors:  Yongliang Zhang; Jennifer T Fox; Young-Un Park; Gene Elliott; Ganesha Rai; Mengli Cai; Srilatha Sakamuru; Ruili Huang; Menghang Xia; Kyeryoung Lee; Min Ho Jeon; Bijoy P Mathew; Hee Dong Park; Winfried Edelmann; Chan Young Park; Sung You Hong; David Maloney; Kyungjae Myung
Journal:  Cancer Res       Date:  2016-06-04       Impact factor: 12.701
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