Eileen Morgan1,2, Catherine R Black1,2, Noina Abid3, Christopher R Cardwell2, David R McCance4, Christopher C Patterson1,2. 1. UKCRC Centre of Excellence for Public Health NI, Queen's University Belfast, Belfast, UK. 2. Centre for Public Health, Queen's University Belfast, Belfast, UK. 3. Paediatric Endocrinology Department, Royal Belfast Hospital for Sick Children, Belfast, UK. 4. Regional Centre for Endocrinology and Diabetes, Royal Victoria Hospital, Belfast, UK.
Abstract
OBJECTIVE: To investigate long-term mortality rates and causes of death in individuals diagnosed with type 1 diabetes before the age of 15 years during the period 1989-2012 or known to paediatric diabetes teams in 1989, in Northern Ireland. METHODS: A cohort of 3129 patients from the Northern Ireland Childhood Diabetes Register was linked to death registrations and underlying causes, coded according to ICD-9 or ICD-10. Standardized mortality ratios (SMRs) were calculated as the ratio of observed to expected deaths by sex, attained age, time since diagnosis, calendar period, and cause of death. RESULTS: Subjects were followed to December 31, 2012 giving 39 764 person-years of follow-up (median 12.1 years). In total, 59 subjects had died (1.5 per 1000 person-years) compared with 19.9 deaths expected, an SMR of 296 (95% confidence interval (CI) 229-382). Women had a significantly higher excess risk of mortality than men with SMRs of 535 (95% CI 361-764) and 203 (95% CI 136-291), respectively. Over half of the deaths (56%) were judged to be related or possibly related to diabetes with most of these due to acute (n = 24) or late (n = 6) complications. CONCLUSIONS: Subjects with type 1 diabetes diagnosed less than 15 years of age had 3 times the mortality risk of the general population. Over half of the deaths were related to acute or chronic complications of diabetes.
OBJECTIVE: To investigate long-term mortality rates and causes of death in individuals diagnosed with type 1 diabetes before the age of 15 years during the period 1989-2012 or known to paediatric diabetes teams in 1989, in Northern Ireland. METHODS: A cohort of 3129 patients from the Northern Ireland Childhood Diabetes Register was linked to death registrations and underlying causes, coded according to ICD-9 or ICD-10. Standardized mortality ratios (SMRs) were calculated as the ratio of observed to expected deaths by sex, attained age, time since diagnosis, calendar period, and cause of death. RESULTS: Subjects were followed to December 31, 2012 giving 39 764 person-years of follow-up (median 12.1 years). In total, 59 subjects had died (1.5 per 1000 person-years) compared with 19.9 deaths expected, an SMR of 296 (95% confidence interval (CI) 229-382). Women had a significantly higher excess risk of mortality than men with SMRs of 535 (95% CI 361-764) and 203 (95% CI 136-291), respectively. Over half of the deaths (56%) were judged to be related or possibly related to diabetes with most of these due to acute (n = 24) or late (n = 6) complications. CONCLUSIONS: Subjects with type 1 diabetes diagnosed less than 15 years of age had 3 times the mortality risk of the general population. Over half of the deaths were related to acute or chronic complications of diabetes.
Authors: Araz Rawshani; Naveed Sattar; Stefan Franzén; Aidin Rawshani; Andrew T Hattersley; Ann-Marie Svensson; Björn Eliasson; Soffia Gudbjörnsdottir Journal: Lancet Date: 2018-08-09 Impact factor: 79.321
Authors: Wei Peng; Jinna Yuan; Valentina Chiavaroli; Guanping Dong; Ke Huang; Wei Wu; Rahim Ullah; Binghan Jin; Hu Lin; José G B Derraik; Junfen Fu Journal: Front Endocrinol (Lausanne) Date: 2021-04-27 Impact factor: 5.555
Authors: Jean M Lawrence; Kristi Reynolds; Sharon H Saydah; Amy Mottl; Catherine Pihoker; Dana Dabelea; Lawrence Dolan; Leora Henkin; Angela D Liese; Scott Isom; Jasmin Divers; Lynne Wagenknecht Journal: Diabetes Care Date: 2021-10-04 Impact factor: 19.112
Authors: Kristi Reynolds; Sharon H Saydah; Scott Isom; Jasmin Divers; Jean M Lawrence; Dana Dabelea; Elizabeth J Mayer-Davis; Giuseppina Imperatore; Ronny A Bell; Richard F Hamman Journal: J Diabetes Complications Date: 2018-04-04 Impact factor: 3.219
Authors: Joseph E O'Reilly; Luke A K Blackbourn; Thomas M Caparrotta; Anita Jeyam; Brian Kennon; Graham P Leese; Robert S Lindsay; Rory J McCrimmon; Stuart J McGurnaghan; Paul M McKeigue; John A McKnight; John R Petrie; Sam Philip; Naveed Sattar; Sarah H Wild; Helen M Colhoun Journal: Diabetologia Date: 2020-05-26 Impact factor: 10.122