Literature DB >> 28545957

Irradiation in a flash: Unique sparing of memory in mice after whole brain irradiation with dose rates above 100Gy/s.

Pierre Montay-Gruel1, Kristoffer Petersson2, Maud Jaccard2, Gaël Boivin3, Jean-François Germond2, Benoit Petit3, Raphaël Doenlen4, Vincent Favaudon5, François Bochud2, Claude Bailat2, Jean Bourhis3, Marie-Catherine Vozenin6.   

Abstract

This study shows for the first time that normal brain tissue toxicities after WBI can be reduced with increased dose rate. Spatial memory is preserved after WBI with mean dose rates above 100Gy/s, whereas 10Gy WBI at a conventional radiotherapy dose rate (0.1Gy/s) totally impairs spatial memory.
Copyright © 2017 Elsevier B.V. All rights reserved.

Entities:  

Keywords:  Cognition’s preservation; Flash-RT; Whole brain irradiation

Mesh：

Year:  2017        PMID： 28545957     DOI： 10.1016/j.radonc.2017.05.003

Source DB:  PubMed          Journal:  Radiother Oncol        ISSN： 0167-8140            Impact factor:   6.280


  82 in total

1.  An ionizing radiation acoustic imaging (iRAI) technique for real-time dosimetric measurements for FLASH radiotherapy.

Authors:  Ibrahim Oraiqat; Wei Zhang; Dale Litzenberg; Kwok Lam; Noora Ba Sunbul; Jean Moran; Kyle Cuneo; Paul Carson; Xueding Wang; Issam El Naqa
Journal:  Med Phys       Date:  2020-08-16       Impact factor: 4.071

2.  Long-term neurocognitive benefits of FLASH radiotherapy driven by reduced reactive oxygen species.

Authors:  Pierre Montay-Gruel; Munjal M Acharya; Kristoffer Petersson; Leila Alikhani; Chakradhar Yakkala; Barrett D Allen; Jonathan Ollivier; Benoit Petit; Patrik Gonçalves Jorge; Amber R Syage; Thuan A Nguyen; Al Anoud D Baddour; Celine Lu; Paramvir Singh; Raphael Moeckli; François Bochud; Jean-François Germond; Pascal Froidevaux; Claude Bailat; Jean Bourhis; Marie-Catherine Vozenin; Charles L Limoli
Journal:  Proc Natl Acad Sci U S A       Date:  2019-05-16       Impact factor: 11.205

Review 3.  Spatially fractionated proton minibeams.

Authors:  Juergen Meyer; John Eley; Thomas E Schmid; Stephanie E Combs; Remi Dendale; Yolanda Prezado
Journal:  Br J Radiol       Date:  2018-11-07       Impact factor: 3.039

4.  Design, Implementation, and in Vivo Validation of a Novel Proton FLASH Radiation Therapy System.

Authors:  Eric S Diffenderfer; Ioannis I Verginadis; Michele M Kim; Khayrullo Shoniyozov; Anastasia Velalopoulou; Denisa Goia; Mary Putt; Sarah Hagan; Stephen Avery; Kevin Teo; Wei Zou; Alexander Lin; Samuel Swisher-McClure; Cameron Koch; Ann R Kennedy; Andy Minn; Amit Maity; Theresa M Busch; Lei Dong; Costas Koumenis; James Metz; Keith A Cengel
Journal:  Int J Radiat Oncol Biol Phys       Date:  2020-02-01       Impact factor: 7.038

5.  Faster and safer? FLASH ultra-high dose rate in radiotherapy.

Authors:  Marco Durante; Elke Bräuer-Krisch; Mark Hill
Journal:  Br J Radiol       Date:  2017-12-15       Impact factor: 3.039

Review 6.  Expanding the therapeutic index of radiation therapy by normal tissue protection.

Authors:  Pierre Montay-Gruel; Lydia Meziani; Chakradhar Yakkala; Marie-Catherine Vozenin
Journal:  Br J Radiol       Date:  2018-07-02       Impact factor: 3.039

Review 7.  Proton beam therapy: perspectives on the National Health Service England clinical service and research programme.

Authors:  Neil G Burnet; Ranald I Mackay; Ed Smith; Amy L Chadwick; Gillian A Whitfield; David J Thomson; Matthew Lowe; Norman F Kirkby; Adrian M Crellin; Karen J Kirkby
Journal:  Br J Radiol       Date:  2020-01-14       Impact factor: 3.039

8.  Ultra-high dose rate effect on circulating immune cells: A potential mechanism for FLASH effect?

Authors:  Jian-Yue Jin; Anxin Gu; Weili Wang; Nancy L Oleinick; Mitchell Machtay; Feng-Ming Spring Kong
Journal:  Radiother Oncol       Date:  2020-05-06       Impact factor: 6.280

9.  Maintenance of Tight Junction Integrity in the Absence of Vascular Dilation in the Brain of Mice Exposed to Ultra-High-Dose-Rate FLASH Irradiation.

Authors:  Barrett D Allen; Munjal M Acharya; Pierre Montay-Gruel; Patrik Goncalves Jorge; Claude Bailat; Benoît Petit; Marie-Catherine Vozenin; Charles Limoli
Journal:  Radiat Res       Date:  2020-12-01       Impact factor: 2.841

Review 10.  Organoids as Complex In Vitro Models for Studying Radiation-Induced Cell Recruitment.

Authors:  Benjamin C Hacker; Marjan Rafat
Journal:  Cell Mol Bioeng       Date:  2020-06-15       Impact factor: 2.321
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