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Literature DB >> 28543919

"Heat shock protein 70 in pancreatic diseases: Friend or foe".

Bhuwan Giri¹, Vrishketan Sethi¹, Shrey Modi¹, Bharti Garg¹, Sulagna Banerjee¹, Ashok Saluja¹, Vikas Dudeja¹.

Abstract

The heat shock response in pancreatitis that is activated via HSP70 protects acinar cells through multiple simultaneous mechanisms. It inhibits trypsinogen activation and modulates NF-κB signaling to limit acinar cell injury. On the other hand, HSP70 is overexpressed in pancreatic cancer and is hijacked by the cellular machinery to inhibit apoptosis. Inhibition of HSP70 in pancreatic cancer by a novel compound, Minnelide, has shown considerable clinical promise.

Entities: CellLine Chemical Disease Gene Species

Keywords: HSP70; calcium; lysosomes; minnelide; pancreatic cancer; pancreatitis; triptolide

Mesh：

Substances：

Year: 2017 PMID： 28543919 PMCID： PMC5714583 DOI： 10.1002/jso.24653

Source DB: PubMed Journal: J Surg Oncol ISSN： 0022-4790 Impact factor: 3.454

80 in total

1. Heat-shock protein 70 inhibits apoptosis by preventing recruitment of procaspase-9 to the Apaf-1 apoptosome.

Authors: H M Beere; B B Wolf; K Cain; D D Mosser; A Mahboubi; T Kuwana; P Tailor; R I Morimoto; G M Cohen; D R Green
Journal: Nat Cell Biol Date: 2000-08 Impact factor: 28.824

Review 2. Stress (heat shock) proteins: molecular chaperones in cardiovascular biology and disease.

Authors: I J Benjamin; D R McMillan
Journal: Circ Res Date: 1998-07-27 Impact factor: 17.367

Review 3. Why does pancreatic overstimulation cause pancreatitis?

Authors: Ashok K Saluja; Markus M Lerch; Phoebe A Phillips; Vikas Dudeja
Journal: Annu Rev Physiol Date: 2007 Impact factor: 19.318

4. Hyperthermia induces heat shock protein expression and protection against cerulein-induced pancreatitis in rats.

Authors: A C Wagner; H Weber; L Jonas; H Nizze; M Strowski; F Fiedler; H Printz; H Steffen; B Göke
Journal: Gastroenterology Date: 1996-11 Impact factor: 22.682

Review 5. Peptide-binding heat shock proteins in the endoplasmic reticulum: role in immune response to cancer and in antigen presentation.

Authors: P K Srivastava
Journal: Adv Cancer Res Date: 1993 Impact factor: 6.242

6. How cells respond to stress.

Authors: W J Welch
Journal: Sci Am Date: 1993-05 Impact factor: 2.142

7. Impaired Synthesis of Stromal Components in Response to Minnelide Improves Vascular Function, Drug Delivery, and Survival in Pancreatic Cancer.

Authors: Sulagna Banerjee; Shrey Modi; Olivia McGinn; Xianda Zhao; Vikas Dudeja; Sundaram Ramakrishnan; Ashok K Saluja
Journal: Clin Cancer Res Date: 2015-09-24 Impact factor: 12.531

8. Hyperthermia protects against light damage in the rat retina.

Authors: M F Barbe; M Tytell; D J Gower; W J Welch
Journal: Science Date: 1988-09-30 Impact factor: 47.728

9. Sodium arsenite induces heat shock protein 70 expression and protects against secretagogue-induced trypsinogen and NF-kappaB activation.

Authors: Lakshmi Bhagat; Vijay P Singh; Rajinder K Dawra; Ashok K Saluja
Journal: J Cell Physiol Date: 2008-04 Impact factor: 6.384

10. Triptolide activates unfolded protein response leading to chronic ER stress in pancreatic cancer cells.

Authors: Nameeta Mujumdar; Sulagna Banerjee; Zhiyu Chen; Veena Sangwan; Rohit Chugh; Vikas Dudeja; Masato Yamamoto; Selwyn M Vickers; Ashok K Saluja
Journal: Am J Physiol Gastrointest Liver Physiol Date: 2014-04-03 Impact factor: 4.052

15 in total

Review 1. Pancreatic Cancer: Recent Progress of Drugs in Clinical Trials.

Authors: Zhiyi Zhang; Jie Song; Cao Xie; Jun Pan; Weiyue Lu; Min Liu
Journal: AAPS J Date: 2021-02-12 Impact factor: 4.009

2. Enhancing or inhibiting apoptosis? The effects of ucMSC-Ex in the treatment of different degrees of traumatic pancreatitis.

Authors: Zhao Zhirong; Han Li; He Yiqun; He Chunyang; Zhou Lichen; Tan Zhen; Wang Tao; Dai Ruiwu
Journal: Apoptosis Date: 2022-05-25 Impact factor: 5.561

3. In vivo antitumor effects of carboxymethyl chitosan-conjugated triptolide after oral administration.

Authors: Huahui Zeng; Xin Zhu; Qikang Tian; Yinyin Yan; Lan Zhang; Min Yan; Ruiqin Li; Xiaofang Li; Guoqiang Wang; Jinlian Ma; Yufang Su; Xiangbo Zhang; Linyu Ma; Zhenqiang Zhang; Xiangxiang Wu
Journal: Drug Deliv Date: 2020-12 Impact factor: 6.419

4. Increased expression of heat shock protein (HSP) 10 and HSP70 correlates with poor prognosis of nasopharyngeal carcinoma.

Authors: Juan Feng; Yuting Zhan; Yuting Zhang; Hongmei Zheng; Weiyuan Wang; Songqing Fan
Journal: Cancer Manag Res Date: 2019-09-06 Impact factor: 3.989

5. Triptolide targets super-enhancer networks in pancreatic cancer cells and cancer-associated fibroblasts.

Authors: Pawan Noel; Shaimaa Hussein; Serina Ng; Corina E Antal; Wei Lin; Emily Rodela; Priscilla Delgado; Sanna Naveed; Michael Downes; Yin Lin; Ronald M Evans; Daniel D Von Hoff; Haiyong Han
Journal: Oncogenesis Date: 2020-11-09 Impact factor: 7.485