Literature DB >> 9686751

Stress (heat shock) proteins: molecular chaperones in cardiovascular biology and disease.

I J Benjamin1, D R McMillan.   

Abstract

How a cell responds to stress is a central problem in cardiovascular biology. Diverse physiological stresses (eg, heat, hemodynamics, mutant proteins, and oxidative injury) produce multiple changes in a cell that ultimately affect protein structures and function. Cells from different phyla initiate a cascade of events that engage essential proteins, the molecular chaperones, in decisions to repair or degrade damaged proteins as a defense strategy to ensure survival. Accumulative evidence indicates that molecular chaperones such as the heat shock family of stress proteins (HSPs) actively participate in an array of cellular processes, including cytoprotection. The versatility of the ubiquitous HSP family is further enhanced by stress-inducible regulatory networks, both at the transcriptional and posttranscriptional levels. In the present review, we discuss the regulation and function of HSP chaperones and their clinical significance in conditions such as cardiac hypertrophy, vascular wall injury, cardiac surgery, ischemic preconditioning, aging, and, conceivably, mutations in genes encoding contractile proteins and ion channels.

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Year:  1998        PMID: 9686751     DOI: 10.1161/01.res.83.2.117

Source DB:  PubMed          Journal:  Circ Res        ISSN: 0009-7330            Impact factor:   17.367


  178 in total

Review 1.  Postmitochondrial regulation of apoptosis during heart failure.

Authors:  J C Reed; G Paternostro
Journal:  Proc Natl Acad Sci U S A       Date:  1999-07-06       Impact factor: 11.205

2.  Dynamics of haem oxygenase-1 expression and bilirubin production in cellular protection against oxidative stress.

Authors:  J E Clark; R Foresti; C J Green; R Motterlini
Journal:  Biochem J       Date:  2000-06-15       Impact factor: 3.857

Review 3.  Protective responses in the ischemic myocardium.

Authors:  R S Williams; I J Benjamin
Journal:  J Clin Invest       Date:  2000-10       Impact factor: 14.808

4.  The role of heat shock protein 27 in bronchiolitis obliterans syndrome after lung transplantation.

Authors:  Karen L Wood; David R Nunley; Susan Moffatt-Bruce; Amy Pope-Harman; Qin Huang; Eric N Shamo; Gary S Phillips; Chris Baran; Sanjay Batra; Clay B Marsh; Andrea I Doseff
Journal:  J Heart Lung Transplant       Date:  2010-04-24       Impact factor: 10.247

5.  Spectroscopic and thermodynamic properties of recombinant heat shock protein A6 from Camelus dromedarius.

Authors:  Ajamaluddin Malik; Abuzar Haroon; Haseeb Jagirdar; Abdulrahman M Alsenaidy; Mohamed Elrobh; Wajahatullah Khan; Mohammed S Alanazi; Mohammad D Bazzi
Journal:  Eur Biophys J       Date:  2014-11-14       Impact factor: 1.733

6.  The possibility of correction of the lipid profile of blood by superweak electromagnetic fields.

Authors:  B I Islamov; Yu V Gotovsky; E E Meizerov; L M Chailakhyan
Journal:  Dokl Biol Sci       Date:  2004 May-Jun

7.  Alpha-lipoic acid preserves the structural and functional integrity of red blood cells by adjusting the redox disturbance and decreasing O-GlcNAc modifications of antioxidant enzymes and heat shock proteins in diabetic rats.

Authors:  Mihailović Mirjana; Arambašić Jelena; Uskoković Aleksandra; Dinić Svetlana; Grdović Nevena; Marković Jelena; Poznanović Goran; Vidaković Melita
Journal:  Eur J Nutr       Date:  2011-11-18       Impact factor: 5.614

Review 8.  Molecular chaperones and heat shock proteins in atherosclerosis.

Authors:  Qingbo Xu; Bernhard Metzler; Marjan Jahangiri; Kaushik Mandal
Journal:  Am J Physiol Heart Circ Physiol       Date:  2011-11-04       Impact factor: 4.733

Review 9.  Stress-response proteins in cardiovascular disease.

Authors:  X Xiao; I J Benjamin
Journal:  Am J Hum Genet       Date:  1999-03       Impact factor: 11.025

10.  NF-kappaB driven cardioprotective gene programs; Hsp70.3 and cardioprotection after late ischemic preconditioning.

Authors:  Michael Tranter; Xiaoping Ren; Tiffany Forde; Michael E Wilhide; Jing Chen; Maureen A Sartor; Mario Medvedovic; W Keith Jones
Journal:  J Mol Cell Cardiol       Date:  2010-07-16       Impact factor: 5.000

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