Literature DB >> 33580411

Pancreatic Cancer: Recent Progress of Drugs in Clinical Trials.

Zhiyi Zhang1, Jie Song1, Cao Xie1, Jun Pan1, Weiyue Lu1, Min Liu2.   

Abstract

Pancreatic cancer is a highly malignant tumor and one of the primary causes of cancer-related death. Because pancreatic cancer is difficult to diagnose in the early course of the disease, most patients present with advanced lesions at the time of diagnosis, and only 20% of patients are eligible for surgery. Consequently, drug treatment has become extremely important. At present, the main treatment regimens for pancreatic cancer are gemcitabine and the FORFIRINOX and MPACT regimens. However, none of these regimens substantially improves the prognosis of patients with pancreatic cancer. Extensive efforts have been dedicated to the study of pancreatic cancer in recent years. With the development and clinical application of biological targeted drugs, the biological targeted treatment of tumors has been widely accepted. Therefore, this article used relevant clinical trial data to summarize the research progress of traditional chemotherapy drugs and biological targeted drugs for the treatment of pancreatic cancer.

Entities:  

Keywords:  angiogenesis inhibitors; anti-metabolite drugs; biological targeted drugs; chemotherapy drugs; kinase inhibitors

Year:  2021        PMID: 33580411     DOI: 10.1208/s12248-021-00556-2

Source DB:  PubMed          Journal:  AAPS J        ISSN: 1550-7416            Impact factor:   4.009


  82 in total

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Authors:  Sophie Gourgou-Bourgade; Caroline Bascoul-Mollevi; Françoise Desseigne; Marc Ychou; Olivier Bouché; Rosine Guimbaud; Yves Bécouarn; Antoine Adenis; Jean-Luc Raoul; Valérie Boige; Jocelyne Bérille; Thierry Conroy
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  3 in total

1.  The exploration of quantitative intra-tumoral metabolic heterogeneity in dual-time 18F-FDG PET/CT of pancreatic cancer.

Authors:  Guorong Jia; Jian Zhang; Rou Li; Jianhua Yan; Changjing Zuo
Journal:  Abdom Radiol (NY)       Date:  2021-04-18

2.  Imaging PARP with [18F]rucaparib in pancreatic cancer models.

Authors:  Chung Ying Chan; Zijun Chen; Gianluca Destro; Mathew Veal; Doreen Lau; Edward O'Neill; Gemma Dias; Michael Mosley; Veerle Kersemans; Florian Guibbal; Véronique Gouverneur; Bart Cornelissen
Journal:  Eur J Nucl Med Mol Imaging       Date:  2022-05-26       Impact factor: 10.057

Review 3.  Role of hypoxia in the tumor microenvironment and targeted therapy.

Authors:  Gaoqi Chen; Kaiwen Wu; Hao Li; Demeng Xia; Tianlin He
Journal:  Front Oncol       Date:  2022-09-23       Impact factor: 5.738

  3 in total

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