Literature DB >> 28530834

A Facile Radiolabeling of [18F]FDPA via Spirocyclic Iodonium Ylides: Preliminary PET Imaging Studies in Preclinical Models of Neuroinflammation.

Lu Wang1, Ran Cheng1,2, Masayuki Fujinaga3, Jian Yang4, Yiding Zhang3, Akiko Hatori3, Katsushi Kumata3, Jing Yang4, Neil Vasdev1, Yunfei Du2, Chongzhao Ran4, Ming-Rong Zhang3, Steven H Liang1.   

Abstract

A suitable TSPO PET ligand may visualize and quantify neuroinflammation in a living brain. Herein we report a 18F-ligand, [18F]2 ([18F]FDPA), is radiolabeled in high yield and high specific activity based on our spirocyclic iodonium ylide (SCIDY) strategy. [18F]2 demonstrated saturable specific binding to TSPO, substantially elevated brain uptake, and slow washout of bound PET signal in the preclinical models of brain neuroinflammation (cerebral ischemia and Alzheimer's disease).

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Year:  2017        PMID： 28530834      PMCID： PMC5576052          DOI： 10.1021/acs.jmedchem.7b00432

Source DB:  PubMed          Journal:  J Med Chem        ISSN： 0022-2623            Impact factor:   7.446


  35 in total

Review 1.  Imaging of microglia activation in stroke.

Authors:  Alexander Thiel; Wolf-Dieter Heiss
Journal:  Stroke       Date:  2010-12-16       Impact factor: 7.914

2.  Synthesis of (18) F-Difluoromethylarenes from Aryl (Pseudo) Halides.

Authors:  Hang Shi; Augustin Braun; Lu Wang; Steven H Liang; Neil Vasdev; Tobias Ritter
Journal:  Angew Chem Int Ed Engl       Date:  2016-08-05       Impact factor: 15.336

3.  Characterization of a novel acetamidobenzoxazolone-based PET ligand for translocator protein (18 kDa) imaging of neuroinflammation in the brain.

Authors:  Anjani K Tiwari; Joji Yui; Masayuki Fujinaga; Katsushi Kumata; Yoko Shimoda; Tomoteru Yamasaki; Lin Xie; Akiko Hatori; Jun Maeda; Nobuki Nengaki; Ming-Rong Zhang
Journal:  J Neurochem       Date:  2014-02-24       Impact factor: 5.372

Review 4.  Translocator protein (18 kDa) (TSPO) as a therapeutic target for neurological and psychiatric disorders.

Authors:  Rainer Rupprecht; Vassilios Papadopoulos; Gerhard Rammes; Thomas C Baghai; Jinjiang Fan; Nagaraju Akula; Ghislaine Groyer; David Adams; Michael Schumacher
Journal:  Nat Rev Drug Discov       Date:  2010-12       Impact factor: 84.694

5.  Visualization of early infarction in rat brain after ischemia using a translocator protein (18 kDa) PET ligand [11C]DAC with ultra-high specific activity.

Authors:  Joji Yui; Akiko Hatori; Kazunori Kawamura; Kazuhiko Yanamoto; Tomoteru Yamasaki; Masanao Ogawa; Yuichiro Yoshida; Katsushi Kumata; Masayuki Fujinaga; Nobuki Nengaki; Toshimitsu Fukumura; Kazutoshi Suzuki; Ming-Rong Zhang
Journal:  Neuroimage       Date:  2010-08-10       Impact factor: 6.556

6.  Metabolism and quantification of [(18)F]DPA-714, a new TSPO positron emission tomography radioligand.

Authors:  Marie-Anne Peyronneau; Wadad Saba; Sébastien Goutal; Annelaure Damont; Frédéric Dollé; Michael Kassiou; Michel Bottlaender; Héric Valette
Journal:  Drug Metab Dispos       Date:  2012-10-12       Impact factor: 3.922

Review 7.  The peripheral benzodiazepine receptor: a promising therapeutic drug target.

Authors:  Sylvaine Galiegue; Norbert Tinel; Pierre Casellas
Journal:  Curr Med Chem       Date:  2003-08       Impact factor: 4.530

Review 8.  Neuroinflammation in Alzheimer's disease.

Authors:  Michael T Heneka; Monica J Carson; Joseph El Khoury; Gary E Landreth; Frederic Brosseron; Douglas L Feinstein; Andreas H Jacobs; Tony Wyss-Coray; Javier Vitorica; Richard M Ransohoff; Karl Herrup; Sally A Frautschy; Bente Finsen; Guy C Brown; Alexei Verkhratsky; Koji Yamanaka; Jari Koistinaho; Eicke Latz; Annett Halle; Gabor C Petzold; Terrence Town; Dave Morgan; Mari L Shinohara; V Hugh Perry; Clive Holmes; Nicolas G Bazan; David J Brooks; Stéphane Hunot; Bertrand Joseph; Nikolaus Deigendesch; Olga Garaschuk; Erik Boddeke; Charles A Dinarello; John C Breitner; Greg M Cole; Douglas T Golenbock; Markus P Kummer
Journal:  Lancet Neurol       Date:  2015-04       Impact factor: 44.182

Review 9.  Visualising microglial activation in vivo.

Authors:  Richard B Banati
Journal:  Glia       Date:  2002-11       Impact factor: 8.073

10.  Radiosynthesis and Preclinical Evaluation of [18F]F-DPA, A Novel Pyrazolo[1,5a]pyrimidine Acetamide TSPO Radioligand, in Healthy Sprague Dawley Rats.

Authors:  Thomas Keller; Anna Krzyczmonik; Sarita Forsback; Francisco R López Picón; Anna K Kirjavainen; Jatta Takkinen; Johan Rajander; Fanny Cacheux; Annelaure Damont; Frédéric Dollé; Juha O Rinne; Merja Haaparanta-Solin; Olof Solin
Journal:  Mol Imaging Biol       Date:  2017-10       Impact factor: 3.488
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  16 in total

1.  Comparison of high and low molar activity TSPO tracer [18F]F-DPA in a mouse model of Alzheimer's disease.

Authors:  Thomas Keller; Francisco R López-Picón; Anna Krzyczmonik; Sarita Forsback; Jatta S Takkinen; Johan Rajander; Simo Teperi; Frédéric Dollé; Juha O Rinne; Merja Haaparanta-Solin; Olof Solin
Journal:  J Cereb Blood Flow Metab       Date:  2019-05-29       Impact factor: 6.200

2.  PET Imaging of the P2X7 Ion Channel with a Novel Tracer [18F]JNJ-64413739 in a Rat Model of Neuroinflammation.

Authors:  Tamara Berdyyeva; Chunfang Xia; Natalie Taylor; Yingbo He; Gang Chen; Chaofeng Huang; Wei Zhang; Hartmuth Kolb; Michael Letavic; Anindya Bhattacharya; Anna Katrin Szardenings
Journal:  Mol Imaging Biol       Date:  2019-10       Impact factor: 3.488

Review 3.  Chemistry for Positron Emission Tomography: Recent Advances in 11 C-, 18 F-, 13 N-, and 15 O-Labeling Reactions.

Authors:  Xiaoyun Deng; Jian Rong; Lu Wang; Neil Vasdev; Lei Zhang; Lee Josephson; Steven H Liang
Journal:  Angew Chem Int Ed Engl       Date:  2019-01-14       Impact factor: 15.336

4.  A novel monoacylglycerol lipase-targeted 18F-labeled probe for positron emission tomography imaging of brown adipose tissue in the energy network.

Authors:  Ran Cheng; Masayuki Fujinaga; Jing Yang; Jian Rong; Ahmed Haider; Daisuke Ogasawara; Richard S Van; Tuo Shao; Zhen Chen; Xiaofei Zhang; Erick R Calderon Leon; Yiding Zhang; Wakana Mori; Katsushi Kumata; Tomoteru Yamasaki; Lin Xie; Shaofa Sun; Lu Wang; Chongzhao Ran; Yihan Shao; Benjamin Cravatt; Lee Josephson; Ming-Rong Zhang; Steven H Liang
Journal:  Acta Pharmacol Sin       Date:  2022-05-05       Impact factor: 6.150

Review 5.  Novel PET Imaging of Inflammatory Targets and Cells for the Diagnosis and Monitoring of Giant Cell Arteritis and Polymyalgia Rheumatica.

Authors:  Kornelis S M van der Geest; Maria Sandovici; Pieter H Nienhuis; Riemer H J A Slart; Peter Heeringa; Elisabeth Brouwer; William F Jiemy
Journal:  Front Med (Lausanne)       Date:  2022-06-06

6.  In Vitro and in Vivo Evaluation of 11C-Labeled Azetidinecarboxylates for Imaging Monoacylglycerol Lipase by PET Imaging Studies.

Authors:  Ran Cheng; Wakana Mori; Longle Ma; Mireille Alhouayek; Akiko Hatori; Yiding Zhang; Daisuke Ogasawara; Gengyang Yuan; Zhen Chen; Xiaofei Zhang; Hang Shi; Tomoteru Yamasaki; Lin Xie; Katsushi Kumata; Masayuki Fujinaga; Yuji Nagai; Takafumi Minamimoto; Mona Svensson; Lu Wang; Yunfei Du; Mary Jo Ondrechen; Neil Vasdev; Benjamin F Cravatt; Christopher Fowler; Ming-Rong Zhang; Steven H Liang
Journal:  J Med Chem       Date:  2018-03-09       Impact factor: 7.446

7.  PET Imaging of Human Brown Adipose Tissue with the TSPO Tracer [11C]PBR28.

Authors:  Chongzhao Ran; Daniel S Albrecht; Miriam A Bredella; Jing Yang; Jian Yang; Steven H Liang; Aaron M Cypess; Marco L Loggia; Nazem Atassi; Anna Moore
Journal:  Mol Imaging Biol       Date:  2018-04       Impact factor: 3.488

8.  Synthesis-free PET imaging of brown adipose tissue and TSPO via combination of disulfiram and 64CuCl2.

Authors:  Jing Yang; Jian Yang; Lu Wang; Anna Moore; Steven H Liang; Chongzhao Ran
Journal:  Sci Rep       Date:  2017-08-15       Impact factor: 4.379

9.  TSPO-PET imaging using [18F]PBR06 is a potential translatable biomarker for treatment response in Huntington's disease: preclinical evidence with the p75NTR ligand LM11A-31.

Authors:  Danielle A Simmons; Michelle L James; Nadia P Belichenko; Sarah Semaan; Christina Condon; Jason Kuan; Adam J Shuhendler; Zheng Miao; Frederick T Chin; Frank M Longo
Journal:  Hum Mol Genet       Date:  2018-08-15       Impact factor: 6.150

10.  Synthesis and preliminary studies of 11C-labeled tetrahydro-1,7-naphthyridine-2-carboxamides for PET imaging of metabotropic glutamate receptor 2.

Authors:  Xiaofei Zhang; Yiding Zhang; Zhen Chen; Tuo Shao; Richard Van; Katsushi Kumata; Xiaoyun Deng; Hualong Fu; Tomoteru Yamasaki; Jian Rong; Kuan Hu; Akiko Hatori; Lin Xie; Qingzhen Yu; Weijian Ye; Hao Xu; Douglas J Sheffler; Nicholas D P Cosford; Yihan Shao; Pingping Tang; Lu Wang; Ming-Rong Zhang; Steven H Liang
Journal:  Theranostics       Date:  2020-09-14       Impact factor: 11.556
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