Chongzhao Ran1, Daniel S Albrecht2,3, Miriam A Bredella4, Jing Yang5, Jian Yang5, Steven H Liang6, Aaron M Cypess7, Marco L Loggia2, Nazem Atassi8, Anna Moore5. 1. Molecular Imaging Laboratory, Athinoula. A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital and Harvard Medical School, Boston, MA, 02129, USA. cran@nmr.mgh.harvard.edu. 2. Athinoula. A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital and Harvard Medical School, Boston, MA, 02129, USA. 3. Division of Nuclear Medicine and Molecular Imaging & Gordon Center for Medical Imaging, Massachusetts General Hospital and Harvard Medical School, Boston, MA, 02114, USA. 4. Division of Musculoskeletal Imaging and Intervention, Massachusetts General Hospital and Harvard Medical School, Boston, MA, 02114, USA. 5. Molecular Imaging Laboratory, Athinoula. A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital and Harvard Medical School, Boston, MA, 02129, USA. 6. Division of Nuclear Medicine and Molecular Imaging, Massachusetts General Hospital and Harvard Medical School, Boston, MA, 02114, USA. 7. Diabetes, Endocrinology, and Obesity Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD, 20892, USA. 8. Neurological Clinical Research Institute (NCRI), Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, 02114, USA.
Abstract
PURPOSE: Brown adipose tissue (BAT) in adult humans has been recently rediscovered and intensively investigated as a new potential therapeutic target for obesity and type 2 diabetes (T2D). However, reliable assessment of BAT mass in vivo represents a considerable challenge. The purpose of this investigation is to demonstrate for the first time that human BAT depots can be imaged with a translocator protein (TSPO)-specific positron emission tomography (PET) tracer [11C]PBR28 under thermoneutral conditions. PROCEDURES: In this retrospective analysis, we analyzed the images of three healthy volunteers who underwent PET/magnetic resonance (MR) imaging after injection of 14 m Ci of [11C]PBR28 at room temperature. Thirty-minute static PET images were reconstructed from the data obtained 60-90 min after the injection of the tracer. RESULTS: [11C]PBR28 uptake in the neck/supraclavicular regions was identified, which was parallel to the known distribution pattern of human BAT depots. These areas co-localized with the areas of hyperintensity and corresponded to fat on T1-weighted MR images. Standardized uptake value (SUV) was used to quantify [11C]PBR28 signal in BAT depots. The average (± SD) SUV(mean) and SUVmax for BAT depots was 2.13 (± 0.33) and 3.19 (± 0.34), respectively, while the average SUV(mean) for muscle and subcutaneous adipose tissue was 0.79 (± 0.1) and 0.18 (± 0.04), respectively. CONCLUSIONS: In this brief article, we provide the first evidence suggesting that [11C]PBR28, a widely available TSPO-specific PET tracer, can be used for imaging human BAT mass under thermoneutral conditions.
PURPOSE: Brown adipose tissue (BAT) in adult humans has been recently rediscovered and intensively investigated as a new potential therapeutic target for obesity and type 2 diabetes (T2D). However, reliable assessment of BAT mass in vivo represents a considerable challenge. The purpose of this investigation is to demonstrate for the first time that human BAT depots can be imaged with a translocator protein (TSPO)-specific positron emission tomography (PET) tracer [11C]PBR28 under thermoneutral conditions. PROCEDURES: In this retrospective analysis, we analyzed the images of three healthy volunteers who underwent PET/magnetic resonance (MR) imaging after injection of 14 m Ci of [11C]PBR28 at room temperature. Thirty-minute static PET images were reconstructed from the data obtained 60-90 min after the injection of the tracer. RESULTS:[11C]PBR28 uptake in the neck/supraclavicular regions was identified, which was parallel to the known distribution pattern of human BAT depots. These areas co-localized with the areas of hyperintensity and corresponded to fat on T1-weighted MR images. Standardized uptake value (SUV) was used to quantify [11C]PBR28 signal in BAT depots. The average (± SD) SUV(mean) and SUVmax for BAT depots was 2.13 (± 0.33) and 3.19 (± 0.34), respectively, while the average SUV(mean) for muscle and subcutaneous adipose tissue was 0.79 (± 0.1) and 0.18 (± 0.04), respectively. CONCLUSIONS: In this brief article, we provide the first evidence suggesting that [11C]PBR28, a widely available TSPO-specific PET tracer, can be used for imaging human BAT mass under thermoneutral conditions.
Authors: Rajesh R Rao; Jonathan Z Long; James P White; Katrin J Svensson; Jesse Lou; Isha Lokurkar; Mark P Jedrychowski; Jorge L Ruas; Christiane D Wrann; James C Lo; Donny M Camera; Jenn Lachey; Steven Gygi; Jasbir Seehra; John A Hawley; Bruce M Spiegelman Journal: Cell Date: 2014-06-05 Impact factor: 41.582
Authors: Rosa Tamara Branca; Ting He; Le Zhang; Carlos S Floyd; Matthew Freeman; Christian White; Alex Burant Journal: Proc Natl Acad Sci U S A Date: 2014-12-01 Impact factor: 11.205
Authors: Alexander Bartelt; Oliver T Bruns; Rudolph Reimer; Heinz Hohenberg; Harald Ittrich; Kersten Peldschus; Michael G Kaul; Ulrich I Tromsdorf; Horst Weller; Christian Waurisch; Alexander Eychmüller; Philip L S M Gordts; Franz Rinninger; Karoline Bruegelmann; Barbara Freund; Peter Nielsen; Martin Merkel; Joerg Heeren Journal: Nat Med Date: 2011-01-23 Impact factor: 53.440
Authors: Wouter D van Marken Lichtenbelt; Joost W Vanhommerig; Nanda M Smulders; Jamie M A F L Drossaerts; Gerrit J Kemerink; Nicole D Bouvy; Patrick Schrauwen; G J Jaap Teule Journal: N Engl J Med Date: 2009-04-09 Impact factor: 91.245
Authors: Kornelis S M van der Geest; Maria Sandovici; Pieter H Nienhuis; Riemer H J A Slart; Peter Heeringa; Elisabeth Brouwer; William F Jiemy Journal: Front Med (Lausanne) Date: 2022-06-06
Authors: S V Hartimath; S Khanapur; R Boominathan; L Jiang; P Cheng; F F Yong; P W Tan; E G Robins; J L Goggi Journal: Mol Metab Date: 2019-05-06 Impact factor: 7.422
Authors: Swati Shah; Sanhita Sinharay; Reema Patel; Jeffrey Solomon; Ji Hyun Lee; William Schreiber-Stainthorp; Falguni Basuli; Xiang Zhang; Katie R Hagen; Rebecca Reeder; Paul Wakim; Louis M Huzella; Dragan Maric; Reed F Johnson; Dima A Hammoud Journal: Proc Natl Acad Sci U S A Date: 2022-04-06 Impact factor: 12.779