Literature DB >> 28522321

Why do we continue to overtreat stage Ia carcinoma of the cervix?

Tommy Buchanan1, Jennifer Young Pierce2, Whitney Graybill2, Matthew Kohler2, William Creasman2.   

Abstract

The current recommended treatment for stage Ia2 cervical cancer is a radical or modified radical hysterectomy. Although in the United States the incidence of cervical cancer is low and declining, almost 50% of the >4000 new cases will present in early stages. An estimated 2200 women each year will undergo radical hysterectomy and many will have both early- and late-onset complications. The purpose of this review is to examine if there is still a role for radical hysterectomy in the proper treatment of stage Ia2 cervical cancer given most recent data. Sufficient histological evidence suggests that although parametrial involvement and lymph node metastases can increase the risk for recurrence, they are relatively uncommon at early stages. Worldwide data that challenge radical hysterectomy as standard of care have shown that conservative management of stage Ia2 cervical cancer results in similar survival and recurrence rates. It is the recommendation based on all reviewed data that radical hysterectomy should no longer be considered standard of care in all cases of stage Ia2 cervical cancer.
Copyright © 2017 Elsevier Inc. All rights reserved.

Entities:  

Keywords:  cervical cancer; radical hysterectomy; staging; treatment

Mesh:

Year:  2017        PMID: 28522321     DOI: 10.1016/j.ajog.2017.05.020

Source DB:  PubMed          Journal:  Am J Obstet Gynecol        ISSN: 0002-9378            Impact factor:   8.661


  5 in total

1.  Clinical Epidemiology of Microinvasive Cervical Carcinoma in an Italian Population Targeted by a Screening Programme.

Authors:  Lauro Bucchi; Silvano Costa; Silvia Mancini; Flavia Baldacchini; Orietta Giuliani; Alessandra Ravaioli; Rosa Vattiato; Federica Zamagni; Paolo Giorgi Rossi; Cinzia Campari; Debora Canuti; Priscilla Sassoli de Bianchi; Stefano Ferretti; Fabio Falcini
Journal:  Cancers (Basel)       Date:  2022-04-22       Impact factor: 6.575

Review 2.  The role of lymph nodes in cervical cancer: incidence and identification of lymph node metastases-a literature review.

Authors:  Ester P Olthof; Maaike A van der Aa; Judit A Adam; Lukas J A Stalpers; Hans H B Wenzel; Jacobus van der Velden; Constantijne H Mom
Journal:  Int J Clin Oncol       Date:  2021-07-09       Impact factor: 3.402

3.  Does the New FIGO 2018 Staging System Allow Better Prognostic Differentiation in Early Stage Cervical Cancer? A Dutch Nationwide Cohort Study.

Authors:  Mieke L G Ten Eikelder; Floor Hinten; Anke Smits; Maaike A Van der Aa; Ruud L M Bekkers; Joanna IntHout; Hans H B Wenzel; Petra L M Zusterzeel
Journal:  Cancers (Basel)       Date:  2022-06-27       Impact factor: 6.575

4.  Conservative treatment of microinvasive squamous cell carcinoma of the cervix stage IA1: Defining conization height to an optimal oncological outcome.

Authors:  Caio A Hartman; Joana F Bragança; Maria Salete C Gurgel; Luiz C Zeferino; Liliana A L A Andrade; Julio C Teixeira
Journal:  PLoS One       Date:  2021-07-20       Impact factor: 3.240

5.  Prognostic significance of solitary lymph node metastasis in patients with stages IA2 to IIA cervical carcinoma.

Authors:  Yi-Fang Dai; Mu Xu; Li-Ying Zhong; Xiao-Yan Xie; Zhao-Dong Liu; Ming-Xing Yan; Huan Yi; Dan-Mei Lin
Journal:  J Int Med Res       Date:  2018-07-01       Impact factor: 1.671

  5 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.