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Literature DB >> 28510227

Kinesin Motor Enzymology: Chemistry, Structure, and Physics of Nanoscale Molecular Machines.

Abstract

Molecular motors are enzymes that convert chemical potential energy into controlled kinetic energy for mechanical work inside cells. Understanding the biophysics of these motors is essential for appreciating life as well as apprehending diseases that arise from motor malfunction. This review focuses on kinesin motor enzymology with special emphasis on the literature that reports the chemistry, structure and physics of several different kinesin superfamily members.

Keywords: Chemical models; Enzymes; Kinesin motor enzymology; Kinesin superfamily; Molecular motors

Year: 2015 PMID： 28510227 PMCID： PMC5418420 DOI： 10.1007/s12551-014-0150-6

Source DB: PubMed Journal: Biophys Rev ISSN： 1867-2450

279 in total

1. Structure of a fast kinesin: implications for ATPase mechanism and interactions with microtubules.

Authors: Y H Song; A Marx; J Müller; G Woehlke; M Schliwa; A Krebs; A Hoenger; E Mandelkow
Journal: EMBO J Date: 2001-11-15 Impact factor: 11.598

2. Three myosin V structures delineate essential features of chemo-mechanical transduction.

Authors: Pierre-Damien Coureux; H Lee Sweeney; Anne Houdusse
Journal: EMBO J Date: 2004-10-28 Impact factor: 11.598

3. Kif18A uses a microtubule binding site in the tail for plus-end localization and spindle length regulation.

Authors: Lesley N Weaver; Stephanie C Ems-McClung; Jane R Stout; Chantal LeBlanc; Sidney L Shaw; Melissa K Gardner; Claire E Walczak
Journal: Curr Biol Date: 2011-09-01 Impact factor: 10.834

4. Kinesin Kar3Cik1 ATPase pathway for microtubule cross-linking.

Authors: Chun Ju Chen; Ivan Rayment; Susan P Gilbert
Journal: J Biol Chem Date: 2011-06-16 Impact factor: 5.157

5. Influence of the kinesin neck domain on dimerization and ATPase kinetics.

Authors: W Jiang; M F Stock; X Li; D D Hackney
Journal: J Biol Chem Date: 1997-03-21 Impact factor: 5.157

6. Effect of spastic paraplegia mutations in KIF5A kinesin on transport activity.

Authors: Bettina Ebbing; Klaudiusz Mann; Agata Starosta; Johann Jaud; Ludger Schöls; Rebecca Schüle; Günther Woehlke
Journal: Hum Mol Genet Date: 2008-01-18 Impact factor: 6.150

7. A kinesin motor in a force-producing conformation.

Authors: Elisabeth Heuston; C Eric Bronner; F Jon Kull; Sharyn A Endow
Journal: BMC Struct Biol Date: 2010-07-05

8. Kinesin tail domains and Mg2+ directly inhibit release of ADP from head domains in the absence of microtubules.

Authors: David D Hackney; Maryanne F Stock
Journal: Biochemistry Date: 2008-06-26 Impact factor: 3.162

9. Kinesin-8 from fission yeast: a heterodimeric, plus-end-directed motor that can couple microtubule depolymerization to cargo movement.

Authors: Paula M Grissom; Thomas Fiedler; Ekaterina L Grishchuk; Daniela Nicastro; Robert R West; J Richard McIntosh
Journal: Mol Biol Cell Date: 2008-11-26 Impact factor: 4.138

10. A non-motor microtubule binding site is essential for the high processivity and mitotic function of kinesin-8 Kif18A.

Authors: Monika I Mayr; Marko Storch; Jonathon Howard; Thomas U Mayer
Journal: PLoS One Date: 2011-11-10 Impact factor: 3.240

16 in total

1. Statistical properties of autonomous flows in 2D active nematics.

Authors: Linnea M Lemma; Stephen J DeCamp; Zhihong You; Luca Giomi; Zvonimir Dogic
Journal: Soft Matter Date: 2019-04-10 Impact factor: 3.679

2. Flexible microtubule anchoring modulates the bi-directional motility of the kinesin-5 Cin8.

Authors: Himanshu Pandey; Sudhir Kumar Singh; Mayan Sadan; Mary Popov; Meenakshi Singh; Geula Davidov; Sayaka Inagaki; Jawdat Al-Bassam; Raz Zarivach; Steven S Rosenfeld; Larisa Gheber
Journal: Cell Mol Life Sci Date: 2021-07-17 Impact factor: 9.261

Review 3. Bidirectional motility of kinesin-5 motor proteins: structural determinants, cumulative functions and physiological roles.

Authors: Sudhir Kumar Singh; Himanshu Pandey; Jawdat Al-Bassam; Larisa Gheber
Journal: Cell Mol Life Sci Date: 2018-02-03 Impact factor: 9.261

Kinesin Motor Enzymology: Chemistry, Structure, and Physics of Nanoscale Molecular Machines.

1. Structure of a fast kinesin: implications for ATPase mechanism and interactions with microtubules.

2. Three myosin V structures delineate essential features of chemo-mechanical transduction.

3. Kif18A uses a microtubule binding site in the tail for plus-end localization and spindle length regulation.

4. Kinesin Kar3Cik1 ATPase pathway for microtubule cross-linking.

5. Influence of the kinesin neck domain on dimerization and ATPase kinetics.

6. Effect of spastic paraplegia mutations in KIF5A kinesin on transport activity.

7. A kinesin motor in a force-producing conformation.

8. Kinesin tail domains and Mg2+ directly inhibit release of ADP from head domains in the absence of microtubules.

9. Kinesin-8 from fission yeast: a heterodimeric, plus-end-directed motor that can couple microtubule depolymerization to cargo movement.

10. A non-motor microtubule binding site is essential for the high processivity and mitotic function of kinesin-8 Kif18A.

1. Statistical properties of autonomous flows in 2D active nematics.

2. Flexible microtubule anchoring modulates the bi-directional motility of the kinesin-5 Cin8.

Review 3. Bidirectional motility of kinesin-5 motor proteins: structural determinants, cumulative functions and physiological roles.

4. Protein Diffusion on Charged Biopolymers: DNA versus Microtubule.

5. Kinesin motility is driven by subdomain dynamics.

6. Structural basis for power stroke vs. Brownian ratchet mechanisms of motor proteins.

7. Shaft Function of Kinesin-1's α4 Helix in the Processive Movement.

8. Comparison of explicit and mean-field models of cytoskeletal filaments with crosslinking motors.

9. Sequences in the stalk domain regulate auto-inhibition and ciliary tip localization of the immotile kinesin-4 KIF7.

Review 10. Mechanisms by Which Kinesin-5 Motors Perform Their Multiple Intracellular Functions.