Maxime Doiron1,2,3, Mélanie Langlois3,4, Nicolas Dupré3,4, Martine Simard1,2. 1. School of Psychology, Laval University, Quebec City, Canada. 2. Centre de Recherche de l'Institut Universitaire en Santé Mentale de Québec, Quebec City, Canada. 3. Faculty of Medicine, Laval University, Quebec City, Canada. 4. Department of Neurological Sciences, CHU de Québec (Enfant-Jésus), Quebec City, Canada.
Abstract
OBJECTIVES: Hypertension, dyslipidemia, diabetes, and obesity are well-established risk factors for cognitive impairment and dementia in older adults. In contrast, previous studies that have assessed the impact of vascular risk factors (VRFs) on cognition in Parkinson's disease (PD) have had methodological limitations and reported conflicting findings. We address this question in a large well-characterized cohort of de novo PD patients. METHODS: A total of 367 untreated and non-demented patients aged 50 years and older with early PD (H&Y = 1.0-2.0) underwent a comprehensive clinical and neuropsychological assessment at baseline and 24 months later. A series of linear mixed models were used to determine the effects of VRFs on cognition while controlling for patient and disease characteristics. The outcomes included norm-referenced Z-scores of global cognition, visuospatial skills, verbal episodic memory, semantic verbal fluency, attention, and working memory tests. RESULTS: A longer history of hypertension and a higher pulse pressure were significant predictors of lower Z-scores on immediate and delayed free recall, recognition, and verbal fluency tests. On average, every 10 mmHg increase in pulse pressure was associated with a 0.08 reduction on the cognitive Z-scores. The effects were independent of age, education, disease duration, motor impairment, medication, and depressive symptoms. Other VRFs were not associated with cognitive outcomes. CONCLUSIONS: Our results are consistent with previous studies suggesting that hypertension exerts a detrimental effect on memory and verbal fluency in early PD. Management of blood pressure and cardiovascular health may be important to reduce risk of cognitive decline in PD.
OBJECTIVES:Hypertension, dyslipidemia, diabetes, and obesity are well-established risk factors for cognitive impairment and dementia in older adults. In contrast, previous studies that have assessed the impact of vascular risk factors (VRFs) on cognition in Parkinson's disease (PD) have had methodological limitations and reported conflicting findings. We address this question in a large well-characterized cohort of de novo PDpatients. METHODS: A total of 367 untreated and non-demented patients aged 50 years and older with early PD (H&Y = 1.0-2.0) underwent a comprehensive clinical and neuropsychological assessment at baseline and 24 months later. A series of linear mixed models were used to determine the effects of VRFs on cognition while controlling for patient and disease characteristics. The outcomes included norm-referenced Z-scores of global cognition, visuospatial skills, verbal episodic memory, semantic verbal fluency, attention, and working memory tests. RESULTS: A longer history of hypertension and a higher pulse pressure were significant predictors of lower Z-scores on immediate and delayed free recall, recognition, and verbal fluency tests. On average, every 10 mmHg increase in pulse pressure was associated with a 0.08 reduction on the cognitive Z-scores. The effects were independent of age, education, disease duration, motor impairment, medication, and depressive symptoms. Other VRFs were not associated with cognitive outcomes. CONCLUSIONS: Our results are consistent with previous studies suggesting that hypertension exerts a detrimental effect on memory and verbal fluency in early PD. Management of blood pressure and cardiovascular health may be important to reduce risk of cognitive decline in PD.
Authors: L M Chahine; C Dos Santos; M Fullard; C Scordia; D Weintraub; G Erus; L Rosenthal; C Davatzikos; C T McMillan Journal: Eur J Neurol Date: 2018-10-28 Impact factor: 6.089
Authors: Brenna Cholerton; Catherine O Johnson; Brian Fish; Joseph F Quinn; Kathryn A Chung; Amie L Peterson-Hiller; Liana S Rosenthal; Ted M Dawson; Marilyn S Albert; Shu-Ching Hu; Ignacio F Mata; James B Leverenz; Kathleen L Poston; Thomas J Montine; Cyrus P Zabetian; Karen L Edwards Journal: Parkinsonism Relat Disord Date: 2018-02-09 Impact factor: 4.891
Authors: Ana Patrícia da Silva Souza; Waleska Maria Almeida Barros; José Maurício Lucas Silva; Mariluce Rodrigues Marques Silva; Ana Beatriz Januário Silva; Matheus Santos de Sousa Fernandes; Maria Eduarda Rodrigues Alves Dos Santos; Mayara Luclécia da Silva; Taciane Silva do Carmo; Roberta Karlize Pereira Silva; Karollainy Gomes da Silva; Sandra Lopes de Souza; Viviane de Oliveira Nogueira Souza Journal: Clinics (Sao Paulo) Date: 2021-12-13 Impact factor: 2.365
Authors: Ziv Gan-Or; Trisha Rao; Etienne Leveille; Clotilde Degroot; Sylvain Chouinard; Francesca Cicchetti; Alain Dagher; Samir Das; Alex Desautels; Janelle Drouin-Ouellet; Thomas Durcan; Jean-François Gagnon; Angela Genge; Jason Karamchandani; Anne-Louise Lafontaine; Sonia Lai Wing Sun; Mélanie Langlois; Martin Levesque; Calvin Melmed; Michel Panisset; Martin Parent; Jean-Baptiste Poline; Ronald B Postuma; Emmanuelle Pourcher; Guy A Rouleau; Madeleine Sharp; Oury Monchi; Nicolas Dupré; Edward A Fon Journal: J Parkinsons Dis Date: 2020 Impact factor: 5.568