Ece Bayram1, Sarah J Banks1, Guogen Shan2, Nikki Kaplan3, Jessica Z K Caldwell3. 1. Department of Neurosciences, University of California San Diego, La Jolla, CA, USA. 2. Department of Environmental and Occupational Health, University of Nevada Las Vegas, Las Vegas, NV, USA. 3. Lou Ruvo Center for Brain Health, Cleveland Clinic, Las Vegas, NV, USA.
Abstract
OBJECTIVE: To evaluate the sex differences in cognitive course over 4 years in Parkinson's disease (PD) patients with and without mild cognitive impairment (MCI) compared to controls. METHODS: Four-year longitudinal cognitive scores of 257 cognitively intact PD, 167 PD-MCI, and 140 controls from the Parkinson's Progression Markers Initiative were included. Longitudinal scores of men and women, and PD with and without MCI were compared. RESULTS: Women had better verbal memory, men had better visuospatial function. There was no interaction between sex, diagnostic group, and/or time (4-year follow-up period). CONCLUSIONS: Sex differences in cognitive course in de novo PD are similar to healthy aging. Cognitive decline rates in PD with and without MCI are similar for the first 4 years of PD.
OBJECTIVE: To evaluate the sex differences in cognitive course over 4 years in Parkinson's disease (PD) patients with and without mild cognitive impairment (MCI) compared to controls. METHODS: Four-year longitudinal cognitive scores of 257 cognitively intact PD, 167 PD-MCI, and 140 controls from the Parkinson's Progression Markers Initiative were included. Longitudinal scores of men and women, and PD with and without MCI were compared. RESULTS:Women had better verbal memory, men had better visuospatial function. There was no interaction between sex, diagnostic group, and/or time (4-year follow-up period). CONCLUSIONS: Sex differences in cognitive course in de novo PD are similar to healthy aging. Cognitive decline rates in PD with and without MCI are similar for the first 4 years of PD.
Entities:
Keywords:
Cognition; Decline; Longitudinal studies; Memory; Parkinson’s disease; Sex
Authors: Christopher G Goetz; Barbara C Tilley; Stephanie R Shaftman; Glenn T Stebbins; Stanley Fahn; Pablo Martinez-Martin; Werner Poewe; Cristina Sampaio; Matthew B Stern; Richard Dodel; Bruno Dubois; Robert Holloway; Joseph Jankovic; Jaime Kulisevsky; Anthony E Lang; Andrew Lees; Sue Leurgans; Peter A LeWitt; David Nyenhuis; C Warren Olanow; Olivier Rascol; Anette Schrag; Jeanne A Teresi; Jacobus J van Hilten; Nancy LaPelle Journal: Mov Disord Date: 2008-11-15 Impact factor: 10.338
Authors: Nor A Samat; Nor A Abdul Murad; Khairiyah Mohamad; Mohd R Abdul Razak; Norlinah Mohamed Ibrahim Journal: Front Neurosci Date: 2017-12-20 Impact factor: 4.677
Authors: Guogen Shan; Ece Bayram; Jessica Z K Caldwell; Justin B Miller; Jay J Shen; Shawn Gerstenberger Journal: Stat Biopharm Res Date: 2020-07-20 Impact factor: 1.452
Authors: Hind A Beydoun; Sharmin Hossain; Shuyan Huang; May A Beydoun; Brook T Alemu; Shaker M Eid; Alan B Zonderman Journal: Psychosom Med Date: 2021-06-01 Impact factor: 3.864