Literature DB >> 28496736

Altered Excitation-Contraction Coupling in Human Chronic Atrial Fibrillation.

Eleonora Grandi1, Antony J Workman2, Sandeep V Pandit3.   

Abstract

This review focuses on the (mal)adaptive processes in atrial excitation-contraction coupling occurring in patients with chronic atrial fibrillation. Cellular remodeling includes shortening of the atrial action potential duration and effective refractory period, depressed intracellular Ca2+ transient, and reduced myocyte contractility. Here we summarize the current knowledge of the ionic bases underlying these changes. Understanding the molecular mechanisms of excitation-contraction-coupling remodeling in the fibrillating human atria is important to identify new potential targets for AF therapy.

Entities:  

Year:  2012        PMID： 28496736      PMCID： PMC5153202          DOI： 10.4022/jafib.495

Source DB:  PubMed          Journal:  J Atr Fibrillation        ISSN： 1941-6911


  108 in total

1.  Ca(2+) handling in isolated human atrial myocardium.

Authors:  L S Maier; P Barckhausen; J Weisser; I Aleksic; M Baryalei; B Pieske
Journal:  Am J Physiol Heart Circ Physiol       Date:  2000-09       Impact factor: 4.733

2.  Regulation of the transient outward K(+) current by Ca(2+)/calmodulin-dependent protein kinases II in human atrial myocytes.

Authors:  S Tessier; P Karczewski; E G Krause; Y Pansard; C Acar; M Lang-Lazdunski; J J Mercadier; S N Hatem
Journal:  Circ Res       Date:  1999-10-29       Impact factor: 17.367

3.  Human atrial action potential and Ca2+ model: sinus rhythm and chronic atrial fibrillation.

Authors:  Eleonora Grandi; Sandeep V Pandit; Niels Voigt; Antony J Workman; Dobromir Dobrev; José Jalife; Donald M Bers
Journal:  Circ Res       Date:  2011-09-15       Impact factor: 17.367

4.  Alterations in contractile protein composition and function in human atrial dilatation and atrial fibrillation.

Authors:  S Eiras; N A Narolska; R B van Loon; N M Boontje; R Zaremba; C R Jimenez; F C Visser; W Stooker; J van der Velden; G J M Stienen
Journal:  J Mol Cell Cardiol       Date:  2006-08-09       Impact factor: 5.000

5.  Defective cardiac ryanodine receptor regulation during atrial fibrillation.

Authors:  John A Vest; Xander H T Wehrens; Steven R Reiken; Stephan E Lehnart; Dobromir Dobrev; Parag Chandra; Peter Danilo; Ursula Ravens; Michael R Rosen; Andrew R Marks
Journal:  Circulation       Date:  2005-04-26       Impact factor: 29.690

Review 6.  Mechanisms of termination and prevention of atrial fibrillation by drug therapy.

Authors:  A J Workman; G L Smith; A C Rankin
Journal:  Pharmacol Ther       Date:  2011-02-18       Impact factor: 12.310

Review 7.  Redox regulation of cardiac calcium channels and transporters.

Authors:  Aleksey V Zima; Lothar A Blatter
Journal:  Cardiovasc Res       Date:  2006-03-06       Impact factor: 10.787

8.  Differential alterations of receptor densities of three muscarinic acetylcholine receptor subtypes and current densities of the corresponding K+ channels in canine atria with atrial fibrillation induced by experimental congestive heart failure.

Authors:  Hong Shi; Huizhen Wang; Danshi Li; Stanley Nattel; Zhiguo Wang
Journal:  Cell Physiol Biochem       Date:  2004

9.  Sodium-calcium exchange initiated by the Ca2+ transient: an arrhythmia trigger within pulmonary veins.

Authors:  Eugene Patterson; Ralph Lazzara; Bela Szabo; Hong Liu; David Tang; Yu-Hua Li; Benjamin J Scherlag; Sunny S Po
Journal:  J Am Coll Cardiol       Date:  2006-02-23       Impact factor: 24.094

Review 10.  Calcium handling abnormalities in atrial fibrillation as a target for innovative therapeutics.

Authors:  Dobromir Dobrev; Stanley Nattel
Journal:  J Cardiovasc Pharmacol       Date:  2008-10       Impact factor: 3.105
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  2 in total

Review 1.  Ion Channels in the Heart.

Authors:  Daniel C Bartos; Eleonora Grandi; Crystal M Ripplinger
Journal:  Compr Physiol       Date:  2015-07-01       Impact factor: 9.090

2.  In Silico Assessment of Efficacy and Safety of IKur Inhibitors in Chronic Atrial Fibrillation: Role of Kinetics and State-Dependence of Drug Binding.

Authors:  Nicholas Ellinwood; Dobromir Dobrev; Stefano Morotti; Eleonora Grandi
Journal:  Front Pharmacol       Date:  2017-11-07       Impact factor: 5.810
  2 in total

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