Literature DB >> 18791467

Calcium handling abnormalities in atrial fibrillation as a target for innovative therapeutics.

Dobromir Dobrev1, Stanley Nattel.   

Abstract

Atrial electrical and structural alterations (remodeling) have emerged as key elements in the development of the atrial fibrillation (AF) substrate. Evidence points to abnormalities in intracellular Ca (calcium) handling as crucial links in AF-initiating focal activity and in perpetuation by rapidly firing foci and reentry. This review focuses on the molecular basis of altered Ca handling in AF, with the goal of providing new insights into molecular effective antiarrhythmic therapy.

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Year:  2008        PMID： 18791467     DOI： 10.1097/FJC.0b013e318171924d

Source DB:  PubMed          Journal:  J Cardiovasc Pharmacol        ISSN： 0160-2446            Impact factor:   3.105


  46 in total

1.  Ca(2+)-stimulated adenylyl cyclases regulate the L-type Ca(2+) current in guinea-pig atrial myocytes.

Authors:  Thomas P Collins; Derek A Terrar
Journal:  J Physiol       Date:  2012-02-20       Impact factor: 5.182

Review 2.  New developments in atrial antiarrhythmic drug therapy.

Authors:  Alexander Burashnikov; Charles Antzelevitch
Journal:  Nat Rev Cardiol       Date:  2010-03       Impact factor: 32.419

3.  Candidate gene approach to identifying rare genetic variants associated with lone atrial fibrillation.

Authors:  Peter Weeke; Babar Parvez; Marcia Blair; Laura Short; Christie Ingram; Gayle Kucera; Tanya Stubblefield; Dan M Roden; Dawood Darbar
Journal:  Heart Rhythm       Date:  2013-10-10       Impact factor: 6.343

Review 4.  Novel pharmacological targets for the rhythm control management of atrial fibrillation.

Authors:  Alexander Burashnikov; Charles Antzelevitch
Journal:  Pharmacol Ther       Date:  2011-08-17       Impact factor: 12.310

Review 5.  Ion Channels in the Heart.

Authors:  Daniel C Bartos; Eleonora Grandi; Crystal M Ripplinger
Journal:  Compr Physiol       Date:  2015-07-01       Impact factor: 9.090

6.  Mechanism for Triggered Waves in Atrial Myocytes.

Authors:  Yohannes Shiferaw; Gary L Aistrup; J Andrew Wasserstrom
Journal:  Biophys J       Date:  2017-08-08       Impact factor: 4.033

7.  Novel pharmacological approaches for antiarrhythmic therapy.

Authors:  Ursula Ravens
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  2010-01-15       Impact factor: 3.000

Review 8.  Cardiac adrenergic control and atrial fibrillation.

Authors:  Antony J Workman
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  2009-12-04       Impact factor: 3.000

Review 9.  Atrial Ca2+ signaling in atrial fibrillation as an antiarrhythmic drug target.

Authors:  Dobromir Dobrev
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  2009-09-26       Impact factor: 3.000

10.  Paraoxon attenuates vascular smooth muscle contraction through inhibiting Ca2+ influx in the rabbit thoracic aorta.

Authors:  Shouhong Zhou; Liying Liu; Xuhong Yang; Shujin Wu; Gengrong Chen
Journal:  J Biomed Biotechnol       Date:  2010-04-22
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