Literature DB >> 2849110

Structure and regulation of the rat 1,25-dihydroxyvitamin D3 receptor.

J K Burmester1, R J Wiese, N Maeda, H F DeLuca.   

Abstract

Complementary DNA clones encoding the entire rat 1,25-dihydroxyvitamin D3 receptor were isolated, and the total 423-amino acid sequence was deduced. The amino acid sequence of the rat receptor is similar but not identical to the reported human receptor sequence. The cysteine-rich DNA-binding domain is completely conserved and the steroid-binding domain is greater than 93% conserved between rat and human. The cDNA was used as a probe in blot analysis of polyadenylylated RNA to show that the 1,25-dihydroxyvitamin D3 receptor mRNA is a single 4.4-kilobase mRNA that is expressed in intestine and kidney, slightly expressed in heart, and not detectable in liver and spleen. The receptor mRNA concentration is markedly increased during development of the rat intestine between day 14 and day 21, in accord with previous results obtained by measurement of receptor concentration by ligand binding or immunoblotting.

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Year:  1988        PMID： 2849110      PMCID： PMC282780          DOI： 10.1073/pnas.85.24.9499

Source DB:  PubMed          Journal:  Proc Natl Acad Sci U S A        ISSN： 0027-8424            Impact factor:   11.205


  19 in total

1.  Rickets with alopecia: an inborn error of vitamin D metabolism.

Authors:  J F Rosen; A R Fleischman; L Finberg; A Hamstra; H F DeLuca
Journal:  J Pediatr       Date:  1979-05       Impact factor: 4.406

2.  Monoclonal antibodies to the porcine intestinal receptor for 1,25-dihydroxyvitamin D3: interaction with distinct receptor domains.

Authors:  M C Dame; E A Pierce; J M Prahl; C E Hayes; H F DeLuca
Journal:  Biochemistry       Date:  1986-08-12       Impact factor: 3.162

3.  Cloning and expression of full-length cDNA encoding human vitamin D receptor.

Authors:  A R Baker; D P McDonnell; M Hughes; T M Crisp; D J Mangelsdorf; M R Haussler; J W Pike; J Shine; B W O'Malley
Journal:  Proc Natl Acad Sci U S A       Date:  1988-05       Impact factor: 11.205

4.  A simple and very efficient method for generating cDNA libraries.

Authors:  U Gubler; B J Hoffman
Journal:  Gene       Date:  1983-11       Impact factor: 3.688

5.  Appearance of the intestinal cytosolic receptor for 1,25-dihydroxyvitamin D3 during neonatal development in the rat.

Authors:  B P Halloran; H F DeLuca
Journal:  J Biol Chem       Date:  1981-07-25       Impact factor: 5.157

6.  A cellular defect in hereditary vitamin-D-dependent rickets type II: defective nuclear uptake of 1,25-dihydroxyvitamin D in cultured skin fibroblasts.

Authors:  C Eil; U A Liberman; J F Rosen; S J Marx
Journal:  N Engl J Med       Date:  1981-06-25       Impact factor: 91.245

7.  DNA sequencing with chain-terminating inhibitors.

Authors:  F Sanger; S Nicklen; A R Coulson
Journal:  Proc Natl Acad Sci U S A       Date:  1977-12       Impact factor: 11.205

8.  Purification of chicken intestinal receptor for 1 alpha, 25-dihydroxyvitamin D3 to apparent homogeneity.

Authors:  R U Simpson; H F DeLuca
Journal:  Proc Natl Acad Sci U S A       Date:  1982-01       Impact factor: 11.205

9.  Identification of the porcine intestinal 1,25-dihydroxyvitamin D3 receptor on sodium dodecyl sulfate/polyacrylamide gels by renaturation and immunoblotting.

Authors:  M C Dame; E A Pierce; H F DeLuca
Journal:  Proc Natl Acad Sci U S A       Date:  1985-12       Impact factor: 11.205

Review 10.  Vitamin D: recent advances.

Authors:  H F DeLuca; H K Schnoes
Journal:  Annu Rev Biochem       Date:  1983       Impact factor: 23.643
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  15 in total

Review 1.  Evolution and function of the NR1I nuclear hormone receptor subfamily (VDR, PXR, and CAR) with respect to metabolism of xenobiotics and endogenous compounds.

Authors:  E J Reschly; Matthew D Krasowski
Journal:  Curr Drug Metab       Date:  2006-05       Impact factor: 3.731

2.  Overproduction of rat 1,25-dihydroxyvitamin D3 receptor in insect cells using the baculovirus expression system.

Authors:  T K Ross; J M Prahl; H F DeLuca
Journal:  Proc Natl Acad Sci U S A       Date:  1991-08-01       Impact factor: 11.205

3.  Cloning and characterization of the mouse vitamin D receptor promoter.

Authors:  F Jehan; H F DeLuca
Journal:  Proc Natl Acad Sci U S A       Date:  1997-09-16       Impact factor: 11.205

4.  Hyperresponsiveness of vitamin D receptor gene expression to 1,25-dihydroxyvitamin D3. A new characteristic of genetic hypercalciuric stone-forming rats.

Authors:  J Yao; P Kathpalia; D A Bushinsky; M J Favus
Journal:  J Clin Invest       Date:  1998-05-15       Impact factor: 14.808

5.  The avian vitamin D receptors: primary structures and their origins.

Authors:  M A Elaroussi; J M Prahl; H F DeLuca
Journal:  Proc Natl Acad Sci U S A       Date:  1994-11-22       Impact factor: 11.205

6.  H-2RIIBP, a member of the nuclear hormone receptor superfamily that binds to both the regulatory element of major histocompatibility class I genes and the estrogen response element.

Authors:  K Hamada; S L Gleason; B Z Levi; S Hirschfeld; E Appella; K Ozato
Journal:  Proc Natl Acad Sci U S A       Date:  1989-11       Impact factor: 11.205

7.  Multiple promoters direct the tissue-specific expression of novel N-terminal variant human vitamin D receptor gene transcripts.

Authors:  L A Crofts; M S Hancock; N A Morrison; J A Eisman
Journal:  Proc Natl Acad Sci U S A       Date:  1998-09-01       Impact factor: 11.205

8.  Two mutations in the hormone binding domain of the vitamin D receptor cause tissue resistance to 1,25 dihydroxyvitamin D3.

Authors:  K Kristjansson; A R Rut; M Hewison; J L O'Riordan; M R Hughes
Journal:  J Clin Invest       Date:  1993-07       Impact factor: 14.808

9.  Human vitamin D receptor is selectively phosphorylated by protein kinase C on serine 51, a residue crucial to its trans-activation function.

Authors:  J C Hsieh; P W Jurutka; M A Galligan; C M Terpening; C A Haussler; D S Samuels; Y Shimizu; N Shimizu; M R Haussler
Journal:  Proc Natl Acad Sci U S A       Date:  1991-10-15       Impact factor: 11.205

10.  Vitamin D receptor contains multiple dimerization interfaces that are functionally different.

Authors:  J Nishikawa; M Kitaura; M Imagawa; T Nishihara
Journal:  Nucleic Acids Res       Date:  1995-02-25       Impact factor: 16.971
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