Literature DB >> 2848922

Expression of two distinct T cell receptor alpha/beta heterodimers by an antigen-specific T cell clone.

L A Matis1, A Ezquerra, J E Coligan.   

Abstract

A cytochrome c-specific, MHC-restricted T cell clone with two complete rearrangements of the same V beta 1 gene element was shown to express two different TCR alpha/beta heterodimers. Antipeptide antisera specific for TCR C beta 1 and C beta 2 peptides each immunoprecipitated distinct disulfide-linked cell surface heterodimers. The clone was derived from immunized allogeneic chimeric mice, and displayed multiple Ia specificities, including the ability to recognize antigen in association with both I-Ek and I-Es Ia molecules, as well as alloreactivity to the I-Eb molecule. It will be important to determine whether each receptor contributes independently to the overall specificity of the clone.

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Year:  1988        PMID： 2848922      PMCID： PMC2189151          DOI： 10.1084/jem.168.6.2379

Source DB:  PubMed          Journal:  J Exp Med        ISSN： 0022-1007            Impact factor:   14.307


  16 in total

1.  Transfer of specificity by murine alpha and beta T-cell receptor genes.

Authors:  Z Dembić; W Haas; S Weiss; J McCubrey; H Kiefer; H von Boehmer; M Steinmetz
Journal:  Nature       Date:  1986 Mar 20-26       Impact factor: 49.962

2.  Correlations between T-cell specificity and the structure of the antigen receptor.

Authors:  P J Fink; L A Matis; D L McElligott; M Bookman; S M Hedrick
Journal:  Nature       Date:  1986 May 15-21       Impact factor: 49.962

3.  Two distinct mechanisms account for the immune response (Ir) gene control of the T cell response to pigeon cytochrome c.

Authors:  D L McElligott; S B Sorger; L A Matis; S M Hedrick
Journal:  J Immunol       Date:  1988-06-15       Impact factor: 5.422

4.  Alternative protein products with different carboxyl termini from a single class I gene, H-2Kb.

Authors:  A M Lew; D H Margulies; W L Maloy; E P Lillehoj; J McCluskey; J E Coligan
Journal:  Proc Natl Acad Sci U S A       Date:  1986-08       Impact factor: 11.205

Review 5.  The molecular genetics of the T-cell antigen receptor and T-cell antigen recognition.

Authors:  M Kronenberg; G Siu; L E Hood; N Shastri
Journal:  Annu Rev Immunol       Date:  1986       Impact factor: 28.527

6.  Bone marrow-derived thymic antigen-presenting cells determine self-recognition of Ia-restricted T lymphocytes.

Authors:  D L Longo; A M Kruisbeek; M L Davis; L A Matis
Journal:  Proc Natl Acad Sci U S A       Date:  1985-09       Impact factor: 11.205

7.  Aberrant rearrangements contribute significantly to the allelic exclusion of immunoglobulin gene expression.

Authors:  C Coleclough; R P Perry; K Karjalainen; M Weigert
Journal:  Nature       Date:  1981-04-02       Impact factor: 49.962

8.  Predominant use of a V alpha gene segment in mouse T-cell receptors for cytochrome c.

Authors:  A Winoto; J L Urban; N C Lan; J Goverman; L Hood; D Hansburg
Journal:  Nature       Date:  1986 Dec 18-31       Impact factor: 49.962

9.  Generation of diversity in T cell receptor repertoire specific for pigeon cytochrome c.

Authors:  S B Sorger; S M Hedrick; P J Fink; M A Bookman; L A Matis
Journal:  J Exp Med       Date:  1987-02-01       Impact factor: 14.307

10.  Transgenic mice with mu and kappa genes encoding antiphosphorylcholine antibodies.

Authors:  U Storb; C Pinkert; B Arp; P Engler; K Gollahon; J Manz; W Brady; R L Brinster
Journal:  J Exp Med       Date:  1986-08-01       Impact factor: 14.307
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  5 in total

1.  Molecular identification of T cells that respond in a primary bulk culture to a peptide derived from a platelet glycoprotein implicated in neonatal alloimmune thrombocytopenia.

Authors:  K Maslanka; M Yassai; J Gorski
Journal:  J Clin Invest       Date:  1996-10-15       Impact factor: 14.808

Review 2.  Analysis of the immune system with transgenic mice: T cell development.

Authors:  H Bluethmann
Journal:  Experientia       Date:  1991-09-15

3.  T cell receptor genes in a series of class I major histocompatibility complex-restricted cytotoxic T lymphocyte clones specific for a Plasmodium berghei nonapeptide: implications for T cell allelic exclusion and antigen-specific repertoire.

Authors:  J L Casanova; P Romero; C Widmann; P Kourilsky; J L Maryanski
Journal:  J Exp Med       Date:  1991-12-01       Impact factor: 14.307

4.  Preferential V beta gene usage and lack of junctional sequence conservation among human T cell receptors specific for a tetanus toxin-derived peptide: evidence for a dominant role of a germline-encoded V region in antigen/major histocompatibility complex recognition.

Authors:  B Boitel; M Ermonval; P Panina-Bordignon; R A Mariuzza; A Lanzavecchia; O Acuto
Journal:  J Exp Med       Date:  1992-03-01       Impact factor: 14.307

5.  Immunoglobulin (Ig) mu, kappa transgenic mice express transgenic idiotype on endogenously rearranged IgM and IgA molecules by secretion of chimeric molecules.

Authors:  Q Vos; R J Hodes
Journal:  J Exp Med       Date:  1992-10-01       Impact factor: 14.307
  5 in total

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