Literature DB >> 6783959

Aberrant rearrangements contribute significantly to the allelic exclusion of immunoglobulin gene expression.

C Coleclough, R P Perry, K Karjalainen, M Weigert.   

Abstract

A study of the organization of light- and heavy-chain immunoglobulin genes in mouse splenic B cells, spleen-derived hybridomas and plasmacytomas has unequivocally demonstrated that aberrant rearrangements are common during normal B-cell development. The results support a probabilistic model for allelic exclusion of immunoglobulin gene expression.

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Year:  1981        PMID： 6783959     DOI： 10.1038/290372a0

Source DB:  PubMed          Journal:  Nature        ISSN： 0028-0836            Impact factor:   49.962


  109 in total

Review 1.  Receptor selection in B and T lymphocytes.

Authors:  D Nemazee
Journal:  Annu Rev Immunol       Date:  2000       Impact factor: 28.527

Review 2.  Double light chain producing lymphocytes: an enigma of allelic exclusion.

Authors:  L Diaw; D Siwarski; K Huppi
Journal:  Immunol Res       Date:  2001       Impact factor: 2.829

3.  RNA surveillance down-regulates expression of nonfunctional kappa alleles and detects premature termination within the last kappa exon.

Authors:  Laurent Delpy; Christophe Sirac; Emmanuelle Magnoux; Sophie Duchez; Michel Cogné
Journal:  Proc Natl Acad Sci U S A       Date:  2004-05-03       Impact factor: 11.205

4.  Induction of Ig light chain gene rearrangement in heavy chain-deficient B cells by activated Ras.

Authors:  A C Shaw; W Swat; L Davidson; F W Alt
Journal:  Proc Natl Acad Sci U S A       Date:  1999-03-02       Impact factor: 11.205

Review 5.  Allelic exclusion of immunoglobulin genes: models and mechanisms.

Authors:  Christian Vettermann; Mark S Schlissel
Journal:  Immunol Rev       Date:  2010-09       Impact factor: 12.988

6.  Two conserved essential motifs of the murine immunoglobulin lambda enhancers bind B-cell-specific factors.

Authors:  C M Rudin; U Storb
Journal:  Mol Cell Biol       Date:  1992-01       Impact factor: 4.272

7.  Kappa chain monoallelic demethylation and the establishment of allelic exclusion.

Authors:  R Mostoslavsky; N Singh; A Kirillov; R Pelanda; H Cedar; A Chess; Y Bergman
Journal:  Genes Dev       Date:  1998-06-15       Impact factor: 11.361

8.  Pro-B cells sense productive immunoglobulin heavy chain rearrangement irrespective of polypeptide production.

Authors:  Johannes Lutz; Marinus R Heideman; Edith Roth; Paul van den Berk; Werner Müller; Chander Raman; Matthias Wabl; Heinz Jacobs; Hans-Martin Jäck
Journal:  Proc Natl Acad Sci U S A       Date:  2011-06-13       Impact factor: 11.205

9.  Lipopolysaccharide-induced transcription of the kappa immunoglobulin locus occurs on both alleles and is independent of methylation status.

Authors:  K J Nelson; E L Mather; R P Perry
Journal:  Nucleic Acids Res       Date:  1984-02-24       Impact factor: 16.971

10.  Different joining region J elements of the murine kappa immunoglobulin light chain locus are used at markedly different frequencies.

Authors:  D L Wood; C Coleclough
Journal:  Proc Natl Acad Sci U S A       Date:  1984-08       Impact factor: 11.205
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