Literature DB >> 28473593

Molecular Imaging of PARP.

Brandon Carney1,2, Susanne Kossatz1, Thomas Reiner3,4.   

Abstract

The poly(adenosine diphosphate-ribose)polymerase (PARP) family of enzymes is an important factor in the cellular DNA damage response and has gained much attention for its role in many diseases, particularly cancer. Targeted molecular imaging of PARP using fluorescent or radiolabeled tags has followed on the success of therapeutic inhibitors and gained momentum over the past few years. This review covers PARP imaging from the very first imaging agents up to the current state of the technology, with a focus on the clinical applications made possible by these agents.
© 2017 by the Society of Nuclear Medicine and Molecular Imaging.

Entities:  

Keywords:  PARP; PET; SPECT; fluorescence; optical; translation

Mesh：

Substances：

Year:  2017        PMID： 28473593      PMCID： PMC5493005          DOI： 10.2967/jnumed.117.189936

Source DB:  PubMed          Journal:  J Nucl Med        ISSN： 0161-5505            Impact factor:   10.057


  37 in total

1.  Laying a trap to kill cancer cells: PARP inhibitors and their mechanisms of action.

Authors:  Yves Pommier; Mark J O'Connor; Johann de Bono
Journal:  Sci Transl Med       Date:  2016-10-26       Impact factor: 17.956

2.  Dual-Modality Optical/PET Imaging of PARP1 in Glioblastoma.

Authors:  Giuseppe Carlucci; Brandon Carney; Christian Brand; Susanne Kossatz; Christopher P Irwin; Sean D Carlin; Edmund J Keliher; Wolfgang Weber; Thomas Reiner
Journal:  Mol Imaging Biol       Date:  2015-12       Impact factor: 3.488

3.  PET of Poly (ADP-Ribose) Polymerase Activity in Cancer: Preclinical Assessment and First In-Human Studies.

Authors:  Loren S Michel; Samantha Dyroff; Frank J Brooks; Katherine J Spayd; Sora Lim; Jacquelyn T Engle; Sharon Phillips; Benjamin Tan; Andrea Wang-Gillam; Christopher Bognar; Wenhua Chu; Dong Zhou; Robert H Mach; Richard Laforest; Delphine L Chen
Journal:  Radiology       Date:  2016-11-14       Impact factor: 11.105

4.  Diabetic endothelial dysfunction: the role of poly(ADP-ribose) polymerase activation.

Authors:  L Virág; P Jagtap; E Szabó; J G Mabley; L Liaudet; A Marton; D G Hoyt; K G Murthy; A L Salzman; G J Southan; C Szabó
Journal:  Nat Med       Date:  2001-01       Impact factor: 53.440

5.  Efficient acid-catalyzed (18) F/(19) F fluoride exchange of BODIPY dyes.

Authors:  Edmund J Keliher; Jenna A Klubnick; Thomas Reiner; Ralph Mazitschek; Ralph Weissleder
Journal:  ChemMedChem       Date:  2014-03-05       Impact factor: 3.466

6.  Synthesis and Evaluation of a Radioiodinated Tracer with Specificity for Poly(ADP-ribose) Polymerase-1 (PARP-1) in Vivo.

Authors:  Filip Zmuda; Gaurav Malviya; Adele Blair; Marie Boyd; Anthony J Chalmers; Andrew Sutherland; Sally L Pimlott
Journal:  J Med Chem       Date:  2015-10-27       Impact factor: 7.446

7.  Diffuse intrinsic pontine glioma: poised for progress.

Authors:  Katherine E Warren
Journal:  Front Oncol       Date:  2012-12-28       Impact factor: 6.244

8.  Detection and delineation of oral cancer with a PARP1 targeted optical imaging agent.

Authors:  Susanne Kossatz; Christian Brand; Stanley Gutiontov; Jonathan T C Liu; Nancy Y Lee; Mithat Gönen; Wolfgang A Weber; Thomas Reiner
Journal:  Sci Rep       Date:  2016-02-22       Impact factor: 4.379

9.  A Radiotracer Strategy to Quantify PARP-1 Expression In Vivo Provides a Biomarker That Can Enable Patient Selection for PARP Inhibitor Therapy.

Authors:  Mehran Makvandi; Kuiying Xu; Brian P Lieberman; Redmond-Craig Anderson; Samuel Sander Effron; Harrison D Winters; Chenbo Zeng; Elizabeth S McDonald; Daniel A Pryma; Roger A Greenberg; Robert H Mach
Journal:  Cancer Res       Date:  2016-06-03       Impact factor: 13.312

10.  Optical Imaging of PARP1 in Response to Radiation in Oral Squamous Cell Carcinoma.

Authors:  Susanne Kossatz; Wolfgang A Weber; Thomas Reiner
Journal:  PLoS One       Date:  2016-01-25       Impact factor: 3.240
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  35 in total

1.  Synthesis and evaluation of an AZD2461 [18F]PET probe in non-human primates reveals the PARP-1 inhibitor to be non-blood-brain barrier penetrant.

Authors:  Sean W Reilly; Laura N Puentes; Alexander Schmitz; Chia-Ju Hsieh; Chi-Chang Weng; Catherine Hou; Shihong Li; Yin-Ming Kuo; Prashanth Padakanti; Hsiaoju Lee; Aladdin A Riad; Mehran Makvandi; Robert H Mach
Journal:  Bioorg Chem       Date:  2018-10-17       Impact factor: 5.275

2.  Examination of Diazaspiro Cores as Piperazine Bioisosteres in the Olaparib Framework Shows Reduced DNA Damage and Cytotoxicity.

Authors:  Sean W Reilly; Laura N Puentes; Khadija Wilson; Chia-Ju Hsieh; Chi-Chang Weng; Mehran Makvandi; Robert H Mach
Journal:  J Med Chem       Date:  2018-06-14       Impact factor: 7.446

3.  Fluorine-18 labeled poly (ADP-ribose) polymerase1 inhibitor as a potential alternative to 2-deoxy-2-[18F]fluoro-d-glucose positron emission tomography in oral cancer imaging.

Authors:  Paula Demétrio de Souza França; Sheryl Roberts; Susanne Kossatz; Navjot Guru; Christian Mason; Daniella Karassawa Zanoni; Marcio Abrahão; Heiko Schöder; Ian Ganly; Snehal G Patel; Thomas Reiner
Journal:  Nucl Med Biol       Date:  2020-01-23       Impact factor: 2.408

4.  Targeted PET imaging strategy to differentiate malignant from inflamed lymph nodes in diffuse large B-cell lymphoma.

Authors:  Jun Tang; Darin Salloum; Brandon Carney; Christian Brand; Susanne Kossatz; Ahmad Sadique; Jason S Lewis; Wolfgang A Weber; Hans-Guido Wendel; Thomas Reiner
Journal:  Proc Natl Acad Sci U S A       Date:  2017-08-21       Impact factor: 11.205

5.  Direct Imaging of Drug Distribution and Target Engagement of the PARP Inhibitor Rucaparib.

Authors:  Susanne Kossatz; Brandon Carney; Christopher Farley; Wolfgang A Weber; Charles M Drain; Thomas Reiner
Journal:  J Nucl Med       Date:  2018-03-23       Impact factor: 10.057

6.  PARP-1-Targeted Radiotherapy in Mouse Models of Glioblastoma.

Authors:  Stephen A Jannetti; Giuseppe Carlucci; Brandon Carney; Susanne Kossatz; Larissa Shenker; Lukas M Carter; Beatriz Salinas; Christian Brand; Ahmad Sadique; Patrick L Donabedian; Kristen M Cunanan; Mithat Gönen; Vladimir Ponomarev; Brian M Zeglis; Mark M Souweidane; Jason S Lewis; Wolfgang A Weber; John L Humm; Thomas Reiner
Journal:  J Nucl Med       Date:  2018-03-23       Impact factor: 10.057

7.  Smartphone epifluorescence microscopy for cellular imaging of fresh tissue in low-resource settings.

Authors:  Wenbin Zhu; Giacomo Pirovano; Patrick K O'Neal; Cheng Gong; Nachiket Kulkarni; Christopher D Nguyen; Christian Brand; Thomas Reiner; Dongkyun Kang
Journal:  Biomed Opt Express       Date:  2019-12-06       Impact factor: 3.732

8.  Targeted Brain Tumor Radiotherapy Using an Auger Emitter.

Authors:  Giacomo Pirovano; Stephen A Jannetti; Lukas M Carter; Ahmad Sadique; Susanne Kossatz; Navjot Guru; Paula Demétrio De Souza França; Masatomo Maeda; Brian M Zeglis; Jason S Lewis; John L Humm; Thomas Reiner
Journal:  Clin Cancer Res       Date:  2020-02-17       Impact factor: 12.531

9.  Safety and Feasibility of PARP1/2 Imaging with 18F-PARPi in Patients with Head and Neck Cancer.

Authors:  Heiko Schöder; Paula Demétrio De Souza França; Reiko Nakajima; Eva Burnazi; Sheryl Roberts; Christian Brand; Milan Grkovski; Audrey Mauguen; Mark P Dunphy; Ronald A Ghossein; Serge K Lyashchenko; Jason S Lewis; Joseph A O'Donoghue; Ian Ganly; Snehal G Patel; Nancy Y Lee; Thomas Reiner
Journal:  Clin Cancer Res       Date:  2020-04-03       Impact factor: 12.531

10.  Nanoemulsion-Based Delivery of Fluorescent PARP Inhibitors in Mouse Models of Small Cell Lung Cancer.

Authors:  Junior Gonzales; Susanne Kossatz; Sheryl Roberts; Giacomo Pirovano; Christian Brand; Carlos Pérez-Medina; Patrick Donabedian; M Jason de la Cruz; Willem J M Mulder; Thomas Reiner
Journal:  Bioconjug Chem       Date:  2018-11-07       Impact factor: 4.774
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