M V Spampinato1,2, C Chan3,2, J H Jensen3,2, J A Helpern3,2,4, L Bonilha4, S A Kautz5,6, P J Nietert7, W Feng7,4. 1. From the Department of Radiology and Radiological Science (M.V.S., C.C., J.H.J., J.A.H.) spampin@musc.edu. 2. Center for Biomedical Imaging (M.V.S., C.C., J.H.J., J.A.H.). 3. From the Department of Radiology and Radiological Science (M.V.S., C.C., J.H.J., J.A.H.). 4. Department of Neurology (L.B., W.F., J.A.H.), Medical University of South Carolina, Charleston, South Carolina. 5. Department of Health Sciences and Research (S.A.K.). 6. Ralph H. Johnson VA Medical Center (S.A.K.), Charleston, South Carolina. 7. Department of Public Health Sciences (P.J.N., W.F.).
Abstract
BACKGROUND AND PURPOSE: Motor impairment is the most common deficit after stroke. Our aim was to evaluate whether diffusional kurtosis imaging can detect corticospinal tract microstructural changes in the acute phase for patients with first-ever ischemic stroke and motor impairment and to assess the correlations between diffusional kurtosis imaging-derived diffusion metrics for the corticospinal tract and motor impairment 3 months poststroke. MATERIALS AND METHODS: We evaluated 17 patients with stroke who underwent brain MR imaging including diffusional kurtosis imaging within 4 days after the onset of symptoms. Neurologic evaluation included the Fugl-Meyer Upper Extremity Motor scale in the acute phase and 3 months poststroke. For the corticospinal tract in the lesioned and contralateral hemispheres, we estimated with diffusional kurtosis imaging both pure diffusion metrics, such as the mean diffusivity and mean kurtosis, and model-dependent quantities, such as the axonal water fraction. We evaluated the correlations between corticospinal tract diffusion metrics and the Fugl-Meyer Upper Extremity Motor scale at 3 months. RESULTS: Among all the diffusion metrics, the largest percentage signal changes of the lesioned hemisphere corticospinal tract were observed with axial kurtosis, with an average 12% increase compared with the contralateral corticospinal tract. The strongest associations between the 3-month Fugl-Meyer Upper Extremity Motor scale score and diffusion metrics were found for the lesioned/contralateral hemisphere corticospinal tract mean kurtosis (ρ = -0.85) and axial kurtosis (ρ = -0.78) ratios. CONCLUSIONS: This study was designed to be one of hypothesis generation. Diffusion metrics related to kurtosis were found to be more sensitive than conventional diffusivity metrics to early poststroke corticospinal tract microstructural changes and may have potential value in the prediction of motor impairment at 3 months.
BACKGROUND AND PURPOSE:Motor impairment is the most common deficit after stroke. Our aim was to evaluate whether diffusional kurtosis imaging can detect corticospinal tract microstructural changes in the acute phase for patients with first-ever ischemic stroke and motor impairment and to assess the correlations between diffusional kurtosis imaging-derived diffusion metrics for the corticospinal tract and motor impairment 3 months poststroke. MATERIALS AND METHODS: We evaluated 17 patients with stroke who underwent brain MR imaging including diffusional kurtosis imaging within 4 days after the onset of symptoms. Neurologic evaluation included the Fugl-Meyer Upper Extremity Motor scale in the acute phase and 3 months poststroke. For the corticospinal tract in the lesioned and contralateral hemispheres, we estimated with diffusional kurtosis imaging both pure diffusion metrics, such as the mean diffusivity and mean kurtosis, and model-dependent quantities, such as the axonal water fraction. We evaluated the correlations between corticospinal tract diffusion metrics and the Fugl-Meyer Upper Extremity Motor scale at 3 months. RESULTS: Among all the diffusion metrics, the largest percentage signal changes of the lesioned hemisphere corticospinal tract were observed with axial kurtosis, with an average 12% increase compared with the contralateral corticospinal tract. The strongest associations between the 3-month Fugl-Meyer Upper Extremity Motor scale score and diffusion metrics were found for the lesioned/contralateral hemisphere corticospinal tract mean kurtosis (ρ = -0.85) and axial kurtosis (ρ = -0.78) ratios. CONCLUSIONS: This study was designed to be one of hypothesis generation. Diffusion metrics related to kurtosis were found to be more sensitive than conventional diffusivity metrics to early poststroke corticospinal tract microstructural changes and may have potential value in the prediction of motor impairment at 3 months.
Authors: Edward S Hui; Els Fieremans; Jens H Jensen; Ali Tabesh; Wuwei Feng; Leonardo Bonilha; Maria V Spampinato; Robert Adams; Joseph A Helpern Journal: Stroke Date: 2012-08-28 Impact factor: 7.914
Authors: Benjamin N Groisser; William A Copen; Aneesh B Singhal; Kelsi K Hirai; Judith D Schaechter Journal: Neurorehabil Neural Repair Date: 2014-02-11 Impact factor: 3.919
Authors: Valentina Panara; R Navarra; P A Mattei; E Piccirilli; V Bartoletti; A Uncini; M Caulo Journal: Neuroradiology Date: 2018-12-05 Impact factor: 2.804
Authors: Adrian G Guggisberg; Philipp J Koch; Friedhelm C Hummel; Cathrin M Buetefisch Journal: Clin Neurophysiol Date: 2019-04-15 Impact factor: 3.708
Authors: Lian Li; Michael Chopp; Guangliang Ding; Esmaeil Davoodi-Bojd; Qingjiang Li; Asim Mahmood; Ye Xiong; Quan Jiang Journal: Brain Res Date: 2019-04-19 Impact factor: 3.252
Authors: E V R DiBella; A Sharma; L Richards; V Prabhakaran; J J Majersik; S K HashemizadehKolowri Journal: AJNR Am J Neuroradiol Date: 2022-03-10 Impact factor: 3.825
Authors: C Li; C Lan; X Zhang; L Yin; X Hao; J Tian; L Lin; H Sun; Z Yao; X Feng; J Jia; Y Yang Journal: Cell Transplant Date: 2019-03-25 Impact factor: 4.064