Literature DB >> 28466900

Synthetic multivalent V3 glycopeptides display enhanced recognition by glycan-dependent HIV-1 broadly neutralizing antibodies.

Hui Cai1, Jared Orwenyo1, Javier Guenaga2, John Giddens1, Christian Toonstra1, Richard T Wyatt2, Lai-Xi Wang1.   

Abstract

We describe here the synthesis of novel multivalent HIV V3 domain glycopeptides and their binding to broadly neutralizing antibodies PGT128 and 10-1074. Our binding data reveal a distinct mode of antigen recognition by the two antibodies and further suggest that multivalent glycopeptides could mimic the neutralizing epitopes more efficiently than the monomeric glycopeptide.

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Year:  2017        PMID： 28466900      PMCID： PMC5518472          DOI： 10.1039/c7cc02059g

Source DB:  PubMed          Journal:  Chem Commun (Camb)        ISSN： 1359-7345            Impact factor:   6.222


  34 in total

1.  Effect of bivalent interaction upon apparent antibody affinity: experimental confirmation of theory using fluorescence photobleaching and implications for antibody binding assays.

Authors:  E N Kaufman; R K Jain
Journal:  Cancer Res       Date:  1992-08-01       Impact factor: 12.701

2.  Multivalency as a chemical organization and action principle.

Authors:  Carlo Fasting; Christoph A Schalley; Marcus Weber; Oliver Seitz; Stefan Hecht; Beate Koksch; Jens Dernedde; Christina Graf; Ernst-Walter Knapp; Rainer Haag
Journal:  Angew Chem Int Ed Engl       Date:  2012-09-05       Impact factor: 15.336

3.  Structure of HIV-1 gp120 V1/V2 domain with broadly neutralizing antibody PG9.

Authors:  Jason S McLellan; Marie Pancera; Chris Carrico; Jason Gorman; Jean-Philippe Julien; Reza Khayat; Robert Louder; Robert Pejchal; Mallika Sastry; Kaifan Dai; Sijy O'Dell; Nikita Patel; Syed Shahzad-ul-Hussan; Yongping Yang; Baoshan Zhang; Tongqing Zhou; Jiang Zhu; Jeffrey C Boyington; Gwo-Yu Chuang; Devan Diwanji; Ivelin Georgiev; Young Do Kwon; Doyung Lee; Mark K Louder; Stephanie Moquin; Stephen D Schmidt; Zhi-Yong Yang; Mattia Bonsignori; John A Crump; Saidi H Kapiga; Noel E Sam; Barton F Haynes; Dennis R Burton; Wayne C Koff; Laura M Walker; Sanjay Phogat; Richard Wyatt; Jared Orwenyo; Lai-Xi Wang; James Arthos; Carole A Bewley; John R Mascola; Gary J Nabel; William R Schief; Andrew B Ward; Ian A Wilson; Peter D Kwong
Journal:  Nature       Date:  2011-11-23       Impact factor: 49.962

4.  Rational design of envelope identifies broadly neutralizing human monoclonal antibodies to HIV-1.

Authors:  Xueling Wu; Zhi-Yong Yang; Yuxing Li; Carl-Magnus Hogerkorp; William R Schief; Michael S Seaman; Tongqing Zhou; Stephen D Schmidt; Lan Wu; Ling Xu; Nancy S Longo; Krisha McKee; Sijy O'Dell; Mark K Louder; Diane L Wycuff; Yu Feng; Martha Nason; Nicole Doria-Rose; Mark Connors; Peter D Kwong; Mario Roederer; Richard T Wyatt; Gary J Nabel; John R Mascola
Journal:  Science       Date:  2010-07-08       Impact factor: 47.728

5.  A potent and broad neutralizing antibody recognizes and penetrates the HIV glycan shield.

Authors:  Robert Pejchal; Katie J Doores; Laura M Walker; Reza Khayat; Po-Ssu Huang; Sheng-Kai Wang; Robyn L Stanfield; Jean-Philippe Julien; Alejandra Ramos; Max Crispin; Rafael Depetris; Umesh Katpally; Andre Marozsan; Albert Cupo; Sebastien Maloveste; Yan Liu; Ryan McBride; Yukishige Ito; Rogier W Sanders; Cassandra Ogohara; James C Paulson; Ten Feizi; Christopher N Scanlan; Chi-Huey Wong; John P Moore; William C Olson; Andrew B Ward; Pascal Poignard; William R Schief; Dennis R Burton; Ian A Wilson
Journal:  Science       Date:  2011-10-13       Impact factor: 47.728

6.  Mutants of Mucor hiemalis endo-beta-N-acetylglucosaminidase show enhanced transglycosylation and glycosynthase-like activities.

Authors:  Midori Umekawa; Wei Huang; Bing Li; Kiyotaka Fujita; Hisashi Ashida; Lai-Xi Wang; Kenji Yamamoto
Journal:  J Biol Chem       Date:  2007-12-20       Impact factor: 5.157

7.  Broad and potent neutralizing antibodies from an African donor reveal a new HIV-1 vaccine target.

Authors:  Laura M Walker; Sanjay K Phogat; Po-Ying Chan-Hui; Denise Wagner; Pham Phung; Julie L Goss; Terri Wrin; Melissa D Simek; Steven Fling; Jennifer L Mitcham; Jennifer K Lehrman; Frances H Priddy; Ole A Olsen; Steven M Frey; Phillip W Hammond; Stephen Kaminsky; Timothy Zamb; Matthew Moyle; Wayne C Koff; Pascal Poignard; Dennis R Burton
Journal:  Science       Date:  2009-09-03       Impact factor: 47.728

8.  Glycosynthases enable a highly efficient chemoenzymatic synthesis of N-glycoproteins carrying intact natural N-glycans.

Authors:  Wei Huang; Cishan Li; Bing Li; Midori Umekawa; Kenji Yamamoto; Xinyu Zhang; Lai-Xi Wang
Journal:  J Am Chem Soc       Date:  2009-02-18       Impact factor: 15.419

9.  Broad neutralization coverage of HIV by multiple highly potent antibodies.

Authors:  Laura M Walker; Michael Huber; Katie J Doores; Emilia Falkowska; Robert Pejchal; Jean-Philippe Julien; Sheng-Kai Wang; Alejandra Ramos; Po-Ying Chan-Hui; Matthew Moyle; Jennifer L Mitcham; Phillip W Hammond; Ole A Olsen; Pham Phung; Steven Fling; Chi-Huey Wong; Sanjay Phogat; Terri Wrin; Melissa D Simek; Wayne C Koff; Ian A Wilson; Dennis R Burton; Pascal Poignard
Journal:  Nature       Date:  2011-09-22       Impact factor: 49.962

10.  HIV therapy by a combination of broadly neutralizing antibodies in humanized mice.

Authors:  Ariel Halper-Stromberg; Joshua A Horwitz; Florian Klein; Henning Gruell; Johannes F Scheid; Stylianos Bournazos; Hugo Mouquet; Linda A Spatz; Ron Diskin; Alexander Abadir; Trinity Zang; Marcus Dorner; Eva Billerbeck; Rachael N Labitt; Christian Gaebler; Paola Marcovecchio; Reha-Baris Incesu; Thomas R Eisenreich; Paul D Bieniasz; Michael S Seaman; Pamela J Bjorkman; Jeffrey V Ravetch; Alexander Ploss; Michel C Nussenzweig
Journal:  Nature       Date:  2012-10-24       Impact factor: 49.962
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  11 in total

1.  Chemoenzymatic Synthesis of HIV-1 Glycopeptide Antigens.

Authors:  Guanghui Zong; Chao Li; Lai-Xi Wang
Journal:  Methods Mol Biol       Date:  2020

2.  Synthesis and Immunological Study of N-Glycan-Bacteriophage Qβ Conjugates Reveal Dominant Antibody Responses to the Conserved Chitobiose Core.

Authors:  Thomas C Donahue; Guanghui Zong; Nicholas A O'Brien; Chong Ou; Jeffrey C Gildersleeve; Lai-Xi Wang
Journal:  Bioconjug Chem       Date:  2022-06-10       Impact factor: 6.069

Review 3.  Chemoenzymatic Methods for the Synthesis of Glycoproteins.

Authors:  Chao Li; Lai-Xi Wang
Journal:  Chem Rev       Date:  2018-08-24       Impact factor: 60.622

4.  Synthetic HIV V3 Glycopeptide Immunogen Carrying a N334 N-Glycan Induces Glycan-Dependent Antibodies with Promiscuous Site Recognition.

Authors:  Hui Cai; Rou-Shu Zhang; Jared Orwenyo; John Giddens; Qiang Yang; Celia C LaBranche; David C Montefiori; Lai-Xi Wang
Journal:  J Med Chem       Date:  2018-11-08       Impact factor: 7.446

5.  Appropriate aglycone modification significantly expands the glycan substrate acceptability of α1,6-fucosyltransferase (FUT8).

Authors:  Roushu Zhang; Qiang Yang; Bhargavi M Boruah; Guanghui Zong; Chao Li; Digantkumar Chapla; Jeong-Yeh Yang; Kelley W Moremen; Lai-Xi Wang
Journal:  Biochem J       Date:  2021-04-30       Impact factor: 3.857

6.  Multivalent Antigen Presentation Enhances the Immunogenicity of a Synthetic Three-Component HIV-1 V3 Glycopeptide Vaccine.

Authors:  Hui Cai; Roushu Zhang; Jared Orwenyo; John Giddens; Qiang Yang; Celia C LaBranche; David C Montefiori; Lai-Xi Wang
Journal:  ACS Cent Sci       Date:  2018-05-07       Impact factor: 14.553

7.  Oligomannose Glycopeptide Conjugates Elicit Antibodies Targeting the Glycan Core Rather than Its Extremities.

Authors:  Dung N Nguyen; Bokai Xu; Robyn L Stanfield; Jennifer K Bailey; Satoru Horiya; J Sebastian Temme; Deborah R Leon; Celia C LaBranche; David C Montefiori; Catherine E Costello; Ian A Wilson; Isaac J Krauss
Journal:  ACS Cent Sci       Date:  2019-02-06       Impact factor: 14.553

8.  Star nanoparticles delivering HIV-1 peptide minimal immunogens elicit near-native envelope antibody responses in nonhuman primates.

Authors:  Joseph R Francica; Richard Laga; Geoffrey M Lynn; Gabriela Mužíková; Ladislav Androvič; Baptiste Aussedat; William E Walkowicz; Kartika Padhan; Ramiro Andrei Ramirez-Valdez; Robert Parks; Stephen D Schmidt; Barbara J Flynn; Yaroslav Tsybovsky; Guillaume B E Stewart-Jones; Kevin O Saunders; Faezzah Baharom; Constantinos Petrovas; Barton F Haynes; Robert A Seder
Journal:  PLoS Biol       Date:  2019-06-17       Impact factor: 9.593

9.  The Impact of Sustained Immunization Regimens on the Antibody Response to Oligomannose Glycans.

Authors:  Dung N Nguyen; Richard L Redman; Satoru Horiya; Jennifer K Bailey; Bokai Xu; Robyn L Stanfield; J Sebastian Temme; Celia C LaBranche; Shiyu Wang; Avital A Rodal; David C Montefiori; Ian A Wilson; Isaac J Krauss
Journal:  ACS Chem Biol       Date:  2020-03-09       Impact factor: 5.100

10.  Display of the HIV envelope protein at the yeast cell surface for immunogen development.

Authors:  Elizabeth Mathew; Hong Zhu; Sara M Connelly; Mark A Sullivan; Matthew G Brewer; Michael S Piepenbrink; James J Kobie; Stephen Dewhurst; Mark E Dumont
Journal:  PLoS One       Date:  2018-10-18       Impact factor: 3.240
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