Ricardo Cabrera1,2, Oscar Filevich3, Beatriz García-Acosta1, Jegath Athilingam4,5, Kevin J Bender4,5, Kira E Poskanzer4,6, Roberto Etchenique1. 1. Departamento de Química Inorgánica, Analítica y Química Física, INQUIMAE, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, CONICET, Ciudad Universitaria Pabellón 2, AR1428EHA Buenos Aires, Argentina. 2. Ciclo Básico Común, Universidad de Buenos Aires , 1053 Buenos Aires, Argentina. 3. Laboratorio de Neurobiología Molecular, BIOMED, Pontificia Universidad Católica Argentina, CONICET, C1107AFB Buenos Aires, Argentina. 4. Kavli Institute for Fundamental Neuroscience, UCSF Weill Institute for Neuroscience , San Francisco, California, United States. 5. Department of Neurology, University of California, San Francisco , San Francisco, California 94143, United States. 6. Department of Biochemistry and Biophysics, University of California, San Francisco , San Francisco, California 94143, United States.
Abstract
Serotonin, or 5-hydroxytryptamine (5HT), is an important neurotransmitter in the nervous system of both vertebrates and invertebrates. Deficits in 5HT signaling are responsible for many disabling psychiatric conditions, and its molecular machinery is the target of many pharmaceuticals. We present a new 5HT phototrigger, the compound [Ru(bpy)2(PMe3)(5HT)]2+, where PMe3 is trimethylphosphine. As with other ruthenium-bipyridyl based caged compounds, [Ru(bpy)2(PMe3)(5HT)]2+ presents activity in the visible region of the spectrum. We characterize and discuss the photochemical properties of the caged compound, and demonstrate its use by modulating the excitability of mouse prefrontal principal neurons.
Serotonin, or n class="Chemical">5-hydroxytryptamine (5HT), is an important neurotransmitter in the nervous system of both vertebrates and invertebrates. Deficits in 5HT signaling are responsible for many disabling psychiatric conditions, and its molecular machinery is the target of many pharmaceuticals. We present a new 5HT phototrigger, the compound [Ru(bpy)2(PMe3)(5HT)]2+, where PMe3 is trimethylphosphine. As with other ruthenium-bipyridyl based caged compounds, [Ru(bpy)2(PMe3)(5HT)]2+ presents activity in the visible region of the spectrum. We characterize and discuss the photochemical properties of the caged compound, and demonstrate its use by modulating the excitability of mouse prefrontal principal neurons.
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