Literature DB >> 28443192

The determination of a dose deposited in reference medium due to (p,n) reaction occurring during proton therapy.

Anna Dawidowska1, Monika Paluch Ferszt1, Adam Konefał1.   

Abstract

AIM: The aim of the investigation was to determine the undesirable dose coming from neutrons produced in reactions (p,n) in irradiated tissues represented by water.
BACKGROUND: Production of neutrons in the system of beam collimators and in irradiated tissues is the undesirable phenomenon related to the application of protons in radiotherapy. It makes that proton beams are contaminated by neutrons and patients receive the undesirable neutron dose.
MATERIALS AND METHODS: The investigation was based on the Monte Carlo simulations (GEANT4 code). The calculations were performed for five energies of protons: 50 MeV, 55 MeV, 60 MeV, 65 MeV and 75 MeV. The neutron doses were calculated on the basis of the neutron fluence and neutron energy spectra derived from simulations and by means of the neutron fluence-dose conversion coefficients taken from the ICRP dosimetry protocol no. 74 for the antero-posterior irradiation geometry.
RESULTS: The obtained neutron doses are much less than the proton ones. They do not exceed 0.1%, 0.4%, 0.5%, 0.6% and 0.7% of the total dose at a given depth for the primary protons with energy of 50 MeV, 55 MeV, 60 MeV, 65 MeV and 70 MeV, respectively.
CONCLUSIONS: The neutron production takes place mainly along the central axis of the beam. The maximum neutron dose appears at about a half of the depth of the maximum proton dose (Bragg peak), i.e. in the volume of a healthy tissue. The doses of neutrons produced in the irradiated medium (water) are about two orders of magnitude less than the proton doses for the considered range of energy of protons.

Entities:  

Keywords:  GEANT4; Monte Carlo; Neutrons; Proton therapy

Year:  2014        PMID: 28443192      PMCID: PMC5394717          DOI: 10.1016/j.rpor.2014.02.003

Source DB:  PubMed          Journal:  Rep Pract Oncol Radiother        ISSN: 1507-1367


  7 in total

1.  Secondary neutron doses for several beam configurations for proton therapy.

Authors:  Dongho Shin; Myonggeun Yoon; Jungwon Kwak; Jungwook Shin; Se Byeong Lee; Sung Yong Park; Soah Park; Dae Yong Kim; Kwan Ho Cho
Journal:  Int J Radiat Oncol Biol Phys       Date:  2009-05-01       Impact factor: 7.038

2.  Measurement of depth-dose of linear accelerator and simulation by use of Geant4 computer code.

Authors:  D Sardari; R Maleki; H Samavat; A Esmaeeli
Journal:  Rep Pract Oncol Radiother       Date:  2010-05-20

3.  Analysis of the physical interactions of therapeutic proton beams in water with the use of Geant4 Monte Carlo calculations.

Authors:  Zdenek Morávek; Ludwig Bogner
Journal:  Z Med Phys       Date:  2009       Impact factor: 4.820

4.  Comparison of MCNPX and Geant4 proton energy deposition predictions for clinical use.

Authors:  U Titt; B Bednarz; H Paganetti
Journal:  Phys Med Biol       Date:  2012-09-21       Impact factor: 3.609

5.  Optimizing radiotherapy of orbital and paraorbital tumors: intensity-modulated X-ray beams vs. intensity-modulated proton beams.

Authors:  R Miralbell; L Cella; D Weber; A Lomax
Journal:  Int J Radiat Oncol Biol Phys       Date:  2000-07-01       Impact factor: 7.038

6.  Locally challenging osteo- and chondrogenic tumors of the axial skeleton: results of combined proton and photon radiation therapy using three-dimensional treatment planning.

Authors:  E B Hug; M M Fitzek; N J Liebsch; J E Munzenrider
Journal:  Int J Radiat Oncol Biol Phys       Date:  1995-02-01       Impact factor: 7.038

Review 7.  Recent advances in light ion radiation therapy.

Authors:  Anders Brahme
Journal:  Int J Radiat Oncol Biol Phys       Date:  2004-02-01       Impact factor: 7.038

  7 in total
  2 in total

1.  Application of the phase-space distribution approach of Monte Carlo for radiation contamination dose estimation from the (n,γ), (γ,n) nuclear reactions and linac leakage photons in the megavoltage radiotherapy facility.

Authors:  Amir Ghasemi-Jangjoo; Hosein Ghiasi
Journal:  Rep Pract Oncol Radiother       Date:  2020-01-24

2.  Secondary particle production and physical properties during dose enhancement for spread-out Bragg peaks.

Authors:  Chulhwan Hwang; Jung Hoon Kim
Journal:  Transl Cancer Res       Date:  2019-08       Impact factor: 1.241

  2 in total

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