Literature DB >> 28431223

PINK1-Based Screen Shines Light on Autophagy Enhancers for Parkinson's Disease.

Dominik Haddad1, Ken Nakamura2.   

Abstract

In this issue of Cell Chemical Biology, Zhang et al. (2017) report a zebrafish model of Parkinson's disease (PD), incorporating the PD-protein PINK1 and rotenone, a toxin linked to PD. Using it as a drug-screening platform, they identify trifluoperazine and other piperazine phenothiazines as protective compounds that enhance autophagy independent of PINK1.
Copyright © 2017 Elsevier Ltd. All rights reserved.

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Year:  2017        PMID： 28431223      PMCID： PMC5845914          DOI： 10.1016/j.chembiol.2017.04.002

Source DB:  PubMed          Journal:  Cell Chem Biol        ISSN： 2451-9448            Impact factor:   8.116


  13 in total

1.  A neo-substrate that amplifies catalytic activity of parkinson's-disease-related kinase PINK1.

Authors:  Nicholas T Hertz; Amandine Berthet; Martin L Sos; Kurt S Thorn; Al L Burlingame; Ken Nakamura; Kevan M Shokat
Journal:  Cell       Date:  2013-08-15       Impact factor: 41.582

2.  PINK1 loss-of-function mutations affect mitochondrial complex I activity via NdufA10 ubiquinone uncoupling.

Authors:  Vanessa A Morais; Dominik Haddad; Katleen Craessaerts; Pieter-Jan De Bock; Jef Swerts; Sven Vilain; Liesbeth Aerts; Lut Overbergh; Anne Grünewald; Philip Seibler; Christine Klein; Kris Gevaert; Patrik Verstreken; Bart De Strooper
Journal:  Science       Date:  2014-03-20       Impact factor: 47.728

3.  Rescue of Pink1 Deficiency by Stress-Dependent Activation of Autophagy.

Authors:  Yuxi Zhang; David T Nguyen; Ellen M Olzomer; Gin P Poon; Nicholas J Cole; Anita Puvanendran; Brigitte R Phillips; Daniel Hesselson
Journal:  Cell Chem Biol       Date:  2017-03-30       Impact factor: 8.116

4.  A small-molecule scaffold induces autophagy in primary neurons and protects against toxicity in a Huntington disease model.

Authors:  Andrey S Tsvetkov; Jason Miller; Montserrat Arrasate; Jinny S Wong; Michael A Pleiss; Steven Finkbeiner
Journal:  Proc Natl Acad Sci U S A       Date:  2010-09-10       Impact factor: 11.205

5.  A highly reproducible rotenone model of Parkinson's disease.

Authors:  Jason R Cannon; Victor Tapias; Hye Mee Na; Anthony S Honick; Robert E Drolet; J Timothy Greenamyre
Journal:  Neurobiol Dis       Date:  2009-05       Impact factor: 5.996

6.  Rotenone, paraquat, and Parkinson's disease.

Authors:  Caroline M Tanner; Freya Kamel; G Webster Ross; Jane A Hoppin; Samuel M Goldman; Monica Korell; Connie Marras; Grace S Bhudhikanok; Meike Kasten; Anabel R Chade; Kathleen Comyns; Marie Barber Richards; Cheryl Meng; Benjamin Priestley; Hubert H Fernandez; Franca Cambi; David M Umbach; Aaron Blair; Dale P Sandler; J William Langston
Journal:  Environ Health Perspect       Date:  2011-01-26       Impact factor: 9.031

7.  Pharmacological exploitation of the phenothiazine antipsychotics to develop novel antitumor agents-A drug repurposing strategy.

Authors:  Chia-Hsien Wu; Li-Yuan Bai; Ming-Hsui Tsai; Po-Chen Chu; Chang-Fang Chiu; Michael Yuanchien Chen; Shih-Jiuan Chiu; Jo-Hua Chiang; Jing-Ru Weng
Journal:  Sci Rep       Date:  2016-06-09       Impact factor: 4.379

8.  Hereditary early-onset Parkinson's disease caused by mutations in PINK1.

Authors:  Enza Maria Valente; Patrick M Abou-Sleiman; Viviana Caputo; Miratul M K Muqit; Kirsten Harvey; Suzana Gispert; Zeeshan Ali; Domenico Del Turco; Anna Rita Bentivoglio; Daniel G Healy; Alberto Albanese; Robert Nussbaum; Rafael González-Maldonado; Thomas Deller; Sergio Salvi; Pietro Cortelli; William P Gilks; David S Latchman; Robert J Harvey; Bruno Dallapiccola; Georg Auburger; Nicholas W Wood
Journal:  Science       Date:  2004-04-15       Impact factor: 47.728

9.  TigarB causes mitochondrial dysfunction and neuronal loss in PINK1 deficiency.

Authors:  Laura J Flinn; Marcus Keatinge; Sandrine Bretaud; Heather Mortiboys; Hideaki Matsui; Elena De Felice; Helen I Woodroof; Lucy Brown; Aimee McTighe; Rosemarie Soellner; Claire E Allen; Paul R Heath; Marta Milo; Miratul M K Muqit; Andreas S Reichert; Reinhard W Köster; Philip W Ingham; Oliver Bandmann
Journal:  Ann Neurol       Date:  2013-12       Impact factor: 10.422

10.  Heterozygous PINK1 p.G411S increases risk of Parkinson's disease via a dominant-negative mechanism.

Authors:  Andreas Puschmann; Fabienne C Fiesel; Thomas R Caulfield; Roman Hudec; Maya Ando; Dominika Truban; Xu Hou; Kotaro Ogaki; Michael G Heckman; Elle D James; Maria Swanberg; Itzia Jimenez-Ferrer; Oskar Hansson; Grzegorz Opala; Joanna Siuda; Magdalena Boczarska-Jedynak; Andrzej Friedman; Dariusz Koziorowski; Monika Rudzińska-Bar; Jan O Aasly; Timothy Lynch; George D Mellick; Megha Mohan; Peter A Silburn; Yanosh Sanotsky; Carles Vilariño-Güell; Matthew J Farrer; Li Chen; Valina L Dawson; Ted M Dawson; Zbigniew K Wszolek; Owen A Ross; Wolfdieter Springer
Journal:  Brain       Date:  2016-11-02       Impact factor: 15.255
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  1 in total

1.  Integrating yeast chemical genomics and mammalian cell pathway analysis.

Authors:  Fu-Lai Zhou; Sheena C Li; Yue Zhu; Wan-Jing Guo; Li-Jun Shao; Justin Nelson; Scott Simpkins; De-Hua Yang; Qing Liu; Yoko Yashiroda; Jin-Biao Xu; Yao-Yue Fan; Jian-Min Yue; Minoru Yoshida; Tian Xia; Chad L Myers; Charles Boone; Ming-Wei Wang
Journal:  Acta Pharmacol Sin       Date:  2019-05-28       Impact factor: 6.150
  1 in total

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