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Literature DB >> 2842751

A knotted free minicircle in kinetoplast DNA.

K A Ryan¹, T A Shapiro, C A Rauch, J D Griffith, P T Englund.

Abstract

Kinetoplast DNA, the mitochondrial DNA of trypanosomes, is a network containing thousands of minicircles that are topologically interlocked. The minicircle replication intermediates are free molecules that have been released from the network. We report here that one form of free minicircles is a trefoil knot. Identification of this knotted structure is based on its electrophoretic and sedimentation properties, its response to treatments with restriction enzymes or topoisomerase II, and its appearance by electron microscopy. Except for its topology, the knotted minicircle closely resembles a previously described replication intermediate with a unique gap in the newly synthesized L strand.

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Year: 1988 PMID： 2842751 PMCID： PMC281861 DOI： 10.1073/pnas.85.16.5844

Source DB: PubMed Journal: Proc Natl Acad Sci U S A ISSN： 0027-8424 Impact factor: 11.205

24 in total

Review 1. Replication of kinetoplast DNA in trypanosomes.

Authors: K A Ryan; T A Shapiro; C A Rauch; P T Englund
Journal: Annu Rev Microbiol Date: 1988 Impact factor: 15.500

2. Presence of a bent helix in fragments of kinetoplast DNA minicircles from several trypanosomatid species.

Authors: J M Ntambi; J C Marini; J D Bangs; S L Hajduk; H E Jimenez; P A Kitchin; V A Klein; K A Ryan; P T Englund
Journal: Mol Biochem Parasitol Date: 1984-07 Impact factor: 1.759

Review 3. Kinetoplast DNA, mitochondrial DNA with a difference.

Authors: K Stuart
Journal: Mol Biochem Parasitol Date: 1983-10 Impact factor: 1.759

4. Genomic sequencing.

Authors: G M Church; W Gilbert
Journal: Proc Natl Acad Sci U S A Date: 1984-04 Impact factor: 11.205

5. A technique for radiolabeling DNA restriction endonuclease fragments to high specific activity.

Authors: A P Feinberg; B Vogelstein
Journal: Anal Biochem Date: 1983-07-01 Impact factor: 3.365

6. The making of strand-specific M13 probes.

Authors: N Hu; J Messing
Journal: Gene Date: 1982-03 Impact factor: 3.688

Review 7. The molecular biology of trypanosomes.

Authors: P T Englund; S L Hajduk; J C Marini
Journal: Annu Rev Biochem Date: 1982 Impact factor: 23.643

Review 8. Electron microscope visualization of chromatin and other DNA-protein complexes.

Authors: J D Griffith; G Christiansen
Journal: Annu Rev Biophys Bioeng Date: 1978

9. DNA topoisomerase II mutant of Saccharomyces cerevisiae: topoisomerase II is required for segregation of daughter molecules at the termination of DNA replication.

Authors: S DiNardo; K Voelkel; R Sternglanz
Journal: Proc Natl Acad Sci U S A Date: 1984-05 Impact factor: 11.205

10. Complete nucleotide sequence of minicircle kinetoplast DNA from Trypanosoma equiperdum.

Authors: M Barrois; G Riou; F Galibert
Journal: Proc Natl Acad Sci U S A Date: 1981-06 Impact factor: 11.205

12 in total

1. Novel display of knotted DNA molecules by two-dimensional gel electrophoresis.

Authors: S Trigueros; J Arsuaga; M E Vazquez; D W Sumners; J Roca
Journal: Nucleic Acids Res Date: 2001-07-01 Impact factor: 16.971

2. RNA interference of a trypanosome topoisomerase II causes progressive loss of mitochondrial DNA.

Authors: Z Wang; P T Englund
Journal: EMBO J Date: 2001-09-03 Impact factor: 11.598

3. A single-stranded DNA-binding protein from Crithidia fasciculata recognizes the nucleotide sequence at the origin of replication of kinetoplast DNA minicircles.

Authors: Y Tzfati; H Abeliovich; I Kapeller; J Shlomai
Journal: Proc Natl Acad Sci U S A Date: 1992-08-01 Impact factor: 11.205

A knotted free minicircle in kinetoplast DNA.

Review 1. Replication of kinetoplast DNA in trypanosomes.

2. Presence of a bent helix in fragments of kinetoplast DNA minicircles from several trypanosomatid species.

Review 3. Kinetoplast DNA, mitochondrial DNA with a difference.

4. Genomic sequencing.

5. A technique for radiolabeling DNA restriction endonuclease fragments to high specific activity.

6. The making of strand-specific M13 probes.

Review 7. The molecular biology of trypanosomes.

Review 8. Electron microscope visualization of chromatin and other DNA-protein complexes.

9. DNA topoisomerase II mutant of Saccharomyces cerevisiae: topoisomerase II is required for segregation of daughter molecules at the termination of DNA replication.

10. Complete nucleotide sequence of minicircle kinetoplast DNA from Trypanosoma equiperdum.

1. Novel display of knotted DNA molecules by two-dimensional gel electrophoresis.

2. RNA interference of a trypanosome topoisomerase II causes progressive loss of mitochondrial DNA.

3. A single-stranded DNA-binding protein from Crithidia fasciculata recognizes the nucleotide sequence at the origin of replication of kinetoplast DNA minicircles.

4. Role of p38 in replication of Trypanosoma brucei kinetoplast DNA.

5. A passion for parasites.

6. Synthesis and processing of kinetoplast DNA minicircles in Trypanosoma equiperdum.

7. Replication of DNA minicircles in kinetoplasts isolated from Crithidia fasciculata: structure of nascent minicircles.

8. A single-stranded DNA binding protein binds the origin of replication of the duplex kinetoplast DNA.

9. Mitochondrial topoisomerase II activity is essential for kinetoplast DNA minicircle segregation.

10. TbPIF5 is a Trypanosoma brucei mitochondrial DNA helicase involved in processing of minicircle Okazaki fragments.