Taylor M Etzel1, Antonia M Calafat2, Xiaoyun Ye2, Aimin Chen3, Bruce P Lanphear4, David A Savitz5, Kimberly Yolton6, Joseph M Braun5. 1. Department of Epidemiology, Brown University School of Public Health, Providence, RI, USA. Electronic address: Taylor_Etzel@brown.edu. 2. Division of Laboratory Sciences, National Center for Environmental Health, Centers for Disease Control and Prevention, Atlanta, GA, USA. 3. Department of Environmental Health, University of Cincinnati, College of Medicine, Cincinnati, OH, USA. 4. Faculty of Health Sciences, Simon Fraser University, Burnaby, B.C., Canada. 5. Department of Epidemiology, Brown University School of Public Health, Providence, RI, USA. 6. Division of General and Community Pediatrics, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.
Abstract
BACKGROUND: Triclosan is an antimicrobial chemical used in consumer products, and exposure is ubiquitous among pregnant women in the United States. Triclosan may reduce the levels of thyroid hormones that are important for fetal growth and development. OBJECTIVE: We investigated the relationship of prenatal triclosan exposure with birth anthropometry and gestational duration. METHODS: We used data from 378 mother-child pairs participating in the Health Outcomes and Measures of the Environment (HOME) Study, a prospective pregnancy and birth cohort from Cincinnati, OH. We measured triclosan concentrations in maternal urine samples collected at 16 and 26 weeks of pregnancy. We abstracted information on neonatal anthropometry and gestational duration from medical records. We used multivariable linear regression to estimate the covariate-adjusted association between the average of the two urinary triclosan concentrations and gestational age standardized weight z-score, length, head circumference, and gestational age at birth. RESULTS: Median urinary triclosan concentrations were 16ng/mL (range: <2.4 to 1501ng/mL). Each 10-fold increase in triclosan was associated with a predicted 0.15 standard deviation decrease (95% CI: -0.30, 0.00) in birth weight z-score, 0.4-cm decrease (95% CI: -0.8, 0.1) in birth length, 0.3-cm decrease (95% CI: -0.5, 0.0) in head circumference, and 0.3-week decrease (95% CI: -0.6, -0.1) in gestational age. Child sex did not modify the associations between triclosan and birth outcomes. CONCLUSIONS: In this cohort, maternal urinary triclosan concentrations during pregnancy were inversely associated with infants' birth weight, length, head circumference, and gestational age.
BACKGROUND:Triclosan is an antimicrobial chemical used in consumer products, and exposure is ubiquitous among pregnant women in the United States. Triclosan may reduce the levels of thyroid hormones that are important for fetal growth and development. OBJECTIVE: We investigated the relationship of prenatal triclosan exposure with birth anthropometry and gestational duration. METHODS: We used data from 378 mother-child pairs participating in the Health Outcomes and Measures of the Environment (HOME) Study, a prospective pregnancy and birth cohort from Cincinnati, OH. We measured triclosan concentrations in maternal urine samples collected at 16 and 26 weeks of pregnancy. We abstracted information on neonatal anthropometry and gestational duration from medical records. We used multivariable linear regression to estimate the covariate-adjusted association between the average of the two urinary triclosan concentrations and gestational age standardized weight z-score, length, head circumference, and gestational age at birth. RESULTS: Median urinary triclosan concentrations were 16ng/mL (range: <2.4 to 1501ng/mL). Each 10-fold increase in triclosan was associated with a predicted 0.15 standard deviation decrease (95% CI: -0.30, 0.00) in birth weight z-score, 0.4-cm decrease (95% CI: -0.8, 0.1) in birth length, 0.3-cm decrease (95% CI: -0.5, 0.0) in head circumference, and 0.3-week decrease (95% CI: -0.6, -0.1) in gestational age. Child sex did not modify the associations between triclosan and birth outcomes. CONCLUSIONS: In this cohort, maternal urinary triclosan concentrations during pregnancy were inversely associated with infants' birth weight, length, head circumference, and gestational age.
Authors: Joseph M Braun; Geetika Kalloo; Aimin Chen; Kim N Dietrich; Stacey Liddy-Hicks; Samantha Morgan; Yingying Xu; Kimberly Yolton; Bruce P Lanphear Journal: Int J Epidemiol Date: 2017-02-01 Impact factor: 7.196
Authors: Akhgar Ghassabian; Jacoba J Bongers-Schokking; Jens Henrichs; Vincent W V Jaddoe; Theo J Visser; Willy Visser; Sabine M P F de Muinck Keizer-Schrama; Herbert Hooijkaas; Eric A P Steegers; Albert Hofman; Frank C Verhulst; Jan van der Ende; Yolanda B de Rijke; Henning Tiemeier Journal: Pediatr Res Date: 2011-05 Impact factor: 3.756
Authors: Randi J Bertelsen; Stephanie M Engel; Todd A Jusko; Antonia M Calafat; Jane A Hoppin; Stephanie J London; Merete Eggesbø; Heidi Aase; Pål Zeiner; Ted Reichborn-Kjennerud; Gun P Knudsen; Virginia T Guidry; Matthew P Longnecker Journal: J Expo Sci Environ Epidemiol Date: 2014-01-29 Impact factor: 5.563
Authors: Mary S Wolff; Stephanie M Engel; Gertrud S Berkowitz; Xiaoyun Ye; Manori J Silva; Chenbo Zhu; James Wetmur; Antonia M Calafat Journal: Environ Health Perspect Date: 2008-08 Impact factor: 9.031
Authors: Amira M Aker; Kelly K Ferguson; Zaira Y Rosario; Bhramar Mukherjee; Akram N Alshawabkeh; José F Cordero; John D Meeker Journal: Environ Res Date: 2018-10-31 Impact factor: 6.498
Authors: Taylor Etzel; Gina Muckle; Tye E Arbuckle; William D Fraser; Emmanuel Ouellet; Jean R Séguin; Bruce Lanphear; Joseph M Braun Journal: Environ Int Date: 2018-03-02 Impact factor: 9.621
Authors: Suraj Sangroula; Alan Y Baez Vasquez; Prakash Raut; Bright Obeng; Juyoung K Shim; Grace D Bagley; Bailey E West; John E Burnell; Marissa S Kinney; Christian M Potts; Sasha R Weller; Joshua B Kelley; Samuel T Hess; Julie A Gosse Journal: Toxicol Appl Pharmacol Date: 2020-08-21 Impact factor: 4.219
Authors: Carmen Messerlian; Vicente Mustieles; Lidia Minguez-Alarcon; Jennifer B Ford; Antonia M Calafat; Irene Souter; Paige L Williams; Russ Hauser Journal: Environ Int Date: 2018-02-22 Impact factor: 9.621
Authors: Liheng H Zhuang; Aimin Chen; Joseph M Braun; Bruce P Lanphear; Janice M Y Hu; Kimberly Yolton; Lawrence C McCandless Journal: Environ Epidemiol Date: 2021-06-08