Taylor Etzel1, Gina Muckle2, Tye E Arbuckle3, William D Fraser4, Emmanuel Ouellet5, Jean R Séguin6, Bruce Lanphear7, Joseph M Braun8. 1. Department of Epidemiology, Brown University School of Public Health, 121 South Main Street, Providence, RI 02920, USA. Electronic address: Taylor_etzel@alumni.brown.edu. 2. School of Psychology, Laval University, 1050, Chemin Sainte-Foy, Local JS1-26, Québec G1S 4L8, Canada. Electronic address: gina.muckle@crchudequebec.ulaval.ca. 3. Population Studies Division, Environmental Health Science and Research Bureau, Health Canada, 101 Tunney's Pasture Driveway, AL 0201A, Ottawa, ON K1A 0K9, Canada. Electronic address: Tye.Arbuckle@canada.ca. 4. CHU Sainte-Justine Research Center, Mother and Child University Hospital Center, 3207 Chemin de la Côte-Sainte-Catherine, Montréal, QC H3T, Canada; Centre for Research of CHUS, University of Sherbrooke, 12e Avenue Nord, Sherbrooke, QC J1H 5N4, Canada. Electronic address: william.fraser@umontreal.ca. 5. Quebec CHU Research Center, 11 Côte du Palais, Ville de Québec, QC G1R 2J6, Canada. Electronic address: Emmanuel.Ouellet@crchudequebec.ulaval.ca. 6. CHU Sainte-Justine Research Center, Mother and Child University Hospital Center, 3207 Chemin de la Côte-Sainte-Catherine, Montréal, QC H3T, Canada; Department of Psychiatry, 2900 Edouard Montpetit Blvd, Montreal, QC H3T 1J4, Canada. Electronic address: jean.seguin@umontreal.ca. 7. Faculty of Health Sciences, Simon Fraser University, 8888 University Drive, Burnaby, BC V5A 1S6, Canada. Electronic address: bpl3@sfu.ca. 8. Department of Epidemiology, Brown University School of Public Health, 121 South Main Street, Providence, RI 02920, USA. Electronic address: joseph_braun_1@brown.edu.
Abstract
BACKGROUND: Exposure to triclosan, an antimicrobial chemical, is ubiquitous among pregnant women and may reduce thyroid hormone levels that are important for fetal neurodevelopment. Few studies have examined the association between prenatal triclosan exposure and children's neurobehavior. OBJECTIVE: We investigated the relationship of prenatal urinary triclosan concentrations with children's behavior and cognitive abilities at age three years in a prospective pregnancy and birth cohort in Canada. METHODS: We measured triclosan in urine samples collected at ~12 weeks of gestation in 794 Canadian women enrolled in a prospective pregnancy and birth cohort study (MIREC) from 2008 to 2011. Around age 3 years, we assessed children's cognitive abilities using the Wechsler Primary and Preschool Scale of Intelligence-III (WPPSI-III), and two scales of the Behavior Rating Inventory of Executive Function-Preschool (BRIEF-P). Parents reported children's problem and reciprocal social behaviors using the Behavior Assessment System for Children-2 (BASC-2) and Social Responsiveness Scale-2 (SRS-2), respectively. RESULTS: After adjusting for confounders using multivariable linear regression, triclosan was not associated with most of the 30 examined neurobehavioral scales. Each 10-fold increase in triclosan was associated with better WPPSI-III picture completion scores (β: 0.2; 95% CI: 0,0.5) and BASC-2 externalizing (β: -0.5; 95% CI: -1.1, 0) and hyperactivity (β: -0.6; 95% CI: -1.2, -0.1) scores, suggesting less externalizing and hyperactive behaviors. Child sex did not modify these associations. CONCLUSIONS: In this cohort, urinary triclosan concentrations measured once in early pregnancy were not associated with most assessed aspects of neurobehavior and weakly associated with a few others, but not in the hypothesized direction. Crown
BACKGROUND: Exposure to triclosan, an antimicrobial chemical, is ubiquitous among pregnant women and may reduce thyroid hormone levels that are important for fetal neurodevelopment. Few studies have examined the association between prenatal triclosan exposure and children's neurobehavior. OBJECTIVE: We investigated the relationship of prenatal urinary triclosan concentrations with children's behavior and cognitive abilities at age three years in a prospective pregnancy and birth cohort in Canada. METHODS: We measured triclosan in urine samples collected at ~12 weeks of gestation in 794 Canadian women enrolled in a prospective pregnancy and birth cohort study (MIREC) from 2008 to 2011. Around age 3 years, we assessed children's cognitive abilities using the Wechsler Primary and Preschool Scale of Intelligence-III (WPPSI-III), and two scales of the Behavior Rating Inventory of Executive Function-Preschool (BRIEF-P). Parents reported children's problem and reciprocal social behaviors using the Behavior Assessment System for Children-2 (BASC-2) and Social Responsiveness Scale-2 (SRS-2), respectively. RESULTS: After adjusting for confounders using multivariable linear regression, triclosan was not associated with most of the 30 examined neurobehavioral scales. Each 10-fold increase in triclosan was associated with better WPPSI-III picture completion scores (β: 0.2; 95% CI: 0,0.5) and BASC-2 externalizing (β: -0.5; 95% CI: -1.1, 0) and hyperactivity (β: -0.6; 95% CI: -1.2, -0.1) scores, suggesting less externalizing and hyperactive behaviors. Child sex did not modify these associations. CONCLUSIONS: In this cohort, urinary triclosan concentrations measured once in early pregnancy were not associated with most assessed aspects of neurobehavior and weakly associated with a few others, but not in the hypothesized direction. Crown
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