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Literature DB >> 28419680

BOLD neurovascular coupling does not change significantly with normal aging.

Jack Grinband¹, Jason Steffener², Qolamreza R Razlighi^3,4, Yaakov Stern³.

Abstract

Studies of cognitive function that compare the blood oxygenation level dependent (BOLD) signal across age groups often require the assumption that neurovascular coupling does not change with age. Tests of this assumption have produced mixed results regarding the strength of the coupling and its relative time course. Using deconvolution, we found that age does not have a significant effect on the time course of the hemodynamic impulse response function or on the slope of the BOLD versus stimulus duration relationship. These results suggest that in cognitive studies of healthy aging, group differences in BOLD activation are likely due to age-related changes in cognitive-neural interactions and information processing rather than to impairments in neurovascular coupling. Hum Brain Mapp 38:3538-3551, 2017.

Entities: Chemical Disease Gene Species

Keywords: BOLD; HRF; aging; hemodynamic response function

Year: 2017 PMID： 28419680 PMCID： PMC5882590 DOI： 10.1002/hbm.23608

Source DB: PubMed Journal: Hum Brain Mapp ISSN： 1065-9471 Impact factor: 5.038

103 in total

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6. Evidence for a refractory period in the hemodynamic response to visual stimuli as measured by MRI.

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Authors: A Berardi; R Parasuraman; J V Haxby
Journal: Exp Aging Res Date: 2001 Jan-Mar Impact factor: 1.645

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Authors: G H Glover
Journal: Neuroimage Date: 1999-04 Impact factor: 6.556

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Authors: S Kastner; M A Pinsk; P De Weerd; R Desimone; L G Ungerleider
Journal: Neuron Date: 1999-04 Impact factor: 17.173

10. Comparison of the hemodynamic response to different visual stimuli in single-event and block stimulation fMRI experiments.

Authors: C Janz; C Schmitt; O Speck; J Hennig
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Authors: Jason S Nomi; Taylor S Bolt; C E Chiemeka Ezie; Lucina Q Uddin; Aaron S Heller
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2. Tracking Age Differences in Neural Distinctiveness across Representational Levels.

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3. Failure to engage the temporoparietal junction/posterior superior temporal sulcus predicts impaired naturalistic social cognition in schizophrenia.

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Review 4. Vascular and haemodynamic issues of brain ageing.

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5. Reconfiguration of Directed Functional Connectivity Among Neurocognitive Networks with Aging: Considering the Role of Thalamo-Cortical Interactions.

Authors: Moumita Das; Vanshika Singh; Lucina Q Uddin; Arpan Banerjee; Dipanjan Roy
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Review 6. Cerebrovascular plasticity: Processes that lead to changes in the architecture of brain microvessels.

Authors: Max I Bogorad; Jackson G DeStefano; Raleigh M Linville; Andrew D Wong; Peter C Searson
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