Literature DB >> 28404735

Pathophysiology of Aortic Valve Stenosis: Is It Both Fibrocalcific and Sex Specific?

Yoginee Sritharen1, Maurice Enriquez-Sarano2, Hartzell V Schaff1, Grace Casaclang-Verzosa1,3, Jordan D Miller4,3,5,6.   

Abstract

Our understanding of the fundamental biology and identification of efficacious therapeutic targets in aortic valve stenosis has lagged far behind the fields of atherosclerosis and heart failure. In this review, we highlight the most clinically relevant problems facing men and women with fibrocalcific aortic valve stenosis, discuss the fundamental biology underlying valve calcification and fibrosis, and identify key molecular points of intersection with sex hormone signaling.
Copyright © 2017 Int. Union Physiol. Sci./Am. Physiol. Soc.

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Year:  2017        PMID： 28404735      PMCID： PMC6148342          DOI： 10.1152/physiol.00025.2016

Source DB:  PubMed          Journal:  Physiology (Bethesda)        ISSN： 1548-9221


  191 in total

1.  Transcriptional and phenotypic changes in aorta and aortic valve with aging and MnSOD deficiency in mice.

Authors:  Carolyn M Roos; Michael Hagler; Bin Zhang; Elise A Oehler; Arman Arghami; Jordan D Miller
Journal:  Am J Physiol Heart Circ Physiol       Date:  2013-08-30       Impact factor: 4.733

2.  Estrogen receptor beta protects the murine heart against left ventricular hypertrophy.

Authors:  Fawzi A Babiker; Daniel Lips; Rainer Meyer; Els Delvaux; Pieter Zandberg; Ben Janssen; Guillaume van Eys; Christian Grohé; Pieter A Doevendans
Journal:  Arterioscler Thromb Vasc Biol       Date:  2006-04-20       Impact factor: 8.311

Review 3.  Vascular calcification: pathobiology of a multifaceted disease.

Authors:  Linda L Demer; Yin Tintut
Journal:  Circulation       Date:  2008-06-03       Impact factor: 29.690

Review 4.  Osteogenic regulation of vascular calcification: an early perspective.

Authors:  Radhika Vattikuti; Dwight A Towler
Journal:  Am J Physiol Endocrinol Metab       Date:  2004-05       Impact factor: 4.310

5.  Impact of chamber geometry and gender on left ventricular systolic function in patients > 60 years of age with aortic stenosis.

Authors:  G P Aurigemma; K H Silver; M McLaughlin; J Mauser; W H Gaasch
Journal:  Am J Cardiol       Date:  1994-10-15       Impact factor: 2.778

6.  Estradiol inhibits GSK3 and regulates interaction of estrogen receptors, GSK3, and beta-catenin in the hippocampus.

Authors:  P Cardona-Gomez; M Perez; J Avila; L M Garcia-Segura; F Wandosell
Journal:  Mol Cell Neurosci       Date:  2004-03       Impact factor: 4.314

7.  Mutation of the palmitoylation site of estrogen receptor α in vivo reveals tissue-specific roles for membrane versus nuclear actions.

Authors:  Marine Adlanmerini; Romain Solinhac; Anne Abot; Aurélie Fabre; Isabelle Raymond-Letron; Anne-Laure Guihot; Frédéric Boudou; Lucile Sautier; Emilie Vessières; Sung Hoon Kim; Philippe Lière; Coralie Fontaine; Andrée Krust; Pierre Chambon; John A Katzenellenbogen; Pierre Gourdy; Philip W Shaul; Daniel Henrion; Jean-François Arnal; Françoise Lenfant
Journal:  Proc Natl Acad Sci U S A       Date:  2013-12-26       Impact factor: 11.205

8.  On the physiologic role of beta-2 adrenoceptors in the human heart: in vitro and in vivo studies.

Authors:  S Motomura; H Reinhard-Zerkowski; A Daul; O E Brodde
Journal:  Am Heart J       Date:  1990-03       Impact factor: 4.749

Review 9.  Risk Stratification in Patients With Aortic Stenosis Using Novel Imaging Approaches.

Authors:  Calvin W L Chin; Tania A Pawade; David E Newby; Marc R Dweck
Journal:  Circ Cardiovasc Imaging       Date:  2015-08       Impact factor: 7.792

Review 10.  Aortic Stenosis, a Left Ventricular Disease: Insights from Advanced Imaging.

Authors:  Sveeta Badiani; Jet van Zalen; Thomas A Treibel; Sanjeev Bhattacharyya; James C Moon; Guy Lloyd
Journal:  Curr Cardiol Rep       Date:  2016-08       Impact factor: 2.931
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  17 in total

1.  Quantification of aortic valve area: comparison of different methods of echocardiography with 3-D scan of the excised valve.

Authors:  Samira Shirazi; Fatemeh Golmohammadi; Anahita Tavoosi; Mehrdad Salehi; Farnoosh Larti; Akram Sardari; Babak Geraiely; Mehrzad Rahmanian; Kianoush Saberi; Roya Sattarzadeh Badkoubeh
Journal:  Int J Cardiovasc Imaging       Date:  2020-10-01       Impact factor: 2.357

2.  Current themes in myocardial and coronary vascular aging.

Authors:  Amanda J LeBlanc; Natia Q Kelm; Monika George
Journal:  Curr Opin Physiol       Date:  2017-12-13

3.  Genes That Escape X Chromosome Inactivation Modulate Sex Differences in Valve Myofibroblasts.

Authors:  Brian A Aguado; Cierra J Walker; Joseph C Grim; Megan E Schroeder; Dilara Batan; Brandon J Vogt; Andrea Gonzalez Rodriguez; Jessica A Schwisow; Karen S Moulton; Robert M Weiss; Donald D Heistad; Leslie A Leinwand; Kristi S Anseth
Journal:  Circulation       Date:  2022-01-10       Impact factor: 29.690

4.  Biomarkers Associated With Aortic Valve Calcification: Should We Focus on Sex Specific Processes?

Authors:  Frederique E C M Peeters; Elton A M P Dudink; Bob Weijs; Larissa Fabritz; Winnie Chua; Bas L J H Kietselaer; Joachim E Wildberger; Steven J R Meex; Paulus Kirchhof; Harry J G M Crijns; Leon J Schurgers
Journal:  Front Cell Dev Biol       Date:  2020-07-10

Review 5.  Inflammatory and Biomechanical Drivers of Endothelial-Interstitial Interactions in Calcific Aortic Valve Disease.

Authors:  Katherine Driscoll; Alexander D Cruz; Jonathan T Butcher
Journal:  Circ Res       Date:  2021-04-29       Impact factor: 17.367

Review 6.  Unanswered Questions Regarding Sex and BMP/TGF-β Signaling.

Authors:  Tapan A Shah; Melissa B Rogers
Journal:  J Dev Biol       Date:  2018-06-16

7.  MG 53 Protein Protects Aortic Valve Interstitial Cells From Membrane Injury and Fibrocalcific Remodeling.

Authors:  T M Ayodele Adesanya; Melanie Russell; Ki Ho Park; Xinyu Zhou; Matthew A Sermersheim; Kristyn Gumpper; Sara N Koenig; Tao Tan; Bryan A Whitson; Paul M L Janssen; Joy Lincoln; Hua Zhu; Jianjie Ma
Journal:  J Am Heart Assoc       Date:  2019-02-19       Impact factor: 5.501

Review 8.  Dissecting Calcific Aortic Valve Disease-The Role, Etiology, and Drivers of Valvular Fibrosis.

Authors:  Petra Büttner; Lukas Feistner; Philipp Lurz; Holger Thiele; Joshua D Hutcheson; Florian Schlotter
Journal:  Front Cardiovasc Med       Date:  2021-05-10

9.  Artificial Intelligence Models Reveal Sex-Specific Gene Expression in Aortic Valve Calcification.

Authors:  Philip Sarajlic; Oscar Plunde; Anders Franco-Cereceda; Magnus Bäck
Journal:  JACC Basic Transl Sci       Date:  2021-04-14

10.  Effects of Altering Mitochondrial Antioxidant Capacity on Molecular and Phenotypic Drivers of Fibrocalcific Aortic Valve Stenosis.

Authors:  Carolyn M Roos; Bin Zhang; Michael A Hagler; Grace C Verzosa; Runqing Huang; Elise A Oehler; Arman Arghami; Jordan D Miller
Journal:  Front Cardiovasc Med       Date:  2021-06-24
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