Literature DB >> 28390874

Application of single-cell technology in cancer research.

Shao-Bo Liang1, Li-Wu Fu2.   

Abstract

In this review, we have outlined the application of single-cell technology in cancer research. Single-cell technology has made encouraging progress in recent years and now provides the means to detect rare cancer cells such as circulating tumor cells and cancer stem cells. We reveal how this technology has advanced the analysis of intratumor heterogeneity and tumor epigenetics, and guided individualized treatment strategies. The future prospects now are to bring single-cell technology into the clinical arena. We believe that the clinical application of single-cell technology will be beneficial in cancer diagnostics and treatment, and ultimately improve survival in cancer patients.
Copyright © 2017 The Authors. Published by Elsevier Inc. All rights reserved.

Entities:  

Keywords:  Individualized treatment; Intratumor heterogeneity; Rare tumor cells; Single-cell technology; Tumor epigenetics

Mesh:

Year:  2017        PMID: 28390874     DOI: 10.1016/j.biotechadv.2017.04.001

Source DB:  PubMed          Journal:  Biotechnol Adv        ISSN: 0734-9750            Impact factor:   14.227


  11 in total

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