Marcel Chehuen1, Gabriel G Cucato2, Celso Ricardo F Carvalho3, Raphael M Ritti-Dias2, Nelson Wolosker3, Anthony S Leicht4, Cláudia Lúcia M Forjaz5. 1. School of Physical Education and Sport, University of São Paulo, Brazil. Electronic address: marcel_chehuen@hotmail.com. 2. Albert Einstein Israelite Hospital, Brazil. 3. Hospital das Clínicas, University of São Paulo, Brazil. 4. College of Healthcare Sciences, James Cook University, Australia. 5. School of Physical Education and Sport, University of São Paulo, Brazil.
Abstract
OBJECTIVES: This study investigated the effects of walking training (WT) on cardiovascular function and autonomic regulation in patents with intermittent claudication (IC). DESIGN: Randomized controlled trial. METHODS:Forty-two male patients with IC (≥50years) were randomly allocated into two groups: control (CG, n=20, 30min of stretching exercises) and WT (WTG, n=22, 15 bouts of 2min of walking interpolated by 2min of upright rest-walking intensity was set at the heart rate of pain threshold). Both interventions were performed twice/week for 12 weeks. Walking capacity (maximal treadmill test), blood pressure (auscultatory), cardiac output (CO2 rebreathing), heart rate (ECG), stroke volume, systemic vascular resistance, forearm and calf vascular resistance (plethysmography), and low (LF) and high frequency (HF) components of heart rate variability and spontaneous baroreflex sensitivity were measured at baseline and after 12 weeks of the study. RESULTS: WT increased total walking distance (+302±85m, p=0.001) and spontaneous baroreflex sensitivity (+2.13±1.07ms/mmHg, p=0.02). Additionally, at rest, WT decreased systolic and mean blood pressures (-10±3 and -5±2mmHg, p=0.001 and p=0.01, respectively), cardiac output (-0.37±0.24l/min, p=0.03), heart rate (-4±2bpm, p=0.001), forearm vascular resistance (-8.5±2.8U, p=0.02) and LF/HF (-1.24±0.99, p=0.001). No change was observed in the CG. CONCLUSIONS: In addition to increasing walking capacity, WT improved cardiovascular function and autonomic regulation in patients with IC.
RCT Entities:
OBJECTIVES: This study investigated the effects of walking training (WT) on cardiovascular function and autonomic regulation in patents with intermittent claudication (IC). DESIGN: Randomized controlled trial. METHODS: Forty-two male patients with IC (≥50years) were randomly allocated into two groups: control (CG, n=20, 30min of stretching exercises) and WT (WTG, n=22, 15 bouts of 2min of walking interpolated by 2min of upright rest-walking intensity was set at the heart rate of pain threshold). Both interventions were performed twice/week for 12 weeks. Walking capacity (maximal treadmill test), blood pressure (auscultatory), cardiac output (CO2 rebreathing), heart rate (ECG), stroke volume, systemic vascular resistance, forearm and calf vascular resistance (plethysmography), and low (LF) and high frequency (HF) components of heart rate variability and spontaneous baroreflex sensitivity were measured at baseline and after 12 weeks of the study. RESULTS: WT increased total walking distance (+302±85m, p=0.001) and spontaneous baroreflex sensitivity (+2.13±1.07ms/mmHg, p=0.02). Additionally, at rest, WT decreased systolic and mean blood pressures (-10±3 and -5±2mmHg, p=0.001 and p=0.01, respectively), cardiac output (-0.37±0.24l/min, p=0.03), heart rate (-4±2bpm, p=0.001), forearm vascular resistance (-8.5±2.8U, p=0.02) and LF/HF (-1.24±0.99, p=0.001). No change was observed in the CG. CONCLUSIONS: In addition to increasing walking capacity, WT improved cardiovascular function and autonomic regulation in patients with IC.
Authors: Luciana Ragazzo; Pedro Puech-Leao; Nelson Wolosker; Nelson de Luccia; Glauco Saes; Raphael M Ritti-Dias; Gabriel Grizzo Cucato; Debora Yumi Ferreira Kamikava; Antonio Eduardo Zerati Journal: Clinics (Sao Paulo) Date: 2021-01-20 Impact factor: 2.365
Authors: Marilia A Correia; Paulo L Oliveira; Breno Q Farah; Lauro C Vianna; Nelson Wolosker; Pedro Puech-Leao; Daniel J Green; Gabriel G Cucato; Raphael M Ritti-Dias Journal: J Am Heart Assoc Date: 2020-02-06 Impact factor: 5.501