| Literature DB >> 28384471 |
Bryce A Mander1, Joseph R Winer1, Matthew P Walker2.
Abstract
Older adults do not sleep as well as younger adults. Why? What alterations in sleep quantity and quality occur as we age, and are there functional consequences? What are the underlying neural mechanisms that explain age-related sleep disruption? This review tackles these questions. First, we describe canonical changes in human sleep quantity and quality in cognitively normal older adults. Second, we explore the underlying neurobiological mechanisms that may account for these human sleep alterations. Third, we consider the functional consequences of age-related sleep disruption, focusing on memory impairment as an exemplar. We conclude with a discussion of a still-debated question: do older adults simply need less sleep, or rather, are they unable to generate the sleep that they still need?Entities:
Keywords: Alzheimer’s disease; aging; brain stimulation; dementia; memory; non-rapid eye movement sleep; rapid eye movement sleep; sleep; sleep spindles; slow waves
Mesh：
Year: 2017 PMID： 28384471 PMCID： PMC5810920 DOI： 10.1016/j.neuron.2017.02.004
Source DB: PubMed Journal: Neuron ISSN： 0896-6273 Impact factor: 17.173