Literature DB >> 3992248

A sexually dimorphic nucleus in the human brain.

D F Swaab, E Fliers.   

Abstract

A sexually dimorphic cell group is described in the preoptic area of the human hypothalamus. Morphometric analysis revealed that the volume of this nucleus is 2.5 +/- 0.6 times (mean +/- standard error of the mean) as large in men as in women, and contains 2.2 +/- 0.5 times as many cells. Between the ages of 10 and 93 years, the nucleus decreases greatly in volume and in cell number. Although no function has yet been established for this nucleus, it is located within an area that is essential for gonadotropin release and sexual behavior in other mammals.

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Year:  1985        PMID: 3992248     DOI: 10.1126/science.3992248

Source DB:  PubMed          Journal:  Science        ISSN: 0036-8075            Impact factor:   47.728


  59 in total

1.  Sex-related differences in the cell cycle parameters of the ventricular zone in the developing preoptic area of rat embryos.

Authors:  V K Chetverukhin; E V Chernigovskaya; O A Danilova
Journal:  Dokl Biol Sci       Date:  2002 Jul-Aug

2.  Neuron numbers in the hypothalamus of the normal aging rhesus monkey: stability across the adult lifespan and between the sexes.

Authors:  D E Roberts; R J Killiany; D L Rosene
Journal:  J Comp Neurol       Date:  2012-04-15       Impact factor: 3.215

3.  Morphometric analysis of the supraoptic nucleus in the human brain.

Authors:  M A Hofman; E Goudsmit; J S Purba; D F Swaab
Journal:  J Anat       Date:  1990-10       Impact factor: 2.610

Review 4.  Ethical implications of scientific research on the causes of sexual orientation.

Authors:  W Byne; E Stein
Journal:  Health Care Anal       Date:  1997-06

5.  Gender and age differences in normal adult human brain: voxel-based morphometric study.

Authors:  Ryuichi Takahashi; Kazunari Ishii; Tatsuya Kakigi; Kazumasa Yokoyama
Journal:  Hum Brain Mapp       Date:  2010-07-06       Impact factor: 5.038

Review 6.  Developmental programming and endocrine disruptor effects on reproductive neuroendocrine systems.

Authors:  Andrea C Gore
Journal:  Front Neuroendocrinol       Date:  2008-03-05       Impact factor: 8.606

7.  Gender differences in pain perception and patterns of cerebral activation during noxious heat stimulation in humans.

Authors:  P E Paulson; S Minoshima; T J Morrow; K L Casey
Journal:  Pain       Date:  1998-05       Impact factor: 6.961

Review 8.  Development of the human hypothalamus.

Authors:  D F Swaab
Journal:  Neurochem Res       Date:  1995-05       Impact factor: 3.996

Review 9.  Sex differences in the brain: the relation between structure and function.

Authors:  Geert J de Vries; Per Södersten
Journal:  Horm Behav       Date:  2009-05       Impact factor: 3.587

Review 10.  Interactions between age, sex, and hormones in experimental ischemic stroke.

Authors:  Fudong Liu; Louise D McCullough
Journal:  Neurochem Int       Date:  2012-10-13       Impact factor: 3.921

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