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Literature DB >> 28368286

Distinct but complementary contributions of PPAR isotypes to energy homeostasis.

Vanessa Dubois, Jérôme Eeckhoute, Philippe Lefebvre, Bart Staels.

Abstract

Peroxisome proliferator-activated receptors (PPARs) regulate energy metabolism and hence are therapeutic targets in metabolic diseases such as type 2 diabetes and non-alcoholic fatty liver disease. While they share anti-inflammatory activities, the PPAR isotypes distinguish themselves by differential actions on lipid and glucose homeostasis. In this Review we discuss the complementary and distinct metabolic effects of the PPAR isotypes together with the underlying cellular and molecular mechanisms, as well as the synthetic PPAR ligands that are used in the clinic or under development. We highlight the potential of new PPAR ligands with improved efficacy and safety profiles in the treatment of complex metabolic disorders.

Entities: Chemical Disease Gene

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Year: 2017 PMID： 28368286 PMCID： PMC5373878 DOI： 10.1172/JCI88894

Source DB: PubMed Journal: J Clin Invest ISSN： 0021-9738 Impact factor: 14.808

192 in total

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Journal: Diabetes Date: 2005-02 Impact factor: 9.461

2. Effect of fasting on PPARgamma and AMPK activity in adipocytes.

Authors: Kazuo Kajita; Tomoatsu Mune; Takahide Ikeda; Masami Matsumoto; Yoshihiro Uno; Chiyo Sugiyama; Kenji Matsubara; Hiroyuki Morita; Masao Takemura; Mitsuru Seishima; Jun Takeda; Tatsuo Ishizuka
Journal: Diabetes Res Clin Pract Date: 2008-06-17 Impact factor: 5.602

3. Activation of peroxisome proliferator-activated receptor delta induces fatty acid beta-oxidation in skeletal muscle and attenuates metabolic syndrome.

Authors: Toshiya Tanaka; Joji Yamamoto; Satoshi Iwasaki; Hiroshi Asaba; Hiroki Hamura; Yukio Ikeda; Mitsuhiro Watanabe; Kenta Magoori; Ryoichi X Ioka; Keisuke Tachibana; Yuichiro Watanabe; Yasutoshi Uchiyama; Koichi Sumi; Haruhisa Iguchi; Sadayoshi Ito; Takefumi Doi; Takao Hamakubo; Makoto Naito; Johan Auwerx; Masashi Yanagisawa; Tatsuhiko Kodama; Juro Sakai
Journal: Proc Natl Acad Sci U S A Date: 2003-12-15 Impact factor: 11.205

4. Peroxisome Proliferator-activated Receptor-γ Activation Augments the β-Cell Unfolded Protein Response and Rescues Early Glycemic Deterioration and β Cell Death in Non-obese Diabetic Mice.

Authors: Aarthi V Maganti; Sarah A Tersey; Farooq Syed; Jennifer B Nelson; Stephanie C Colvin; Bernhard Maier; Raghavendra G Mirmira
Journal: J Biol Chem Date: 2016-09-09 Impact factor: 5.157

5. Identification of a physiologically relevant endogenous ligand for PPARalpha in liver.

Authors: Manu V Chakravarthy; Irfan J Lodhi; Li Yin; Raghu R V Malapaka; H Eric Xu; John Turk; Clay F Semenkovich
Journal: Cell Date: 2009-07-30 Impact factor: 41.582

6. Apolipoprotein A5, a crucial determinant of plasma triglyceride levels, is highly responsive to peroxisome proliferator-activated receptor alpha activators.

Authors: Ngoc Vu-Dac; Philippe Gervois; Heidi Jakel; Maxime Nowak; Eric Bauge; Helene Dehondt; Bart Staels; Len A Pennacchio; Edward M Rubin; Jamila Fruchart-Najib; Jean-Charles Fruchart
Journal: J Biol Chem Date: 2003-03-12 Impact factor: 5.157

7. A multicenter, prospective, randomized, double-blind study to evaluate the safety and efficacy of Saroglitazar 2 and 4 mg compared with placebo in type 2 diabetes mellitus patients having hypertriglyceridemia not controlled with atorvastatin therapy (PRESS VI).

Authors: Rajendrakumar H Jani; Vikas Pai; Pramod Jha; Gunjan Jariwala; Satinath Mukhopadhyay; Anil Bhansali; Shashank Joshi
Journal: Diabetes Technol Ther Date: 2013-10-18 Impact factor: 6.118

8. Role of adipose triglyceride lipase (PNPLA2) in protection from hepatic inflammation in mouse models of steatohepatitis and endotoxemia.

Authors: Pooja Jha; Thierry Claudel; Anna Baghdasaryan; Michaela Mueller; Emina Halilbasic; Suman K Das; Achim Lass; Robert Zimmermann; Rudolf Zechner; Gerald Hoefler; Michael Trauner
Journal: Hepatology Date: 2014-01-28 Impact factor: 17.298

9. Nuclear receptor/microRNA circuitry links muscle fiber type to energy metabolism.

Authors: Zhenji Gan; John Rumsey; Bethany C Hazen; Ling Lai; Teresa C Leone; Rick B Vega; Hui Xie; Kevin E Conley; Johan Auwerx; Steven R Smith; Eric N Olson; Anastasia Kralli; Daniel P Kelly
Journal: J Clin Invest Date: 2013-05-08 Impact factor: 14.808

10. Dual peroxisome proliferator-activated receptor α/δ agonist GFT505 improves hepatic and peripheral insulin sensitivity in abdominally obese subjects.

Authors: Bertrand Cariou; Rémy Hanf; Stéphanie Lambert-Porcheron; Yassine Zaïr; Valérie Sauvinet; Benoit Noël; Laurent Flet; Hubert Vidal; Bart Staels; Martine Laville
Journal: Diabetes Care Date: 2013-05-28 Impact factor: 19.112

78 in total

Review 1. Nuclear receptor crosstalk - defining the mechanisms for therapeutic innovation.

Authors: Karolien De Bosscher; Sofie J Desmet; Dorien Clarisse; Eva Estébanez-Perpiña; Luc Brunsveld
Journal: Nat Rev Endocrinol Date: 2020-04-17 Impact factor: 43.330

2. The chromatin remodeler SRCAP promotes self-renewal of intestinal stem cells.

Authors: Buqing Ye; Liuliu Yang; Guomin Qian; Benyu Liu; Xiaoxiao Zhu; Pingping Zhu; Jing Ma; Wei Xie; Huimu Li; Tianku Lu; Yanying Wang; Shuo Wang; Ying Du; Zhimin Wang; Jing Jiang; Jinsong Li; Dongdong Fan; Shu Meng; Jiayi Wu; Yong Tian; Zusen Fan
Journal: EMBO J Date: 2020-05-25 Impact factor: 11.598

Review 3. Activation of the Metabolic Master Regulator PPARγ: A Potential PIOneering Therapy for Pulmonary Arterial Hypertension.

Authors: Georg Hansmann; Laurent Calvier; Michael G Risbano; Stephen Y Chan
Journal: Am J Respir Cell Mol Biol Date: 2020-02 Impact factor: 6.914

4. Discovery of peroxisome proliferator-activated receptor α (PPARα) activators with a ligand-screening system using a human PPARα-expressing cell line.

Authors: Keisuke Tachibana; Tomohiro Yuzuriha; Ryotaro Tabata; Syohei Fukuda; Takashi Maegawa; Rika Takahashi; Keiichi Tanimoto; Hirofumi Tsujino; Kazuto Nunomura; Bangzhong Lin; Yoshiharu Matsuura; Toshiya Tanaka; Takao Hamakubo; Juro Sakai; Tatsuhiko Kodama; Tadayuki Kobayashi; Kenji Ishimoto; Hiroyuki Miyachi; Takefumi Doi
Journal: J Biol Chem Date: 2018-05-15 Impact factor: 5.157

5. Interspecies NASH disease activity whole-genome profiling identifies a fibrogenic role of PPARα-regulated dermatopontin.

Authors: Philippe Lefebvre; Fanny Lalloyer; Eric Baugé; Michal Pawlak; Céline Gheeraert; Hélène Dehondt; Jonathan Vanhoutte; Eloise Woitrain; Nathalie Hennuyer; Claire Mazuy; Marie Bobowski-Gérard; Francesco Paolo Zummo; Bruno Derudas; Ann Driessen; Guy Hubens; Luisa Vonghia; Wilhelmus J Kwanten; Peter Michielsen; Thomas Vanwolleghem; Jérôme Eeckhoute; An Verrijken; Luc Van Gaal; Sven Francque; Bart Staels
Journal: JCI Insight Date: 2017-07-06

6. miR-30a targets gene networks that promote browning of human and mouse adipocytes.

Authors: Pradip K Saha; Mark P Hamilton; Kimal Rajapakshe; Vasanta Putluri; Jessica B Felix; Peter Masschelin; Aaron R Cox; Mandeep Bajaj; Nagireddy Putluri; Cristian Coarfa; Sean M Hartig
Journal: Am J Physiol Endocrinol Metab Date: 2020-08-17 Impact factor: 4.310

7. Hepatic PPARα is critical in the metabolic adaptation to sepsis.

Authors: Réjane Paumelle; Joel T Haas; Nathalie Hennuyer; Eric Baugé; Yann Deleye; Dieter Mesotten; Lies Langouche; Jonathan Vanhoutte; Céline Cudejko; Kristiaan Wouters; Sarah Anissa Hannou; Vanessa Legry; Steve Lancel; Fanny Lalloyer; Arnaud Polizzi; Sarra Smati; Pierre Gourdy; Emmanuelle Vallez; Emmanuel Bouchaert; Bruno Derudas; Hélène Dehondt; Céline Gheeraert; Sébastien Fleury; Anne Tailleux; Alexandra Montagner; Walter Wahli; Greet Van Den Berghe; Hervé Guillou; David Dombrowicz; Bart Staels
Journal: J Hepatol Date: 2019-01-21 Impact factor: 25.083

Review 8. Nonalcoholic Fatty Liver Disease.

Authors: Lingling Ding; Yvonne Oligschlaeger; Ronit Shiri-Sverdlov; Tom Houben
Journal: Handb Exp Pharmacol Date: 2022

Review 9. PPAR control of metabolism and cardiovascular functions.

Authors: David Montaigne; Laura Butruille; Bart Staels
Journal: Nat Rev Cardiol Date: 2021-06-14 Impact factor: 32.419

Review 10. The role of peroxisome proliferator-activated receptors (PPAR) in immune responses.

Authors: Anthos Christofides; Eirini Konstantinidou; Chinmay Jani; Vassiliki A Boussiotis
Journal: Metabolism Date: 2020-08-11 Impact factor: 8.694