Literature DB >> 32791172

The role of peroxisome proliferator-activated receptors (PPAR) in immune responses.

Anthos Christofides1, Eirini Konstantinidou1, Chinmay Jani2, Vassiliki A Boussiotis3.   

Abstract

Peroxisome proliferator-activated receptors (PPARs) are fatty acid-activated transcription factors of nuclear hormone receptor superfamily that regulate energy metabolism. Currently, three PPAR subtypes have been identified: PPARα, PPARγ, and PPARβ/δ. PPARα and PPARδ are highly expressed in oxidative tissues and regulate genes involved in substrate delivery and oxidative phosphorylation (OXPHOS) and regulation of energy homeostasis. In contrast, PPARγ is more important in lipogenesis and lipid synthesis, with highest expression levels in white adipose tissue (WAT). In addition to tissues regulating whole body energy homeostasis, PPARs are expressed in immune cells and have an emerging critical role in immune cell differentiation and fate commitment. In this review, we discuss the actions of PPARs in the function of the innate and the adaptive immune system and their implications in immune-mediated inflammatory conditions.
Copyright © 2020 Elsevier Inc. All rights reserved.

Entities:  

Keywords:  Inflammation; Metabolism; Myeloid cells; PPAR; T cells

Mesh：

Substances：

Year:  2020        PMID： 32791172      PMCID： PMC7736084          DOI： 10.1016/j.metabol.2020.154338

Source DB:  PubMed          Journal:  Metabolism        ISSN： 0026-0495            Impact factor:   8.694


  187 in total

1.  Induction of the nuclear receptor PPAR-γ by the cytokine GM-CSF is critical for the differentiation of fetal monocytes into alveolar macrophages.

Authors:  Christoph Schneider; Samuel P Nobs; Michael Kurrer; Hubert Rehrauer; Christoph Thiele; Manfred Kopf
Journal:  Nat Immunol       Date:  2014-09-28       Impact factor: 25.606

2.  The role of PPAR-gamma in macrophage differentiation and cholesterol uptake.

Authors:  K J Moore; E D Rosen; M L Fitzgerald; F Randow; L P Andersson; D Altshuler; D S Milstone; R M Mortensen; B M Spiegelman; M W Freeman
Journal:  Nat Med       Date:  2001-01       Impact factor: 53.440

3.  Coordination Among Lipid Droplets, Peroxisomes, and Mitochondria Regulates Energy Expenditure Through the CIDE-ATGL-PPARα Pathway in Adipocytes.

Authors:  Linkang Zhou; Miao Yu; Muhammad Arshad; Wenmin Wang; Ye Lu; Jingyi Gong; Yangnan Gu; Peng Li; Li Xu
Journal:  Diabetes       Date:  2018-07-09       Impact factor: 9.461

4.  Modulation of the Inflammatory Status of Macrophages and Their Paracrine Effect on the Sensitivity of Adipocytes to Insulin with Sirtuin and PPARγ Receptor Activators.

Authors:  Yu S Stafeev; S S Michurina; E S Zubkova; I B Beloglazova; E I Ratner; E V Parfenova; M Yu Men'shikov
Journal:  Bull Exp Biol Med       Date:  2018-08-18       Impact factor: 0.804

Review 5.  Transcriptional regulation of metabolism.

Authors:  Béatrice Desvergne; Liliane Michalik; Walter Wahli
Journal:  Physiol Rev       Date:  2006-04       Impact factor: 37.312

6.  Peroxisome proliferator-activated receptor activators inhibit lipopolysaccharide-induced tumor necrosis factor-alpha expression in neonatal rat cardiac myocytes.

Authors:  H Takano; T Nagai; M Asakawa; T Toyozaki; T Oka; I Komuro; T Saito; Y Masuda
Journal:  Circ Res       Date:  2000-09-29       Impact factor: 17.367

7.  Topical rosiglitazone treatment improves ulcerative colitis by restoring peroxisome proliferator-activated receptor-gamma activity.

Authors:  Gitte Pedersen; Jørn Brynskov
Journal:  Am J Gastroenterol       Date:  2010-01-19       Impact factor: 10.864

8.  PPARs: Nuclear Receptors Controlled by, and Controlling, Nutrient Handling through Nuclear and Cytosolic Signaling.

Authors:  Maria Moreno; Assunta Lombardi; Elena Silvestri; Rosalba Senese; Federica Cioffi; Fernando Goglia; Antonia Lanni; Pieter de Lange
Journal:  PPAR Res       Date:  2010-08-01       Impact factor: 4.964

9.  INT131: a selective modulator of PPAR gamma.

Authors:  Alykhan Motani; Zhulun Wang; Jennifer Weiszmann; Lawrence R McGee; Gary Lee; Qingxiang Liu; Jocelyn Staunton; Zexu Fang; Helen Fuentes; Michelle Lindstrom; Jinsong Liu; Donna H T Biermann; Juan Jaen; Nigel P C Walker; R Marc Learned; Jin-Long Chen; Yang Li
Journal:  J Mol Biol       Date:  2009-03-13       Impact factor: 5.469

10.  Raising plasma fatty acid concentration induces increased biogenesis of mitochondria in skeletal muscle.

Authors:  Pablo Garcia-Roves; Janice M Huss; Dong-Ho Han; Chad R Hancock; Eduardo Iglesias-Gutierrez; May Chen; John O Holloszy
Journal:  Proc Natl Acad Sci U S A       Date:  2007-06-04       Impact factor: 11.205
View more
  34 in total

1.  Molecular mechanisms of aberrant neutrophil differentiation in glycogen storage disease type Ib.

Authors:  Sang Wan Sim; Yuyeon Jang; Tae Sub Park; Byung-Chul Park; Young Mok Lee; Hyun Sik Jun
Journal:  Cell Mol Life Sci       Date:  2022-04-18       Impact factor: 9.261

Review 2.  The complex role of tumor-infiltrating macrophages.

Authors:  Anthos Christofides; Laura Strauss; Alan Yeo; Carol Cao; Alain Charest; Vassiliki A Boussiotis
Journal:  Nat Immunol       Date:  2022-07-25       Impact factor: 31.250

Review 3.  Mechanisms of Myocardial Damage Due to Hyperlipidemia: A Review of Recent Studies.

Authors:  Zhiqi Zhang; Hongyi Wu; Tao Wang; Yao Liu; Chun Meng
Journal:  Med Sci Monit       Date:  2022-09-16

Review 4.  Effect of cell receptors in the pathogenesis of osteoarthritis: Current insights.

Authors:  Li Lei; Li Meng; Xu Changqing; Zhu Chen; Yao Gang; Fang Shiyuan
Journal:  Open Life Sci       Date:  2022-07-07       Impact factor: 1.311

5.  PPAR-α Agonist Fenofibrate Ameliorates Sjögren Syndrome-Like Dacryoadenitis by Modulating Th1/Th17 and Treg Cell Responses in NOD Mice.

Authors:  Xingyi Guo; Weiyu Dang; Na Li; Ying Wang; Deming Sun; Hong Nian; Ruihua Wei
Journal:  Invest Ophthalmol Vis Sci       Date:  2022-06-01       Impact factor: 4.925

Review 6.  PPARs and Tumor Microenvironment: The Emerging Roles of the Metabolic Master Regulators in Tumor Stromal-Epithelial Crosstalk and Carcinogenesis.

Authors:  Hong Sheng Cheng; Yun Sheng Yip; Eldeen Kai Yi Lim; Walter Wahli; Nguan Soon Tan
Journal:  Cancers (Basel)       Date:  2021-04-29       Impact factor: 6.639

7.  Comorbid anxiety-like behavior in a rat model of colitis is mediated by an upregulation of corticolimbic fatty acid amide hydrolase.

Authors:  Haley A Vecchiarelli; Maria Morena; Catherine M Keenan; Vincent Chiang; Kaitlyn Tan; Min Qiao; Kira Leitl; Alessia Santori; Quentin J Pittman; Keith A Sharkey; Matthew N Hill
Journal:  Neuropsychopharmacology       Date:  2021-01-15       Impact factor: 7.853

8.  Intestinal Transcriptome Analysis Reveals Enrichment of Genes Associated with Immune and Lipid Mechanisms, Favoring Soybean Meal Tolerance in High-Growth Zebrafish (Danio Rerio).

Authors:  Luis Valenzuela; Sebastian Pacheco; Gonzalo Rincón; Leonardo Pavez; Natalia Lam; Adrián J Hernández; Patricio Dantagnan; Felipe González; Felipe Jilberto; M Cristina Ravanal; Cecilia Ramos; Héctor Garcia; Cristian Araneda; Pilar E Ulloa
Journal:  Genes (Basel)       Date:  2021-05-08       Impact factor: 4.096

Review 9.  The Agonists of Peroxisome Proliferator-Activated Receptor-γ for Liver Fibrosis.

Authors:  Jingjing Li; Chuanyong Guo; Jianye Wu
Journal:  Drug Des Devel Ther       Date:  2021-06-18       Impact factor: 4.162

10.  Propofol ameliorates renal ischemia/reperfusion injury by enhancing macrophage M2 polarization through PPARγ/STAT3 signaling.

Authors:  Zhaohui Liu; Yanli Meng; Yu Miao; Lili Yu; Qianjie Wei; Yuqing Li; Bing Zhang; Qiannan Yu
Journal:  Aging (Albany NY)       Date:  2021-06-10       Impact factor: 5.682
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.