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Literature DB >> 2836631

A 67-base-pair segment from the Ori-S region of herpes simplex virus type 1 encodes origin function.

Abstract

The Ori-S segment of herpes simplex virus type 1 contains a 45-base-pair-long imperfect palindrome with an AT segment at its center. We cloned Ori-S into a poisonless plasmid to investigate the role of the palindromic components in DNA replication. Neither a large insertion within the AT segment nor a deletion of the right side of the palindrome significantly inhibited DNA replication under our conditions of analysis. These findings argue against the necessity for a specific cruciform structure in the initiation of replication. We scanned the entire AT segment with triple tandem-base-pair substitutions to pinpoint essential functional sequences. Only the first 3 base pairs at the left end of the segment are absolutely essential for replication in the presence of the remaining AT sequences.

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Year: 1988 PMID： 2836631 PMCID： PMC253414 DOI： 10.1128/JVI.62.7.2516-2519.1988

Source DB: PubMed Journal: J Virol ISSN： 0022-538X Impact factor: 5.103

27 in total

1. THE MULTIPLICATION OF HERPES SIMPLEX VIRUS. II. THE RELATION BETWEEN PROTEIN SYNTHESIS AND THE DUPLICATION OF VIRAL DNA IN INFECTED HEP-2 CELLS.

Authors: B ROIZMAN; P R ROANE
Journal: Virology Date: 1964-02 Impact factor: 3.616

2. Anatomy of herpes simplex virus DNA. XII. Accumulation of head-to-tail concatemers in nuclei of infected cells and their role in the generation of the four isomeric arrangements of viral DNA.

Authors: R J Jacob; L S Morse; B Roizman
Journal: J Virol Date: 1979-02 Impact factor: 5.103

3. Anatomy of herpes simplex virus DNA. III. Characterization of defective DNA molecules and biological properties of virus populations containing them.

Authors: N Frenkel; R J Jacob; R W Honess; G S Hayward; H Locker; B Roizman
Journal: J Virol Date: 1975-07 Impact factor: 5.103

4. Anatomy of herpes simplex virus DNA VIII. Properties of the replicating DNA.

Authors: R J Jacob; B Roizman
Journal: J Virol Date: 1977-08 Impact factor: 5.103

5. Studies on the intracellular replicating DNA of herpes simplex virus type 1.

Authors: I Hirsch; G Cabral; M Patterson; N Biswal
Journal: Virology Date: 1977-08 Impact factor: 3.616

6. Electron microscopy of herpes simplex virus DNA molecules isolated from infected cells by centrifugation in CsCl density gradients.

Authors: A Friedmann; J Shlomai; Y Becker
Journal: J Gen Virol Date: 1977-03 Impact factor: 3.891

7. Replication of herpesvirus DNA. II. Sedimentation characteristics of newly synthesized DNA.

Authors: T Ben-Porat; S A Tokazewski
Journal: Virology Date: 1977-06-15 Impact factor: 3.616

8. Macromolecular synthesis in cells infected with herpes simplex virus.

Authors: B Roizman; G S Borman; M K Rousta
Journal: Nature Date: 1965-06-26 Impact factor: 49.962

9. An improved technique for obtaining enhanced infectivity with herpes simplex virus type 1 DNA.

Authors: N D Stow; N M Wilkie
Journal: J Gen Virol Date: 1976-12 Impact factor: 3.891

10. Anatomy of herpes simplex virus DNA. VI. Defective DNA originates from the S component.

Authors: N Frenkeĺ; H Locker; W Batterson; G S Hayward; B Roizman
Journal: J Virol Date: 1976-11 Impact factor: 5.103

23 in total

1. A sequence within the varicella-zoster virus (VZV) OriS is a negative regulator of DNA replication and is bound by a protein complex containing the VZV ORF29 protein.

Authors: Mohamed I Khalil; Ann Arvin; Jeremy Jones; William T Ruyechan
Journal: J Virol Date: 2011-09-21 Impact factor: 5.103

6. A 269-amino-acid segment with a pseudo-leucine zipper and a helix-turn-helix motif codes for the sequence-specific DNA-binding domain of herpes simplex virus type 1 origin-binding protein.

Authors: S Deb; S P Deb
Journal: J Virol Date: 1991-06 Impact factor: 5.103

7. Elements in the transcriptional regulatory region flanking herpes simplex virus type 1 oriS stimulate origin function.

Authors: S W Wong; P A Schaffer
Journal: J Virol Date: 1991-05 Impact factor: 5.103

A 67-base-pair segment from the Ori-S region of herpes simplex virus type 1 encodes origin function.

1. THE MULTIPLICATION OF HERPES SIMPLEX VIRUS. II. THE RELATION BETWEEN PROTEIN SYNTHESIS AND THE DUPLICATION OF VIRAL DNA IN INFECTED HEP-2 CELLS.

2. Anatomy of herpes simplex virus DNA. XII. Accumulation of head-to-tail concatemers in nuclei of infected cells and their role in the generation of the four isomeric arrangements of viral DNA.

3. Anatomy of herpes simplex virus DNA. III. Characterization of defective DNA molecules and biological properties of virus populations containing them.

4. Anatomy of herpes simplex virus DNA VIII. Properties of the replicating DNA.

5. Studies on the intracellular replicating DNA of herpes simplex virus type 1.

6. Electron microscopy of herpes simplex virus DNA molecules isolated from infected cells by centrifugation in CsCl density gradients.

7. Replication of herpesvirus DNA. II. Sedimentation characteristics of newly synthesized DNA.

8. Macromolecular synthesis in cells infected with herpes simplex virus.

9. An improved technique for obtaining enhanced infectivity with herpes simplex virus type 1 DNA.

10. Anatomy of herpes simplex virus DNA. VI. Defective DNA originates from the S component.

1. A sequence within the varicella-zoster virus (VZV) OriS is a negative regulator of DNA replication and is bound by a protein complex containing the VZV ORF29 protein.

2. Analysis of the herpes simplex virus type 1 OriS sequence: mapping of functional domains.

3. Analysis of an origin of DNA replication located at the L terminus of the genome of pseudorabies virus.

4. Multicomponent origin of cytomegalovirus lytic-phase DNA replication.

5. Herpes simplex virus origin-binding protein (UL9) loops and distorts the viral replication origin.

6. A 269-amino-acid segment with a pseudo-leucine zipper and a helix-turn-helix motif codes for the sequence-specific DNA-binding domain of herpes simplex virus type 1 origin-binding protein.

7. Elements in the transcriptional regulatory region flanking herpes simplex virus type 1 oriS stimulate origin function.

8. Analysis of Ori-S sequence of HSV-1: identification of one functional DNA binding domain.

9. Cloning and expression of an equine herpesvirus 1 origin-binding protein.

10. Cellular transcription factors Sp1 and Sp3 suppress varicella-zoster virus origin-dependent DNA replication.