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Literature DB >> 185428

Anatomy of herpes simplex virus DNA. VI. Defective DNA originates from the S component.

N Frenkeĺ, H Locker, W Batterson, G S Hayward, B Roizman.

Abstract

We previously reported that serial propagation of the Justin strain of herpes simplex virus 1 [HSV-1 (Justin)] results in the generation of defective DNA molecules consisting of tandem repetitions of sequences of limited complexity. In the present study, HSV-1 DNA was cleaved with the restriction endonucleases BglII and EcoRI. The fragments were electrophoretically separated on agarose gels, transferred to nitrocellulose strips, and then hybridized with 32P-labeled HSV-1 (Justin) defective DNA. The data allow us to conclude that DNA sequences contained in the repeat unit of defective DNA originate from the S segment of the wild-type viral DNA molecule.

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Year: 1976 PMID： 185428 PMCID： PMC355020

Source DB: PubMed Journal: J Virol ISSN： 0022-538X Impact factor: 5.103

18 in total

1. Inverted repetitions in the chromosome of herpes simplex virus.

Authors: P Sheldrick; N Berthelot
Journal: Cold Spring Harb Symp Quant Biol Date: 1975

2. Analysis of DNA of defective herpes simplex virus type 1 by restriction endonuclease cleavage and nucleic acid hybridization.

Authors: M Wagner; J Skare; W C Summers
Journal: Cold Spring Harb Symp Quant Biol Date: 1975

3. Anatomy of herpes simplex virus DNA. V. Terminally repetitive sequences.

Authors: S Wadsworth; G S Hayward; B Roizman
Journal: J Virol Date: 1976-02 Impact factor: 5.103

4. Cyclic appearance of defective interfering particles of herpes simplex virus and the concomitant accumulation of early polypeptide VP175.

Authors: B K Murray; N Biswal; J B Bookout; R E Lanford; R J Courtney; J L Melnick
Journal: Intervirology Date: 1975 Impact factor: 1.763

Review 5. Human herpersviruses I: a model for molecular organization and regulation of herpesviruses-a review.

Authors: B Roizman; G Hayward; R Jacob; S Wadsworth; N Frenkel; R W Honess; M Kozak
Journal: IARC Sci Publ Date: 1975

6. The evolution of new species of viral DNA during serial passage of simian virus 40 at high multiplicity.

Authors: W W Brockman; T N Lee; D Nathans
Journal: Virology Date: 1973-08 Impact factor: 3.616

7. Proteins specified by herpes simplex virus. XI. Identification and relative molar rates of synthesis of structural and nonstructural herpes virus polypeptides in the infected cell.

Authors: R W Honess; B Roizman
Journal: J Virol Date: 1973-12 Impact factor: 5.103

8. Herpes simplex virus DNA.

Authors: Y Becker; H Dym; I Sarov
Journal: Virology Date: 1968-10 Impact factor: 3.616

9. Anatomy of herpes simplex virus DNA: evidence for four populations of molecules that differ in the relative orientations of their long and short components.

Authors: G S Hayward; R J Jacob; S C Wadsworth; B Roizman
Journal: Proc Natl Acad Sci U S A Date: 1975-11 Impact factor: 11.205

10. Size, composition, and structure of the deoxyribonucleic acid of herpes simplex virus subtypes 1 and 2.

Authors: E D Kieff; S L Bachenheimer; B Roizman
Journal: J Virol Date: 1971-08 Impact factor: 5.103

35 in total

Review 1. HSV-1-based vectors for gene therapy of neurological diseases and brain tumors: part II. Vector systems and applications.

Authors: A Jacobs; X O Breakefield; C Fraefel
Journal: Neoplasia Date: 1999-11 Impact factor: 5.715

2. Structure and origin of defective genomes contained in serially passaged herpes simplex virus type 1 (Justin).

Authors: H Locker; N Frenkel
Journal: J Virol Date: 1979-03 Impact factor: 5.103

3. DNA of human cytomegalovirus: size heterogeneity and defectiveness resulting from serial undiluted passage.

Authors: M F Stinski; E S Mocarski; D R Thomsen
Journal: J Virol Date: 1979-07 Impact factor: 5.103

4. Origin of two different classes of defective HSV-1 Angelotti DNA.

Authors: H C Kaerner; I B Maichle; A Ott; C H Schröder
Journal: Nucleic Acids Res Date: 1979-04 Impact factor: 16.971

5. Analysis of the herpes simplex virus type 1 OriS sequence: mapping of functional domains.

Authors: D W Martin; S P Deb; J S Klauer; S Deb
Journal: J Virol Date: 1991-08 Impact factor: 5.103

6. Anatomy of herpes simplex virus DNA VIII. Properties of the replicating DNA.

Authors: R J Jacob; B Roizman
Journal: J Virol Date: 1977-08 Impact factor: 5.103

7. Physical map of the origin of defective DNA in herpes simplex virus type 1 DNA.

Authors: B J Graham; Z Bengali; G F Vande Woude
Journal: J Virol Date: 1978-03 Impact factor: 5.103

8. Anatomy of herpes simplex virus (HSV) DNA. X. Mapping of viral genes by analysis of polypeptides and functions specified by HSV-1 X HSV-2 recombinants.

Authors: L S Morse; L Pereira; B Roizman; P A Schaffer
Journal: J Virol Date: 1978-05 Impact factor: 5.103

9. Anatomy of herpes simplex virus DNA VII. alpha-RNA is homologous to noncontiguous sites in both the L and S components of viral DNA.

Authors: P C Jones; G S Hayward; B Roizman
Journal: J Virol Date: 1977-01 Impact factor: 5.103

10. Structure and genetic complexity of the genomes of herpesvirus defective-interfering particles associated with oncogenic transformation and persistent infection.

Authors: R P Baumann; S A Dauenhauer; G B Caughman; J Staczek; D J O'Callaghan
Journal: J Virol Date: 1984-04 Impact factor: 5.103